Author

Iuliana Botez

Observed names: Botez, Iuliana, I Botez, I. Botez, Iuliana Botez Pop, Iuliana Botez-Pop

Observed institutions: Centre National de la Recherche Scientifique, École Polytechnique, University of Liège, Servier (France), Laboratoire de Synthèse Organique, Institut de Recherches Internationales Servier (France)

ORCID: 0000-0002-3243-6322

Observed ORCID: 0000-0002-3243-6322

OpenAlex ID: A5070944439

Targeting galectin-3 in inflammatory and fibrotic diseases

2023 · Selena Bouffette, Iuliana Botez, et al. · Trends in Pharmacological Sciences · 170

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Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis

2021 · Franck Brebion, Romain Gosmini, et al. · Journal of Medicinal Chemistry · 64

Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide Scaffold

2013 · Ann-Beth Nørholm, Pierre Francotte, et al. · Journal of Medicinal Chemistry · 42

Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5

2021 · P. Clement-Lacroix, C.B. Little, et al. · Osteoarthritis and Cartilage · 29

Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2 H -1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxides

2014 · Pierre Francotte, Ann-Beth Nørholm, et al. · Journal of Medicinal Chemistry · 27

Ring-Fused Thiadiazines as Core Structures for the Development of Potent AMPA Receptor Potentiators

2010 · B. Pirotte, P. Francotte, et al. · Current Medicinal Chemistry · 23

Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors

2021 · Koffi Sénam Etsè, Jerzy Dorosz, et al. · ACS Chemical Neuroscience · 20

Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces

2014 · Ann-Beth Nørholm, Pierre Francotte, et al. · Journal of Chemical Information and Modeling · 18

GLPG1972: a potent, selective, orally available adamts-5 inhibitor for the treatment of OA

2017 · P. Clement-Lacroix, C. Little, et al. · Osteoarthritis and Cartilage · 16

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A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process

2012 · Laurent Petit, Iuliana Botez, et al. · Tetrahedron Letters · 16

New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring

2023 · Eric Goffin, Pierre Fraikin, et al. · European Journal of Medicinal Chemistry · 15

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New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors

2011 · Gaëlle Dintilhac, Deniz Arslan, et al. · MedChemComm · 12

Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators

2023 · Pierre Francotte, Yasmin Bay, et al. · European Journal of Medicinal Chemistry · 9

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Access to Galectin-3 Inhibitors from Chemoenzymatic Synthons

2020 · Christophe Dussouy, Stéphane Téletchéa, et al. · The Journal of Organic Chemistry · 9

ADAMTS-5 inhibition with the potent and highly selective inhibitor GLPG1972 results in strong disease-modifying OA drug effects in the rat meniscectomy model

2018 · P. Clement-Lacroix, S. Meurisse, et al. · Osteoarthritis and Cartilage · 6

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Structural Exploration around 4-Cyclopropyl-Substituted 1,2,4-Benzothiadiazine 1,1-Dioxides: Impact of the Dihalo-Substitution of the Benzene Ring on α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Receptor Potentiation

2025 · Cindy Lesenfants, Thomas Colson, et al. · Journal of Medicinal Chemistry · 5

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Design, Synthesis and Biological Evaluation of Conformationnally-Restricted Analogues of E7010 as Inhibitors of Tubulin Assembly (ITA) and Vascular Disrupting Agents (VDA)

2022 · Vassili Prudhomme, Mélissa Cucca, et al. · SSRN Electronic Journal · 5

OP0258 Efficacy of the highly selective adamts-5 inhibitor glpg1972 in the rat meniscectomy model

2018 · L. Lepescheux, P. Clement-Lacroix, et al. · Annals of the Rheumatic Diseases · 3

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OP0180 Pharmacological characterization of the ADAMTS-5 inhibitor GLPG1972: an oral anti-catabolic agent for the treatment of osteoarthritis

2017 · P Clement-Lacroix, C Little, et al. · Annals of the Rheumatic Diseases · 2

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New Insights In The Development of Positive Allosteric Modulators of A-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid (AMPA) Receptors Belonging To 3,4-Dihydro-2H-1,2,4-Benzothiadiazine 1,1-Dioxides: Introduction of (Mono/Difluoro)Methyl Groups At The 2-Position of the Thiadiazine Ring

2023 · Eric Goffin, Pierre Fraikin, et al. · SSRN Electronic Journal

Pharmacological profile of S 76892, a new ligand at nicotinic α7-subtype receptors

2015 · L. Danober, C. Louis, et al. · Biochemical Pharmacology

ChemInform Abstract: A Flexible Radical Approach to 5‐Substituted 4,5‐Dihydro‐3H‐pyrido[4,3‐b]azepin‐2‐ones. Some Mechanistic Observations on the Radical Cyclization—Aromatization Process.

2012 · Laurent Petit, Iuliana Botez, et al. · ChemInform

Design, Synthesis and Biological Evaluation of 4-Cycloalkyl-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides Acting as AMPA Potentiators

2012 · Pierre Francotte, Eric Goffin, et al. · ORBi (University of Liège)

Preparation of cyclopropyl thiochroman derivatives and their use as AMPA receptor modulators

2011 · Pierre Francotte, Pascal De Tullio, et al. · ORBi (University of Liège)

Development of cognitive enhancers acting through AMPA potentiation: design of novel thienothiadiazine 1,1-dioxides

2010 · Francotte, Pierre, Goffin, Eric, et al. · ORBi (University of Liège)

Works count: 27

Citation count: 491

H-index: 12

I10-index: 12