Get started
Author

Edward J. Hennessy

Observed names: E. Hennessy, E.J. Hennessy, Edward Hennessy, Edward J Hennessy, Hennessy, E.J.
ORCID: 0000-0002-3431-4396
Observed ORCID: 0000-0002-3431-4396
OpenAlex ID: A5068941202
Synthesis of Substituted Oxindoles from α-Chloroacetanilides via Palladium-Catalyzed C−H Functionalization
2003 · Edward J. Hennessy, Stephen L. Buchwald · Journal of the American Chemical Society · 383
A General and Mild Copper-Catalyzed Arylation of Diethyl Malonate
2002 · Edward J. Hennessy, Stephen L. Buchwald · Organic Letters · 191
Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)
2013 · Edward J. Hennessy, Ammar Adam, et al. · Journal of Medicinal Chemistry · 118
Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy
2021 · Claire M. Patterson, Srividya B. Balachander, et al. · Communications Biology · 96
PDF
AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia
2020 · Srividya B. Balachander, Steven W. Criscione, et al. · Clinical Cancer Research · 73
Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors
2019 · Gavin W. Collie, Cheryl M. Koh, et al. · ACS Medicinal Chemistry Letters · 61
Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs
2008 · Huan Wang, Martin L. Duennwald, et al. · Proceedings of the National Academy of Sciences · 53
trans-Cyclopropyl β-Amino Acid Derivatives via Asymmetric Cyclopropanation Using a (Salen)Ru(II) Catalyst
2003 · Jason A. Miller, Edward J. Hennessy, et al. · The Journal of Organic Chemistry · 52
Discovery of Potent KIFC1 Inhibitors Using a Method of Integrated High-Throughput Synthesis and Screening
2014 · Bin Yang, Michelle L. Lamb, et al. · Journal of Medicinal Chemistry · 42
Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy
2021 · William McCoull, Scott Boyd, et al. · Journal of Medicinal Chemistry · 41
Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity
2016 · Edward J. Hennessy · Bioorganic & Medicinal Chemistry Letters · 40
Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors
2016 · William McCoull, Edward J. Hennessy, et al. · ACS Medicinal Chemistry Letters · 34
Generating Selective Leads for Mer Kinase Inhibitors—Example of a Comprehensive Lead-Generation Strategy
2021 · J. Willem M. Nissink, Sana Bazzaz, et al. · Journal of Medicinal Chemistry · 30
Discovery and Optimization of a Novel Series of Potent Mutant B-Raf V600E Selective Kinase Inhibitors
2013 · Melissa M. Vasbinder, Brian Aquila, et al. · Journal of Medicinal Chemistry · 30
Synthesis of 4,5-Dianilinophthalimide and Related Analogues for Potential Treatment of Alzheimer's Disease via Palladium-Catalyzed Amination
2005 · Edward J. Hennessy, Stephen L. Buchwald · The Journal of Organic Chemistry · 30
Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor
2023 · Iacovos N. Michaelides, Gavin W. Collie, et al. · Journal of Medicinal Chemistry · 26
PDF
Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity
2015 · Edward J. Hennessy, Vibha Oza, et al. · Journal of Medicinal Chemistry · 25
Discovery of aminopiperidine-based Smac mimetics as IAP antagonists
2011 · Edward J. Hennessy, Jamal C. Saeh, et al. · Bioorganic & Medicinal Chemistry Letters · 20
Small molecule inhibitor of apoptosis proteins antagonists: a patent review
2015 · Alexander W Hird, Brian M Aquila, et al. · Expert Opinion on Therapeutic Patents · 19
Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity
2014 · William McCoull, Edward J. Hennessy, et al. · MedChemComm · 18
Preparation of highly functionalized 1,5-disubstituted tetrazoles via palladium-catalyzed Suzuki coupling
2017 · Edward J. Hennessy, Mark Cornebise, et al. · Tetrahedron Letters · 15
Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation
2016 · Edward J. Hennessy, Claudio Chuaqui, et al. · ACS Medicinal Chemistry Letters · 11
Abstract 311: AZD4320 is a potent, dual Bcl-2/xLinhibitor that rapidly induces apoptosis in preclinical hematologic tumor models
2018 · Justin Cidado, J Paul Secrist, et al. · Cancer Research · 5
Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors
2014 · Alexander W. Hird, Brian M. Aquila, et al. · Bioorganic & Medicinal Chemistry Letters · 4
Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists
2015 · Edward J. Hennessy, Gurmit Grewal, et al. · Bioorganic & Medicinal Chemistry Letters · 3
Works count: 62
Citation count: 1,421
H-index: 19
I10-index: 22
Year
Topic
Type