Author

G. Bruce Wisely

Observed names: G B Wisely, G Bruce Wisely, G. B. Wisely, G.B Wisely, G.B. Wisely, G.Bruce Wisely, George B. Wisely

Observed institutions: University of North Carolina at Chapel Hill, National Institutes of Health, Howard Hughes Medical Institute, Harvard University, Duke University, GlaxoSmithKline (United Kingdom), National Institute of Environmental Health Sciences, GlaxoSmithKline (United States), Duke Medical Center, UNC Lineberger Comprehensive Cancer Center, University of Pennsylvania, The University of Texas Southwestern Medical Center, University of Lausanne

OpenAlex ID: A5065672731

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 · Steven A. Kliewer, Scott S. Sundseth, et al. · Proceedings of the National Academy of Sciences · 2,186

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 · Robert T. Nolte, G. Bruce Wisely, et al. · Nature · 1,982

Molecular Recognition of Fatty Acids by Peroxisome Proliferator–Activated Receptors

1999 · H.Eric Xu, Millard H Lambert, et al. · Molecular Cell · 1,186

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Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ

1999 · Bethany A. Janowski, Michael J. Grogan, et al. · Proceedings of the National Academy of Sciences · 966

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

2000 · Linda B. Moore, Bryan Goodwin, et al. · Proceedings of the National Academy of Sciences · 952

The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity

2001 · Ryan E. Watkins, G. Bruce Wisely, et al. · Science · 770

Rev-erbα, a Heme Sensor That Coordinates Metabolic and Circadian Pathways

2007 · Lei Yin, Nan Wu, et al. · Science · 729

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 · Stacey A. Jones, Linda B. Moore, et al. · Molecular Endocrinology · 671

NF- k appa B regulates IL-1 beta transcription through a consensus NF- k appa B binding site and a nonconsensus CRE-like site.

1994 · J P Cogswell, M M Godlevski, et al. · The Journal of Immunology · 363

Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators

1998 · Stefan Westin, Riki Kurokawa, et al. · Nature · 338

2.1 Å Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin,

2003 · Ryan E. Watkins, Jodi M. Maglich, et al. · Biochemistry · 322

Hepatocyte Nuclear Factor 4 Is a Transcription Factor that Constitutively Binds Fatty Acids

2002 · G.Bruce Wisely, Ann B. Miller, et al. · Structure · 313

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Structural Disorder in the Complex of Human Pregnane X Receptor and the Macrolide Antibiotic Rifampicin

2005 · Jill E. Chrencik, Jillian Orans, et al. · Molecular Endocrinology · 201

Crystallization of protein–ligand complexes

2006 · Anne M. Hassell, Gang An, et al. · Acta Crystallographica Section D Biological Crystallography · 178

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A New Series of Estrogen Receptor Modulators That Display Selectivity for Estrogen Receptor β

2002 · Brad R. Henke, Thomas G. Consler, et al. · Journal of Medicinal Chemistry · 165

GSK4112, a Small Molecule Chemical Probe for the Cell Biology of the Nuclear Heme Receptor Rev-erbα

2010 · Daniel Grant, Lei Yin, et al. · ACS Chemical Biology · 154

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064

2008 · Adwoa Akwabi-Ameyaw, Jonathan Y. Bass, et al. · Bioorganic & Medicinal Chemistry Letters · 151

Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix

2000 · Robert T. Gampe, Valerie G. Montana, et al. · Genes & Development · 140

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Frequent Imprecise Excision Among Reversions of a P Element-caused Lethal Mutation in Drosophila

1984 · Robert A Voelker, Arno L Greenleaf, et al. · Genetics · 97

A CRE/ATF-Like Site in the Upstream Regulatory Sequence of the Human Interleukin 1β Gene Is Necessary for Induction in U937 and THP-1 Monocytic Cell Lines

1993 · John G. Gray, Gyan Chandra, et al. · Molecular and Cellular Biology · 87

Nucleotide sequence of the BALB/c mouse β-globin complex

1989 · W.R Shehee, D.D Loeb, et al. · Journal of Molecular Biology · 85

Human Recombinant Phosphodiesterase 4B2B Binds (R)-Rolipram at a Single Site with Two Affinities

1997 · Warren J. Rocque, Gaochao Tian, et al. · Biochemistry · 66

FXR agonist activity of conformationally constrained analogs of GW 4064

2009 · Adwoa Akwabi-Ameyaw, Jonathan Y. Bass, et al. · Bioorganic & Medicinal Chemistry Letters · 63

Human PXR Forms a Tryptophan Zipper-Mediated Homodimer

2006 · Schroeder M. Noble, Virginia E. Carnahan, et al. · Biochemistry · 63

Production of monoclonal antibodies using recombinant baculovirus displaying gp64–fusion proteins

2000 · Kathryn M Lindley, Jui-Lan Su, et al. · Journal of Immunological Methods · 62

Works count: 43

Citation count: 12,620

H-index: 29

I10-index: 34