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Alain Matagne

Observed names: A MATAGNE, A Matagne, A. Matagne, ALAIN MATAGNE, Alain C. Matagne, Matagne, A
OpenAlex ID: A5071456969
The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam
2004 · Berkley A. Lynch, Nathalie Lambeng, et al. · Proceedings of the National Academy of Sciences · 1,625
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Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy
1998 · Henrik Klitgaard, Alain Matagne, et al. · European Journal of Pharmacology · 506
The anti‐epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA‐ and glycine‐gated currents
2002 · J‐M Rigo, G Hans, et al. · British Journal of Pharmacology · 335
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Binding characteristics of brivaracetam, a selective, high affinity SV2A ligand in rat, mouse and human brain: Relationship to anti-convulsant properties
2011 · Michel Gillard, Bruno Fuks, et al. · European Journal of Pharmacology · 256
The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes
1995 · Michel Noyer, Michel Gillard, et al. · European Journal of Pharmacology · 253
Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity
2003 · Benoit M. Kenda, Alain C. Matagne, et al. · Journal of Medicinal Chemistry · 226
Anti‐convulsive and anti‐epileptic properties of brivaracetam (ucb 34714), a high‐affinity ligand for the synaptic vesicle protein, SV2A
2008 · A Matagne, D‐G Margineanu, et al. · British Journal of Pharmacology · 225
Current understanding of the mechanism of action of the antiepileptic drug lacosamide
2014 · Michael A. Rogawski, Azita Tofighy, et al. · Epilepsy Research · 209
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Brivaracetam: Rationale for discovery and preclinical profile of a selective SV 2A ligand for epilepsy treatment
2016 · Henrik Klitgaard, Alain Matagne, et al. · Epilepsia · 171
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Brivaracetam, a selective high‐affinity synaptic vesicle protein 2A ( SV 2A) ligand with preclinical evidence of high brain permeability and fast onset of action
2015 · Jean‐Marie Nicolas, Jonas Hannestad, et al. · Epilepsia · 170
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SV2A protein is a broad-spectrum anticonvulsant target: Functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy
2007 · Rafal M. Kaminski, Alain Matagne, et al. · Neuropharmacology · 167
Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man
1998 · Alain Matagne, Henrik Klitgaard · Epilepsy Research · 127
Proepileptic phenotype of SV2A‐deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam
2009 · Rafal M. Kaminski, Michel Gillard, et al. · Epilepsia · 118
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Anticonvulsant effects of levetiracetam and levetiracetam–diazepam combinations in experimental status epilepticus
2004 · Andrey M Mazarati, Roger Baldwin, et al. · Epilepsy Research · 112
Benefit of combination therapy in epilepsy: A review of the preclinical evidence with levetiracetam
2008 · Rafal M. Kaminski, Alain Matagne, et al. · Epilepsia · 104
Pilocarpine-induced epileptogenesis in the rat:
2002 · Henrik Klitgaard, Alain Matagne, et al. · Epilepsy Research · 100
Electrophysiological, neurochemical and regional effects of levetiracetam in the rat pilocarpine model of temporal lobe epilepsy
2003 · HENRIK KLITGAARD, ALAIN MATAGNE, et al. · Seizure · 81
Seletracetam (UCB 44212)
2007 · Barbara Bennett, Alain Matagne, et al. · Neurotherapeutics · 59
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Low potency and limited efficacy of antiepileptic drugs in the mouse 6 Hz corneal kindling model
2014 · K. Leclercq, A. Matagne, et al. · Epilepsy Research · 58
Synergism of lacosamide with established antiepileptic drugs in the 6‐ H z seizure model in mice
2013 · Alexey Shandra, Pavel Shandra, et al. · Epilepsia · 55
Lacosamide treatment following status epilepticus attenuates neuronal cell loss and alterations in hippocampal neurogenesis in a rat electrical status epilepticus model
2013 · Thomas Licko, Natalie Seeger, et al. · Epilepsia · 48
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Pharmacological Profile of the Novel Antiepileptic Drug Candidate Padsevonil: Characterization in Rodent Seizure and Epilepsy Models
2019 · Karine Leclercq, Alain Matagne, et al. · Journal of Pharmacology and Experimental Therapeutics · 47
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Effects of chronic treatment with levetiracetam on hippocampal field responses after pilocarpine-induced status epilepticus in rats
2008 · Doru-Georg Margineanu, Alain Matagne, et al. · Brain Research Bulletin · 45
Use of epileptic animals for adverse effect testing
2002 · Henrik Klitgaard, Alain Matagne, et al. · Epilepsy Research · 45
Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy
2009 · Alain Matagne, Doru-Georg Margineanu, et al. · European Journal of Pharmacology · 36
Works count: 43
Citation count: 5,428
H-index: 29
I10-index: 33
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