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Jason Marineau

Observed names: J. Marineau, J.J. Marineau, Jason J Marineau, Jason J. Marineau, Marineau, Jason J.
Observed institutions: Boston College, Brigham and Women's Hospital, Harvard University, Pfizer (United States), Dana-Farber Cancer Institute, Syros Pharmaceuticals (United States)
ORCID: 0000-0002-4321-0038
Observed ORCID: 0000-0002-4321-0038
OpenAlex ID: A5071463273
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
2012 · Wenyu Yu, Emma J. Chory, et al. · Nature Communications · 292
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Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia
2014 · Alejandro Gutierrez, Li Pan, et al. · Journal of Clinical Investigation · 222
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Genome-wide localization of small molecules
2013 · Lars Anders, Matthew G Guenther, et al. · Nature Biotechnology · 184
Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7
2019 · Shanhu Hu, Jason J. Marineau, et al. · Cancer Research · 156
Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent
2016 · Michael Xiang, Haesook Kim, et al. · Blood · 114
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Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription
2020 · Jenna K. Rimel, Zachary C. Poss, et al. · Genes & Development · 101
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Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7
2021 · Jason J. Marineau, Kristin B. Hamman, et al. · Journal of Medicinal Chemistry · 99
Biased Multicomponent Reactions to Develop Novel Bromodomain Inhibitors
2014 · Michael R McKeown, Daniel L Shaw, et al. · Journal of Medicinal Chemistry · 93
Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement
2014 · Joanna S. Yi, Alexander J. Federation, et al. · ACS Chemical Biology · 24
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TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network
2025 · Taylor Jones, Junjie Feng, et al. · Science Advances · 14
Abstract 4421: SY-5609, an orally available selective CDK7 inhibitor demonstrates broad anti-tumor activity in vivo
2019 · Shanhu Hu, Jason Marineau, et al. · Cancer Research · 14
Abstract C091: Preclinical evaluation of PK, PD, and antitumor activity of the oral, non-covalent, potent and highly selective CDK7 inhibitor, SY-5609, provides rationale for clinical development in multiple solid tumor indications
2019 · Liv H Johannessen, Shanhu Hu, et al. · Molecular Cancer Therapeutics · 10
Expanding the medicinal chemistry toolbox: stereospecific generation of methyl group-containing propylene linkers
2006 · Kristopher Bosse, Jason Marineau, et al. · Tetrahedron Letters · 10
Abstract 4421: SY-5609, an orally available selective CDK7 inhibitor demonstrates broad anti-tumor activityin vivo
2019 · Shanhu Hu, Jason Marineau, et al. · Molecular and Cellular Biology / Genetics · 6
Development and Evaluation of a Solid-Supported Cyclobutadieneiron Tricarbonyl Complex for Parallel Synthesis Applications
2012 · Jason J. Marineau, Marc L. Snapper · ACS Combinatorial Science · 6
7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-en-2-ones: Readily accessible and highly potent anticancer compounds
2014 · Michael P. D’Erasmo, William B. Smith, et al. · Bioorganic & Medicinal Chemistry Letters · 4
Abstract 1143: Targeting the transcriptional kinases CDK12 and CDK13 in breast and ovarian cancer
2017 · Michael Bradley, Jason Marineau, et al. · Cancer Research · 3
Correction: Corrigendum: Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
2013 · Wenyu Yu, Emma J. Chory, et al. · Nature Communications · 3
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Targeting the transcriptional kinases CDK12 and CDK13 in breast and ovarian cancer
2017 · Kristin Hamman, Michael Bradley, et al. · The FASEB Journal · 2
Tag and Capture Flow Hydrogen Exchange Mass Spectrometry with a Fluorous-Immobilized Probe
2015 · Sean R. Marcsisin, Cary Liptak, et al. · Analytical Chemistry · 2
Phenothiazines Induce Apoptosis in T-Cell Acute Lymphoblastic Leukemia by Activating the Phosphatase Activity of the PP2A Tumor Suppressor
2012 · Alejandro Gutierrez, Alex Kentsis, et al. · Blood · 2
Abstract 5393: An oral and selective CDK12 inhibitor demonstrates robust anti-tumor activity
2022 · Shan hu, David Moebius, et al. · Cancer Research
CCDC 2093192: Experimental Crystal Structure Determination
2021 · Marineau, Jason J., Hamman, Kristin B., et al. · The Cambridge Structural Database
Abstract IA8: A new class of drugs active in T-ALL is revealed in a zebrafish screen
2014 · Alejandro Gutierrez, Li Pan, et al. · Molecular Cancer Research
Abstract 3230: Genome-wide localization of anti-cancer drugs
2014 · Lars Anders, Matthew G. Guenther, et al. · Cancer Research
Works count: 30
Citation count: 1,361
H-index: 11
I10-index: 13
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