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Robert C. Cumming
Observed names:
Cumming, Robert,
R.C. Cumming,
ROBERT C. CUMMING,
Robert C Cumming,
Robert Cumming
Institution:
Western University
Observed institutions:
Western University,
Salk Institute for Biological Studies,
Lawson Health Research Institute,
University of Ottawa,
London Health Sciences Centre,
Hospital for Sick Children,
Children’s Health Research Institute
show all 7
ORCID:
0000-0001-6821-7060
Observed ORCID:
0000-0001-6821-7060
OpenAlex ID:
A5071774128
Protein Disulfide Bond Formation in the Cytoplasm during Oxidative Stress
2004
·
Robert C. Cumming
, Nancy L. Andon
, et al.
·
Journal of Biological Chemistry
·
463
PDF
The Regulation of Glucose Metabolism by HIF-1 Mediates a Neuroprotective Response to Amyloid Beta Peptide
2003
·
Thomas Soucek
, Robert Cumming
, et al.
·
Neuron
·
258
PDF
Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1
2001
·
Robert C. Cumming
, Jeff Lightfoot
, et al.
·
Nature Medicine
·
245
Amyloid‐β induces disulfide bonding and aggregation of GAPDH in Alzheimer's disease
2005
·
Robert C. Cumming
, David Schubert
·
The FASEB Journal
·
147
Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect
2011
·
Jordan T. Newington
, Andrea Pitts
, et al.
·
PLoS ONE
·
121
PDF
Overexpression of Pyruvate Dehydrogenase Kinase 1 and Lactate Dehydrogenase A in Nerve Cells Confers Resistance to Amyloid β and Other Toxins by Decreasing Mitochondrial Respiration and Reactive Oxygen Species Production
2012
·
Jordan T. Newington
, Tim Rappon
, et al.
·
Journal of Biological Chemistry
·
118
PDF
blue cheeseMutations Define a Novel, Conserved Gene Involved in Progressive Neural Degeneration
2003
·
Kim D. Finley
, Philip T. Edeen
, et al.
·
Journal of Neuroscience
·
113
PDF
Reevaluating Metabolism in Alzheimer's Disease from the Perspective of the Astrocyte-Neuron Lactate Shuttle Model
2013
·
Jordan T. Newington
, Richard A. Harris
, et al.
·
Journal of Neurodegenerative Diseases
·
103
PDF
Aerobic Glycolysis in the Frontal Cortex Correlates with Memory Performance in Wild-Type Mice But Not the APP/PS1 Mouse Model of Cerebral Amyloidosis
2016
·
Richard A. Harris
, Lauren Tindale
, et al.
·
Journal of Neuroscience
·
101
PDF
Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts
2020
·
Alexandra M. Kozlov
, Asad Lone
, et al.
·
Scientific Reports
·
94
PDF
Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease
2014
·
Richard A. Harris
, Lauren Tindale
, et al.
·
Biogerontology
·
86
Attenuation of LDHA expression in cancer cells leads to redox-dependent alterations in cytoskeletal structure and cell migration
2013
·
Robert Arseneault
, Andrew Chien
, et al.
·
Cancer Letters
·
77
Lactate dehydrogenase expression modulates longevity and neurodegeneration in Drosophila melanogaster
2020
·
Dani M. Long
, Ariel K. Frame
, et al.
·
Aging
·
66
Increase in Expression Levels and Resistance to Sulfhydryl Oxidation of Peroxiredoxin Isoforms in Amyloid β-Resistant Nerve Cells
2007
·
Robert C. Cumming
, Richard Dargusch
, et al.
·
Journal of Biological Chemistry
·
61
Aerobic Glycolysis Is Required for Spatial Memory Acquisition But Not Memory Retrieval in Mice
2019
·
Richard A. Harris
, Asad Lone
, et al.
·
eNeuro
·
60
PDF
High temperature tolerance and thermal plasticity in emerald ash borer Agrilus planipennis
2011
·
Stephanie Sobek
, Arun Rajamohan
, et al.
·
Agricultural and Forest Entomology
·
45
p66Shc activation promotes increased oxidative phosphorylation and renders CNS cells more vulnerable to amyloid beta toxicity
2018
·
Asad Lone
, Richard A. Harris
, et al.
·
Scientific Reports
·
44
PDF
Dithiol-based Compounds Maintain Expression of Antioxidant Protein Peroxiredoxin 1 That Counteracts Toxicity of Mutant Huntingtin
2012
·
Andrea Pitts
, Kyle Dailey
, et al.
·
Journal of Biological Chemistry
·
36
PDF
Neural cells secrete a unique repertoire of proteins
2009
·
David Schubert
, Federico Herrera
, et al.
·
Journal of Neurochemistry
·
29
The association between oxidative stress-induced galectins and differentiation of human promyelocytic HL-60 cells
2017
·
James R. Vinnai
, Robert C. Cumming
, et al.
·
Experimental Cell Research
·
27
Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
2023
·
Ariel K. Frame
, J. Wesley Robinson
, et al.
·
Aging
·
21
PDF
Chapter Thirty‐Five Quantitative Analysis of Autophagic Activity in Drosophila Neural Tissues by Measuring the Turnover Rates of Pathway Substrates
2008
·
Robert C. Cumming
, Anne Simonsen
, et al.
·
Methods in enzymology on CD-ROM/Methods in enzymology
·
21
Abnormal Social Interactions in a Drosophila Mutant of an Autism Candidate Gene: Neuroligin 3
2020
·
Ryley T. Yost
, J. Wesley Robinson
, et al.
·
International Journal of Molecular Sciences
·
18
PDF
Altered neuronal lactate dehydrogenase A expression affects cognition in a sex- and age-dependent manner
2024
·
Ariel K. Frame
, Jessica L. Sinka
, et al.
·
iScience
·
14
Elongation factor 1A1 regulates metabolic substrate preference in mammalian cells
2024
·
Rachel B. Wilson
, Alexandra M. Kozlov
, et al.
·
Journal of Biological Chemistry
·
12
PDF
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Works count:
47
Citation count:
2,439
H-index:
21
I10-index:
28
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