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Kenji Akahane

Observed names: K Akahane, K. AKAHANE, K. Akahane, KENJI AKAHANE, Kenji AKAHANE
ORCID: 0000-0003-0778-6782
Observed ORCID: 0000-0003-0778-6782
OpenAlex ID: A5068515999
Highly selective inhibitors of thromboxane synthetase. 1. Imidazole derivatives
1981 · Kinji Iizuka, Kenji Akahane, et al. · Journal of Medicinal Chemistry · 156
Three-dimensional structure of human renin.
1985 · K Akahane, H Umeyama, et al. · Hypertension · 96
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Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction
1990 · Kinji Iizuka, Tetsuhide Kamijo, et al. · Journal of Medicinal Chemistry · 94
New human renin inhibitors containing an unnatural amino acid, norstatine
1988 · Kinji Iizuka, Tetsuhide Kamijo, et al. · Journal of Medicinal Chemistry · 64
Design and synthesis of an orally potent human renin inhibitor containing a novel amino acid, cyclohexylnorstatine
1989 · Kinji Iizuka, Tetsuhide Kamijo, et al. · Journal of the Chemical Society Chemical Communications · 46
Synthesis and structure-activity relationships of human renin inhibitors designed from angiotensinogen transition state.
1990 · Kinji IIZUKA, Tetsuhide KAMIJO, et al. · Chemical and Pharmaceutical Bulletin · 12
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Binding Specificity of Papain and Cathepsin B
2017 · Kenji Akahane, Hideaki Umeyama · Enzyme · 11
Hydrophobic effect on the protein-ligand interaction; Hydrophobic field-effect index and hydrophobic correlation index.
1989 · Kenji AKAHANE, Yasuo NAGANO, et al. · Chemical and Pharmaceutical Bulletin · 9
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A comparison between the combined effect of calcium carbonate with sucroferric oxyhydroxide and other phosphate binders: an in vitro and in vivo experimental study
2019 · Atsushi Yaguchi, Kenji Akahane, et al. · BMC Nephrology · 8
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Synthesis of human renin inhibitory peptides, angiotensinogen transition-state analogs containing a Retro-inverso amide bond.
1990 · Hiromu HARADA, Kinji IIZUKA, et al. · Chemical and Pharmaceutical Bulletin · 6
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Structure-activity relationship of fluorine-containing renin inhibitory peptides based upon the tertiary structure of human renin.
1988 · KENJI AKAHANE, TETSUHIDE KAMIJO, et al. · Chemical and Pharmaceutical Bulletin · 6
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Efficacy of Mitiglinide Combined with Dapagliflozin in Streptozotocin-nicotinamide-induced Type 2 Diabetic Rats and in Zucker Fatty Rats
2014 · K. Akahane, T. Inoue, et al. · Drug Research · 5
Determination of d- and l-enantiomers of methionine and [2H3]methionine in plasma by gas chromatography–mass spectrometry
2005 · Hiroshi Hasegawa, Yoshihiko Shinohara, et al. · Journal of Chromatography B · 5
New human renin inhibitory peptides. Angiotensinogen transition-state analogues containing novel Leu-Val replacement and a retro-inverso amide bond.
1988 · Kinji Iizuka, Tetsuhide Kamijo, et al. · Chemical and Pharmaceutical Bulletin · 5
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Energy decomposition analysis of borane monoammoniate: origin of the rotational barrier to nonrigid rotation
1985 · K. Akahane, S. Nakagawa, et al. · Journal of Molecular Structure · 4
Effects of combination of mitiglinide with various oral antidiabetic drugs in streptozotocin‐nicotinamide‐induced type 2 diabetic rats and Zucker fatty rats
2017 · Kenji Akahane, Kazuma Ojima, et al. · Clinical and Experimental Pharmacology and Physiology · 2
Comparison of the Effects of Mitiglinide and Glibenclamide Administered in Combination with the Dipeptidyl Peptidase-IV Inhibitor Sitagliptin in Rats with Streptozotocin-Nicotinamide-Induced Type 2 Diabetes
2017 · Kenji Akahane, Kazuma Ojima, et al. · Drug Research · 2
Studies on the Synthesis of Cholecystokinin A Receptor Antagonists. IV. Synthesis and Cholecystokinin A Receptor Inhibitory Activities of Benzimidazole Derivatives
1996 · Yukiyoshi AJISAWA, Kenji AKAHANE, et al. · YAKUGAKU ZASSHI · 1
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Conformational study of a potent human renin inhibitor: X-ray crystal structure of isopropyl (2R,3S)-4-cyclohexyl-2-hydroxy-3-{N-[(2R)-2-morpholinocarbonylmethyl-3-(1-naphthyl)propionyl]-L-histidylamino}butyrate (KRI-1314), a pentapeptide analogue with amino acid sequence corresponding to the cleavage site of angiotensinogen
1991 · Mitsunobu Doi, Yasuko In, et al. · Journal of the Chemical Society Perkin Transactions 1 · 1
A new method for calculating hydrophobic interaction energy in the biological system.
1986 · Kenji Akahane, Hideaki Umeyama · Chemical and Pharmaceutical Bulletin · 1
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ChemInform Abstract: Studies on the Synthesis of Cholecystokinin A Receptor Antagonists. Part 4. Synthesis and Cholecystokinin A Receptor Inhibitory Activities of Benzimidazole Derivatives
1997 · Y. AJISAWA, K. AKAHANE, et al. · ChemInform
Drug design based on receptor modeling using a system “BIOCES [E]”
1995 · Kenji Akahane, Hideaki Umeyama · Pharmacochemistry library
ChemInform Abstract: Design and Synthesis of an Orally Potent Human Renin Inhibitor (R,S,S,R)‐(I) Containing a Novel Amino Acid, Cyclohexylnorstatine (2R,3S)‐(II).
1990 · K. IIZUKA, T. KAMIJO, et al. · ChemInform
Renin inhibitors designed on the basis of angiotensinogen transition state
1989 · Kinji Iizuka, Tetsuhide Kamijo, et al. · Journal of Pharmacobio-Dynamics
Three-dimensional Structure of Human Renin and Renin Inhibitors. New Approach to Drug Design
1985 · Kenji Akahane, Setsuko Nakagawa, et al. · Journal of Pharmacobio-Dynamics
Works count: 26
Citation count: 534
H-index: 8
I10-index: 7
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