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Gabriela Denning

Cloning of a Novel Phosphatidylinositol Kinase-related Kinase
2001 · Gabriela Denning, Lee Jamieson, et al. · Journal of Biological Chemistry · 161
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Directed Engineering of a High-expression Chimeric Transgene as a Strategy for Gene Therapy of Hemophilia A
2009 · Christopher B Doering, Gabriela Denning, et al. · Molecular Therapy · 79
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Lentiviral Vector Platform for Production of Bioengineered Recombinant Coagulation Factor VIII
2010 · H Trent Spencer, Gabriela Denning, et al. · Molecular Therapy · 59
Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A
2024 · Alok Srivastava, Aby Abraham, et al. · New England Journal of Medicine · 58
Preclinical Development of a Hematopoietic Stem and Progenitor Cell Bioengineered Factor VIII Lentiviral Vector Gene Therapy for Hemophilia A
2018 · Christopher B. Doering, Gabriela Denning, et al. · Human Gene Therapy · 56
Comparison of Factor VIII Transgenes Bioengineered for Improved Expression in Gene Therapy of Hemophilia A
2009 · Kerry L. Dooriss, Gabriela Denning, et al. · Human Gene Therapy · 47
The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain
2019 · Ian W. Smith, Anne E. d'Aquino, et al. · Journal of Thrombosis and Haemostasis · 37
Generation of an optimized lentiviral vector encoding a high-expression factor VIII transgene for gene therapy of hemophilia A
2012 · J M Johnston, G Denning, et al. · Gene Therapy · 34
Microfluidic Transduction Harnesses Mass Transport Principles to Enhance Gene Transfer Efficiency
2017 · Reginald Tran, David R. Myers, et al. · Molecular Therapy · 33
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F5‐Atlanta: A novel mutation in F5 associated with enhanced East Texas splicing and FV‐short production
2021 · Karen L. Zimowski, Teodolinda Petrillo, et al. · Journal of Thrombosis and Haemostasis · 27
High-throughput screening identifies compounds that enhance lentiviral transduction
2014 · J M Johnston, G Denning, et al. · Gene Therapy · 19
P1 and NR1 Plasmid Replication during the Cell Cycle of Escherichia coli
2001 · Joseph A. Bogan, Julia E. Grimwade, et al. · Plasmid · 17
Non-genotoxic conditioning facilitates hematopoietic stem cell gene therapy for hemophilia A using bioengineered factor VIII
2021 · Athena L. Russell, Chengyu Prince, et al. · Molecular Therapy — Methods & Clinical Development · 15
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Pharmacokinetic analysis identifies a factor VIII immunogenicity threshold after AAV gene therapy in hemophilia A mice
2022 · Taran S. Lundgren, Gabriela Denning, et al. · Blood Advances · 11
Identification of coagulation factor IX variants with enhanced activity through ancestral sequence reconstruction
2021 · Kristopher A. Knight, Christopher W. Coyle, et al. · Blood Advances · 10
Factor V Atlanta: A Novel Mutation in the F5 Gene Reveals Potential New Cis-Acting Elements Involved in Regulating FV-Short and TFPI Levels
2017 · Karen L. Zimowski, Michelle Ho, et al. · Blood · 5
Humanization and functional characterization of enhanced coagulation factor IX variants identified through ancestral sequence reconstruction
2023 · Christopher W. Coyle, Kristopher A. Knight, et al. · Journal of Thrombosis and Haemostasis · 3
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Assessment of Transduction of CD34+ Human Hematopoietic Stem Cells from Patients with Severe Hemophilia-Α with Lentiviral Vector Carrying a High Expression FVIII Transgene (CD68-ET3-LV)
2023 · Gurbind Singh, Mohanashankar A M, et al. · Blood · 3
Development of a Novel Recombinant Factor VIII Product through Transgene Engineering and Lentiviral-Driven Expression
2008 · Keith W Kerstann, Pete Lollar, et al. · Blood · 2
Factor VIII Expression from a Novel F8 Transgene through a Lentiviral Vector Transduced CD34+ Autologous Hematopoietic Stem Cells for Gene Therapy of Severe Hemophilia Α: Final Results from a Phase 1 Clinical Trial
2024 · Alok Srivastava, Aby Abraham, et al. · Blood · 1
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The Chemistry Manufacturing and Controls (CMC) section of gene therapy-based INDs: overview in a changing landscape
2021 · Gabriela Denning · Cell and Gene Therapy Insights
Preclinical Development and Validation of a Hematopoietic Stem Cell-Based Lentivector Treatment for Hemophilia a
2015 · Christopher B Doering, Gabriela Denning, et al. · Blood
Humanized High-Expression Factor VIII Encoding Lentiviral Vectors Efficiently Drive High-Level FVIII Expression in Murine and Human Hematopoietic Cells
2008 · Christopher Doering, Gabriela Denning, et al. · Blood
Works count: 23
Citation count: 677
H-index: 13
I10-index: 15
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