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Philipp Ochtrop

Observed names: Ochtrop, Philipp, P. Ochtrop
ORCID: 0000-0003-4498-3136
Observed ORCID: 0000-0003-4498-3136
OpenAlex ID: A5066069685
Recent advances of thiol-selective bioconjugation reactions
2020 · Philipp Ochtrop, Christian Peter Richard Hackenberger · Current Opinion in Chemical Biology · 195
Ethynylphosphonamidates for the Rapid and Cysteine‐Selective Generation of Efficacious Antibody–Drug Conjugates
2019 · Marc‐André Kasper, Andreas Stengl, et al. · Angewandte Chemie International Edition · 71
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Covalent Protein Labeling by Enzymatic Phosphocholination
2015 · Katharina Heller, Philipp Ochtrop, et al. · Angewandte Chemie International Edition · 46
Front Cover: N‐Hydroxysuccinimide‐Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates (ChemBioChem 1‐2/2020)
2019 · Marc‐André Kasper, Marcus Gerlach, et al. · ChemBioChem · 44
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Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent in vivo PK profile
2023 · Philipp Ochtrop, Jahaziel Jahzerah, et al. · Chemical Science · 37
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DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling
2022 · Christian E. Stieger, Yerin Park, et al. · Angewandte Chemie International Edition · 33
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Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody–Drug Conjugates
2023 · Saskia Schmitt, Paul Machui, et al. · Molecular Cancer Therapeutics · 25
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Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination
2020 · Stefan Ernst, Felix Ecker, et al. · Science Advances · 18
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N‐Hydroxysuccinimide‐Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates
2019 · Marc‐André Kasper, Marcus Gerlach, et al. · ChemBioChem · 16
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Site‐Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy
2020 · Jonathan Schwach, Ksenia Kolobynina, et al. · ChemBioChem · 15
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Ethynylphosphonamidates for the Rapid and Cysteine‐Selective Generation of Efficacious Antibody–Drug Conjugates
2019 · Marc‐André Kasper, Andreas Stengl, et al. · Angewandte Chemie · 11
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Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates
2025 · Marina Able, Marc-André Kasper, et al. · Leukemia · 10
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Expanding the payload scope in antibody-drug conjugates by delivery of hydroxy-containing drugs through self-immolative phosphoramidates
2026 · Philipp Ochtrop, Anil P. Jagtap, et al. · Nature Communications · 9
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Exploring the Substrate Scope of the Bacterial Phosphocholine Transferase AnkX for Versatile Protein Functionalization
2019 · Philipp Ochtrop, Stefan Ernst, et al. · ChemBioChem · 9
An amphipathic cyclic tetrapeptide scaffold containing halogenated β2,2‐amino acids with activity against multiresistant bacteria
2018 · Marianne H. Paulsen, Eskil André Karlsen, et al. · Journal of Peptide Science · 8
TUB-040, a Homogeneous and Hydrophilic NaPi2b-Targeting ADC with Stably Linked Exatecan, Exhibits Long-lasting Antitumor Activity and a Well-Tolerated Safety Profile
2025 · Annette M. Vogl, Saskia Schmitt, et al. · Molecular Cancer Therapeutics · 7
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Abstract 2622: TUB-040, a novel Napi2b-targeting ADC built with ethynylphosphonamidate conjugation chemistry, demonstrates high and long-lasting anti-tumor efficacy via Topoisomerase-I inhibition and excellent tolerability predictive of a wide therapeutic window in humans
2024 · Saskia Schmitt, Isabelle Mai, et al. · Cancer Research · 7
Kovalente Proteinmarkierung durch enzymatische Phosphocholinierung
2015 · Katharina Heller, Philipp Ochtrop, et al. · Angewandte Chemie · 7
Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b
2023 · Marietta S. Kaspers, Vivian Pogenberg, et al. · Nature Communications · 5
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Abstract 2623: Enabling 5T4 for targeted cancer therapy: TUB-030, a novel ADC built with ethynylphosphonamidate conjugation chemistry, shows long-lasting anti-tumor activity via Topoisomerase-I inhibition with an optimized therapeutic index
2024 · Saskia Schmitt, Isabelle Mai, et al. · Cancer Research · 3
Modular solid-phase synthesis of electrophilic cysteine-selective ethynyl-phosphonamidate peptides
2022 · Sarah Hansen, Jan Vincent V. Arafiles, et al. · Chemical Communications · 3
Selective protein functionalisation via enzymatic phosphocholination
2017 · Philipp Ochtrop · KTH Publication Database DiVA (KTH Royal Institute of Technology) · 1
The Legionella phosphocholinase AnkX modulates IMPDH2 regulation and cytoophidia dynamics
2026 · Pia Stauffer, Marietta S. Kaspers, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Supplementary Table 1 from TUB-040, a Homogeneous and Hydrophilic NaPi2b-Targeting ADC with Stably Linked Exatecan, Exhibits Long-lasting Antitumor Activity and a Well-Tolerated Safety Profile
2025 · Annette M. Vogl, Saskia Schmitt, et al.
Supplementary Table 2 from TUB-040, a Homogeneous and Hydrophilic NaPi2b-Targeting ADC with Stably Linked Exatecan, Exhibits Long-lasting Antitumor Activity and a Well-Tolerated Safety Profile
2025 · Annette M. Vogl, Saskia Schmitt, et al.
Works count: 61
Citation count: 580
H-index: 11
I10-index: 12
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