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Babita Madan

Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer
2012 · Kyle David Proffitt, Babita Madan, et al. · Cancer Research · 383
Wnt addiction of genetically defined cancers reversed by PORCN inhibition
2015 · B Madan, Z Ke, et al. · Oncogene · 342
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Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts
2014 · Zahra Kabiri, Gediminas Greicius, et al. · Development · 339
SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies
2011 · S Hart, K C Goh, et al. · Leukemia · 204
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Pacritinib (SB1518), a JAK2/FLT3 inhibitor for the treatment of acute myeloid leukemia
2011 · S Hart, K C Goh, et al. · Blood Cancer Journal · 117
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Targeting Wnts at the Source—New Mechanisms, New Biomarkers, New Drugs
2015 · Babita Madan, David M. Virshup · Molecular Cancer Therapeutics · 113
Isoliquiritigenin inhibits IκB kinase activity and ROS generation to block TNF-α induced expression of cell adhesion molecules on human endothelial cells
2007 · Sarvesh Kumar, Amit Sharma, et al. · Biochemical Pharmacology · 113
USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds
2016 · Babita Madan, Matthew P. Walker, et al. · Proceedings of the National Academy of Sciences · 110
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Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy
2018 · Babita Madan, Mitchell J. McDonald, et al. · Bone Research · 101
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Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog Mll5
2008 · Vikas Madan, Babita Madan, et al. · Blood · 92
PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers
2019 · Zheng Zhong, Sugunavathi Sepramaniam, et al. · Oncogene · 88
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2′-Hydroxychalcone Inhibits Nuclear Factor-κB and Blocks Tumor Necrosis Factor-α- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells
2000 · Babita Madan, Sanjay Batra, et al. · Molecular Pharmacology · 80
Wnts and the hallmarks of cancer
2020 · Zheng Zhong, Jia Yu, et al. · Cancer and Metastasis Reviews · 79
TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome
2015 · Sebastian Ribi, Daniel Baumhoer, et al. · Oncotarget · 77
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VS-5584, a Novel and Highly Selective PI3K/mTOR Kinase Inhibitor for the Treatment of Cancer
2012 · Stefan Hart, Veronica Novotny-Diermayr, et al. · Molecular Cancer Therapeutics · 74
Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis
2018 · Babita Madan, Nathan Harmston, et al. · Journal of Clinical Investigation · 68
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The Pluripotency-Associated GeneDppa4Is Dispensable for Embryonic Stem Cell Identity and Germ Cell Development but Essential for Embryogenesis
2009 · Babita Madan, Vikas Madan, et al. · Molecular and Cellular Biology · 65
Polarized helper T cells in tubercular pleural effusion: phenotypic identity and selective recruitment
2005 · Dipendra K. Mitra, Surendra K. Sharma, et al. · European Journal of Immunology · 65
WNT inhibition creates a BRCA‐like state in Wnt‐addicted cancer
2021 · Amanpreet Kaur, Sugunavathi Sepramaniam, et al. · EMBO Molecular Medicine · 63
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Discovery of the Macrocycle (9E)-15-(2-(Pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triaza-tetracyclo[18.3.1.1(2,5).1(14,18)]hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene (SB1578), a Potent Inhibitor of Janus Kinase 2/Fms-LikeTyrosine Kinase-3 (JAK2/FLT3) for the Treatment of Rheumatoid Arthritis
2012 · Anthony D. William, Angeline C.-H. Lee, et al. · Journal of Medicinal Chemistry · 57
Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis
2016 · Babita Madan, Mehul B. Patel, et al. · Kidney International · 55
The Functional Landscape of Patient-Derived RNF43 Mutations Predicts Sensitivity to Wnt Inhibition
2020 · Jia Yu, Permeen A. Mohamed Yusoff, et al. · Cancer Research · 53
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Diferuloylmethane Inhibits Neutrophil Infiltration and Improves Survival of Mice in High-Dose Endotoxin Shock
2003 · Babita Madan, Balaram Ghosh · Shock · 44
A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models
2022 · Zheng Zhong, Nathan Harmston, et al. · Journal of Clinical Investigation · 40
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First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours.
2017 · Matthew Ng, David SP Tan, et al. · Journal of Clinical Oncology · 38
Works count: 104
Citation count: 3,331
H-index: 32
I10-index: 44
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