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Niek G.J. Leus
Observed names:
Niek G J Leus,
Niek G. J. Leus,
Niek GJ Leus
Institution:
University of Groningen
Observed institutions:
University Medical Center Groningen,
University of Massachusetts Chan Medical School,
University of Groningen
OpenAlex ID:
A5072284653
Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation
2016
·
Niek GJ Leus
, Martijn RH Zwinderman
, et al.
·
Current Opinion in Chemical Biology
·
150
PDF
HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity
2016
·
Niek G.J. Leus
, Petra E. van der Wouden
, et al.
·
Biochemical Pharmacology
·
130
PDF
HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice
2017
·
Niek G. J. Leus
, Thea van den Bosch
, et al.
·
Scientific Reports
·
77
PDF
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases
2015
·
Thea van den Bosch
, Alexander Boichenko
, et al.
·
Biochemical Pharmacology
·
71
PDF
Anti-VCAM-1 SAINT-O-Somes enable endothelial-specific delivery of siRNA and downregulation of inflammatory genes in activated endothelium in vivo
2014
·
Piotr S. Kowalski
, Peter J. Zwiers
, et al.
·
Journal of Controlled Release
·
66
Anti-VCAM-1 and Anti-E-selectin SAINT-O-Somes for Selective Delivery of siRNA into Inflammation-Activated Primary Endothelial Cells
2013
·
Piotr S. Kowalski
, Lucas L. Lintermans
, et al.
·
Molecular Pharmaceutics
·
65
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties
2015
·
Nikolaos Eleftheriadis
, Constantinos G. Neochoritis
, et al.
·
Journal of Medicinal Chemistry
·
56
Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties
2016
·
Nikolaos Eleftheriadis
, Hessel Poelman
, et al.
·
European Journal of Medicinal Chemistry
·
50
PDF
Targeted siRNA delivery to diseased microvascular endothelial cells—Cellular and molecular concepts
2011
·
Piotr S. Kowalski
, Niek G. J. Leus
, et al.
·
IUBMB Life
·
34
Effective siRNA delivery to inflamed primary vascular endothelial cells by anti-E-selectin and anti-VCAM-1 PEGylated SAINT-based lipoplexes
2013
·
Niek G.J. Leus
, Eduard G. Talman
, et al.
·
International Journal of Pharmaceutics
·
30
A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices
2017
·
Thea van den Bosch
, Niek G.J. Leus
, et al.
·
Pulmonary Pharmacology & Therapeutics
·
25
PDF
Activity‐Based Probes for 15‐Lipoxygenase‐1
2016
·
Nikolaos Eleftheriadis
, Stephanie A. Thee
, et al.
·
Angewandte Chemie International Edition
·
24
VCAM-1 specific PEGylated SAINT-based lipoplexes deliver siRNA to activated endothelium in vivo but do not attenuate target gene expression
2014
·
Niek G.J. Leus
, Henriëtte W.M. Morselt
, et al.
·
International Journal of Pharmaceutics
·
24
ATM Increases Activation-Induced Cytidine Deaminase Activity at Downstream S Regions during Class-Switch Recombination
2014
·
Lyne Khair
, Jeroen E J Guikema
, et al.
·
The Journal of Immunology
·
16
Reassessment of the Role of Mut S Homolog 5 in Ig Class Switch Recombination Shows Lack of Involvement in cis- and trans-Switching
2008
·
Jeroen E J Guikema
, Carol E Schrader
, et al.
·
The Journal of Immunology
·
15
PDF
SAINT-liposome-polycation particles, a new carrier for improved delivery of siRNAs to inflamed endothelial cells
2014
·
Piotr S. Kowalski
, Praneeth R. Kuninty
, et al.
·
European Journal of Pharmaceutics and Biopharmaceutics
·
12
PDF
The relevance of K i calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor
2017
·
Hannah Wapenaar
, Thea van den Bosch
, et al.
·
European Journal of Medicinal Chemistry
·
11
PDF
Chemical epigenetics to assess the role of HDAC1–3 inhibition in macrophage pro-inflammatory gene expression
2016
·
Maria E. Ourailidou
, Niek G. J. Leus
, et al.
·
MedChemComm
·
7
PDF
Activity‐Based Probes for 15‐Lipoxygenase‐1
2016
·
Nikolaos Eleftheriadis
, Stephanie A. Thee
, et al.
·
Angewandte Chemie
·
6
Small Molecule Inhibitors of Histone Deacetylases and Acetyltransferases as Potential Therapeutics in Oncology
2016
·
Thea van den Bosch
, Niek G.J. Leus
, et al.
·
Elsevier eBooks
·
2
SAINTargs, a novel lipid-based targeting device for siRNA delivery
2010
·
Niek G.J. Leus
, Piotr S. Kowalski
, et al.
·
Drug Discovery Today
·
1
Targeted SAINT-O-Somes, a novel type of liposomes for improved delivery of siRNA
2010
·
Piotr S. Kowalski
, Niek G.J. Leus
, et al.
·
Drug Discovery Today
·
1
List of Contributors
2016
·
Paola Arimondo
, Dina Arvanitis
, et al.
·
Elsevier eBooks
Endothelial-specific delivery of siRNA by novel SAINT-based lipoplexes
2014
·
Niek G.J. Leus
Endothelial-specific delivery of siRNA by novel SAINT-based lipoplexes: an in vitro and in vivo study
2014
·
Niek G.J. Leus
·
University of Groningen research database (University of Groningen / Centre for Information Technology)
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Works count:
25
Citation count:
873
H-index:
15
I10-index:
17
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