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Matthias Frech

Crystal Structure of the Extracellular Segment of Integrin αVβ3 in Complex with an Arg-Gly-Asp Ligand
2002 · Jian-Ping Xiong, Thilo Stehle, et al. · Science · 1,650
Role of Translocation in the Activation and Function of Protein Kinase B
1997 · Mirjana Andjelkovic, Dario R. Alessi, et al. · Journal of Biological Chemistry · 1,058
High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity
1997 · Matthias Frech, Mirjana Andjelkovic, et al. · Journal of Biological Chemistry · 446
Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules
1990 · Ute Krengel, Ilme Schlichting, et al. · Cell · 387
Protein conformational flexibility modulates kinetics and thermodynamics of drug binding
2017 · M. Amaral, D. B. Kokh, et al. · Nature Communications · 294
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Mutational and Kinetic Analyses of the GTPase-Activating Protein (GAP)-p21 Interaction: The C-Terminal Domain of GAP Is Not Sufficient for Full Activity
1992 · P Gideon, J John, et al. · Molecular and Cellular Biology · 291
Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations
2018 · Daria B. Kokh, Marta Amaral, et al. · Journal of Chemical Theory and Computation · 265
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Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product
1990 · Matthias Frech, Jacob John, et al. · Science · 245
Kinetics for Drug Discovery: an industry-driven effort to target drug residence time
2017 · Doris A. Schuetz, Wilhelmus Egbertus Arnout de Witte, et al. · Drug Discovery Today · 232
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Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction.
1988 · J John, M Frech, et al. · Journal of Biological Chemistry · 197
Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process
2006 · Kerstin Leykauf, Mojibrahman Salek, et al. · Journal of Cell Science · 140
Role of Glutamine-61 in the Hydrolysis of GTP by p21H-ras: An Experimental and Theoretical Study
1994 · M. Frech, T. A. Darden, et al. · Biochemistry · 138
Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline‐rich motifs.
1994 · D. Cussac, M. Frech, et al. · The EMBO Journal · 126
Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex
1999 · W.H. Ziegler, D.B. Parekh, et al. · Current Biology · 102
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Structural and Biophysical Characterization of the Syk Activation Switch
2012 · Ulrich Grädler, Daniel Schwarz, et al. · Journal of Molecular Biology · 91
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
2021 · Benedict-Tilman Berger, Marta Amaral, et al. · Cell chemical biology · 77
Specific Interaction of a Novel Foamy Virus Env Leader Protein with the N-Terminal Gag Domain
2001 · Thomas Wilk, Verena Geiselhart, et al. · Journal of Virology · 75
Affinity of guanine nucleotide binding proteins for their ligands: facts and artefacts
1991 · Roger S. Goody, Matthias Frech, et al. · Trends in Biochemical Sciences · 69
Production and Characterization of Saratin, an Inhibitor of von Willebrand Factor-Dependent Platelet Adhesion to Collagen
2001 · Christopher S. Barnes, Bianca Krafft, et al. · Seminars in Thrombosis and Hemostasis · 63
Nerve growth factor promotes activation of the α, β and γ isoforms of protein kinase B in PC12 pheochromocytoma cells
1998 · Mirjana Andjelković, Hana S. Suidan, et al. · European Journal of Biochemistry · 62
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Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors
2018 · Doris A. Schuetz, Lars Richter, et al. · Journal of Medicinal Chemistry · 59
Guanine nucleotide binding properties of the mammalian RalA protein produced in Escherichia coli.
1990 · M Frech, I Schlichting, et al. · Journal of Biological Chemistry · 52
Structure of the Leech Protein Saratin and Characterization of Its Binding to Collagen
2008 · Wolfram Gronwald, Jörg Bomke, et al. · Journal of Molecular Biology · 47
Features of the Env leader protein and the N-terminal Gag domain of feline foamy virus important for virus morphogenesis
2003 · Verena Geiselhart, Astrid Schwantes, et al. · Virology · 41
Binding of the h-ras p21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p21 GTPase activity in vitro
1992 · J. Serth, W. Weber, et al. · Biochemistry · 29
Works count: 46
Citation count: 6,326
H-index: 26
I10-index: 28
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