Get started
Author

David P. Humphreys

Observed names: D P Humphreys, D. P. Humphreys, D.P. Humphreys, David Humphreys, David P Humphreys, David Paul Humphreys
OpenAlex ID: A5070702643
The phage abortive infection system, ToxIN, functions as a protein–RNA toxin–antitoxin pair
2009 · Peter C. Fineran, Tim R. Blower, et al. · Proceedings of the National Academy of Sciences · 574
PDF
A processed noncoding RNA regulates an altruistic bacterial antiviral system
2011 · Tim R Blower, Xue Y Pei, et al. · Nature Structural & Molecular Biology · 140
Mutagenesis and Functional Characterization of the RNA and Protein Components of the toxIN Abortive Infection and Toxin-Antitoxin Locus of Erwinia
2009 · T. R. Blower, P. C. Fineran, et al. · Journal of Bacteriology · 85
Microbial protein cell factories fight back?
2021 · Lukas A. Rettenbacher, Klaudia Arauzo-Aguilera, et al. · Trends in biotechnology · 73
PDF
Dissecting the mechanism of action of intravenous immunoglobulin in human autoimmune disease: Lessons from therapeutic modalities targeting Fcγ receptors
2020 · Anthony Shock, David Humphreys, et al. · Journal of Allergy and Clinical Immunology · 73
High-Level Periplasmic Expression in Escherichia coli Using a Eukaryotic Signal Peptide: Importance of Codon Usage at the 5′ End of the Coding Sequence
2000 · David P. Humphreys, Mukesh Sehdev, et al. · Protein Expression and Purification · 69
Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life
2016 · Ralph Adams, Laura Griffin, et al. · mAbs · 68
Human Protein Disulfide Isomerase Functionally Complements a dsbA Mutation and Enhances the Yield of Pectate Lyase C in Escherichia coli
1995 · David P. Humphreys, Neil Weir, et al. · Journal of Biological Chemistry · 60
PDF
A plasmid system for optimization of Fab′ production in Escherichia coli: importance of balance of heavy chain and light chain synthesis
2002 · David P Humphreys, Bruce Carrington, et al. · Protein Expression and Purification · 54
Multivalent Fcγ-receptor engagement by a hexameric Fc-fusion protein triggers Fcγ-receptor internalisation and modulation of Fcγ-receptor functions
2017 · O. S. Qureshi, T. F. Rowley, et al. · Scientific Reports · 53
PDF
Co‐expression of human protein disulphide isomerase (PDI) can increase the yield of an antibody Fab′ fragment expressed in Escherichia coli
1996 · David P. Humphreys, Neil Weir, et al. · FEBS Letters · 53
PDF
A Mixture of Functionally Oligoclonal Humanized Monoclonal Antibodies That Neutralize Clostridium difficile TcdA and TcdB with High Levels ofIn VitroPotency ShowsIn VivoProtection in a Hamster Infection Model
2013 · Nicola L. Davies, Joanne E. Compson, et al. · Clinical and Vaccine Immunology · 52
Therapeutic antibody production technologies: molecules, applications, expression and purification.
2001 · D P Humphreys, D J Glover · PubMed · 51
Mutations in dsbA and dsbB, but not dsbC, lead to an enhanced sensitivity of Escherichia coli to Hg2+ and Cd2+
1999 · Simon J Stafford, David P Humphreys, et al. · FEMS Microbiology Letters · 49
Alternative antibody Fab′ fragment PEGylation strategies: combination of strong reducing agents, disruption of the interchain disulphide bond and disulphide engineering
2007 · David P. Humphreys, Sam P. Heywood, et al. · Protein Engineering Design and Selection · 47
A Robust Fractionation Method for Protein Subcellular Localization Studies in Escherichia Coli
2019 · Gilles Malherbe, David Paul Humphreys, et al. · BioTechniques · 42
PDF
Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding
2016 · Emma Davé, Ralph Adams, et al. · mAbs · 42
Towards a universal disulphide stabilised single chain Fv format: importance of interchain disulphide bond location and vL-vH orientation
2012 · E. E. Weatherill, K. L. Cain, et al. · Protein Engineering Design and Selection · 42
Impact of antibody Fc engineering on translational pharmacology, and safety: insights from industry case studies
2025 · Frank R. Brennan, J. Ryan Polli, et al. · mAbs · 39
PDF
Development of a high yielding E. coli periplasmic expression system for the production of humanized Fab' fragments
2016 · Mark Ellis, Pareshkumar Patel, et al. · Biotechnology Progress · 34
Production of antibodies and antibody fragments in Escherichia coli and a comparison of their functions, uses and modification.
2003 · David P Humphreys · PubMed · 34
F(ab′)2 molecules made from Escherichia coli produced Fab′ with hinge sequences conferring increased serum survival in an animal model
1998 · David P. Humphreys, Olivia M. Vetterlein, et al. · Journal of Immunological Methods · 34
Engineering an Improved IgG4 Molecule with Reduced Disulfide Bond Heterogeneity and Increased Fab Domain Thermal Stability
2012 · Shirley J. Peters, C. Mark Smales, et al. · Journal of Biological Chemistry · 32
Antibodies for Treatment of Clostridium difficile Infection
2014 · David P. Humphreys, Mark H. Wilcox · Clinical and Vaccine Immunology · 31
On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation
2021 · Joshua M. Sopp, Shirley J. Peters, et al. · Communications Biology · 29
PDF
Works count: 53
Citation count: 2,206
H-index: 27
I10-index: 40
Year
Topic
Type