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Author

Zuberwasim Sayyad

Institution: Cleveland Clinic
ORCID: 0000-0003-1799-7604
Observed ORCID: 0000-0003-1799-7604
OpenAlex ID: A5065738905
661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively
2017 · Zuberwasim Sayyad, Kapil Sirohi, et al. · Scientific Reports · 101
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Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin
2018 · Ghanshyam Swarup, Zuberwasim Sayyad · Frontiers in Immunology · 74
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A glaucoma‐ and ALS‐associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress
2021 · Swetha Medchalmi, Priyanka Tare, et al. · FEBS Journal · 43
Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication
2023 · Taryn Serman, Cindy Chiang, et al. · Cell Host & Microbe · 37
Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer
2023 · Mohammad Afsar, GuanQun Liu, et al. · Nature Communications · 35
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ISGylation of the SARS-CoV-2 N protein by HERC5 impedes N oligomerization and thereby viral RNA synthesis
2024 · Junji Zhu, GuanQun Liu, et al. · Journal of Virology · 34
TRIM23 mediates cGAS-induced autophagy in anti-HSV defense
2025 · Dhiraj Acharya, Zuberwasim Sayyad, et al. · Nature Communications · 22
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MDA5 ISGylation is crucial for immune signaling to control viral replication and pathogenesis
2025 · Lucky Sarkar, GuanQun Liu, et al. · Proceedings of the National Academy of Sciences · 22
A glaucoma‐associated OPTN polymorphism, M98K sensitizes retinal cells to endoplasmic reticulum stress and tumour necrosis factor α
2023 · Zuberwasim Sayyad, Sreeram Kaveti, et al. · FEBS Journal · 21
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Human primary retinal cells as an in-vitro model for investigating defective signalling caused by OPTN mutants associated with glaucoma
2021 · Zuberwasim Sayyad, Sushma Vishwakarma, et al. · Neurochemistry International · 12
TRIM Proteins: Key Regulators of Immunity to Herpesvirus Infection
2024 · Zuberwasim Sayyad, Dhiraj Acharya, et al. · Viruses · 8
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Molecular aspects of cytoprotection by Optineurin during stress and disease
2025 · Ghanshyam Swarup, Swetha Medchalmi, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 6
Independent amino acid residues in the S2 pocket of falcipain-3 determine its specificity for P2 residues in substrates
2015 · Venkata Karunakar Kolla, Rajesh Prasad, et al. · Molecular and Biochemical Parasitology · 5
Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism
2026 · Junji Zhu, GuanQun Liu, et al. · Immunity · 3
Glaucoma-associated polymorphism M98K-OPTN sensitizes retinal cells to protein homeostasis stress through p62-mediated caspase activation
2025 · Swetha Medchalmi, Zuberwasim Sayyad, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 1
Publisher Correction: TRIM23 mediates cGAS-induced autophagy in anti-HSV defense
2025 · Dhiraj Acharya, Zuberwasim Sayyad, et al. · Nature Communications · 1
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Reversible ISG15 conjugation regulates antiviral innate immunity and intracellular metabolism 2305671
2026 · Junji Zhu, GuanQun Liu, et al. · The Journal of Immunology
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Author response for "A glaucoma‐associated OPTN polymorphism, M98K sensitizes retinal cells to endoplasmic reticulum stress and tumor necrosis factor α"
2022 · Zuberwasim Sayyad, Sreeram Kaveti, et al. · Publons reviews and discussion
Human primary retinal cells as an in-vitro cell culture model for investigating defective signalling caused by OPTN mutants associated with glaucoma
2019 · Zuberwasim Sayyad, Sushma Vishwakarma, et al. · Investigative Ophthalmology & Visual Science
Works count: 19
Citation count: 425
H-index: 10
I10-index: 10
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