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Ivan H. Chan

IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance
2011 · John B. Mumm, Jan Emmerich, et al. · Cancer Cell · 438
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IL-10 Directly Activates and Expands Tumor-Resident CD8+ T Cells without De Novo Infiltration from Secondary Lymphoid Organs
2012 · Jan Emmerich, John B. Mumm, et al. · Cancer Research · 281
PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients
2018 · Aung Naing, Jeffrey R. Infante, et al. · Cancer Cell · 263
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Safety, Antitumor Activity, and Immune Activation of Pegylated Recombinant Human Interleukin-10 (AM0010) in Patients With Advanced Solid Tumors
2016 · Aung Naing, Kyriakos P. Papadopoulos, et al. · Journal of Clinical Oncology · 227
Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells
2013 · I H Chan, R Jain, et al. · Mucosal Immunology · 147
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Isoform-Specific Transcriptional Activity of Overlapping Target Genes that Respond to Thyroid Hormone Receptors α1 and β1
2009 · Ivan H. Chan, Martin L. Privalsky · Molecular Endocrinology · 83
Thyroid hormone receptors mutated in liver cancer function as distorted antimorphs
2006 · I H Chan, M L Privalsky · Oncogene · 60
Thyroid hormone receptor mutants implicated in human hepatocellular carcinoma display an altered target gene repertoire
2009 · I H Chan, M L Privalsky · Oncogene · 38
The Potentiation of IFN-γ and Induction of Cytotoxic Proteins by Pegylated IL-10 in Human CD8 T Cells
2015 · Ivan Ho Chan, Victoria Wu, et al. · Journal of Interferon & Cytokine Research · 34
A Mechanism for Pituitary-Resistance to Thyroid Hormone (PRTH) Syndrome: a Loss in Cooperative Coactivator Contacts by Thyroid Hormone Receptor (TR)β2
2011 · Sangho Lee, Briana M. Young, et al. · Molecular Endocrinology · 34
Mutant Thyroid Hormone Receptors (TRs) Isolated from Distinct Cancer Types Display Distinct Target Gene Specificities: A Unique Regulatory Repertoire Associated with Two Renal Clear Cell Carcinomas
2011 · Meghan D. Rosen, Ivan H. Chan, et al. · Molecular Endocrinology · 24
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Abstract 4235: A combination of CAR-NK and CAR-T cells results in rapid and persistent anti-tumor efficacy while reducing CAR-T cell mediated cytokine release and T-cell proliferation
2020 · Guangnan Li, Xiumin Wu, et al. · Cancer Research · 19
The p160 Coactivator PAS-B Motif Stabilizes Nuclear Receptor Binding and Contributes to Isoform-specific Regulation by Thyroid Hormone Receptors
2009 · Martin L. Privalsky, Sangho Lee, et al. · Journal of Biological Chemistry · 19
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31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
2016 · Casey Ager, Matthew Reilley, et al. · Journal for ImmunoTherapy of Cancer · 17
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PEG-rIL-10 treatment decreases FoxP3+Tregs despite upregulation of intratumoral IDO
2016 · Ivan H. Chan, Victoria Wu, et al. · OncoImmunology · 14
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PEGylated IL-10 Activates Kupffer Cells to Control Hypercholesterolemia
2016 · Ivan H. Chan, Dennis Van Hoof, et al. · PLoS ONE · 12
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A Conserved Lysine in the Thyroid Hormone Receptor–α1 DNA-Binding Domain, Mutated in Hepatocellular Carcinoma, Serves as a Sensor for Transcriptional Regulation
2010 · Ivan H. Chan, Martin L. Privalsky · Molecular Cancer Research · 12
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Abstract 5512: CBLB, CISH and CD70 multiplexed gene knockout with CRISPR/Cas9 enhances cytotoxicity of CD70-CAR NK cells and provides greater resistance to TGF-β for cancer immunotherapy
2022 · Chao Guo, Yanying Fan, et al. · Cancer Research · 8
127 Preclinical evaluation of NKX019, a CD19-targeting CAR NK Cell
2020 · Nadege Morisot, Sarah Wadsworth, et al. · Journal for ImmunoTherapy of Cancer · 8
Clinical activity and safety of pegylated human IL-10 (AM0010) in combination with anti-PD1.
2016 · Aung Naing, Kyriakos P. Papadopoulos, et al. · Journal of Clinical Oncology · 8
IL-10: Expanding the Immune Oncology Horizon
2015 · Ivan H Chan, Victoria Wu, et al. · Receptors & Clinical Investigation · 8
Anti-tumor activity of PEGylated human IL-10 (AM0010) in patients with pancreatic or colorectal cancer.
2016 · Kyriakos P. Papadopoulos, Aung Naing, et al. · Journal of Clinical Oncology · 7
A Cautionary Note as to the Use of pBi-L and Related Luciferase/Transgenic Vectors in the Study of Thyroid Endocrinology
2008 · Ivan H. Chan, Alexander D. Borowsky, et al. · Thyroid · 7
Abstract 890: ADAM17 knockout NK or CAR NK cells augment antibody dependent cellular cytotoxicity (ADCC) and anti-tumor activity
2023 · Chao Guo, Yanying Fan, et al. · Cancer Research · 5
113 CISH gene-knockout anti-CD70-CAR NK cells demonstrate potent anti-tumor activity against solid tumor cell lines and provide partial resistance to tumor microenvironment inhibition
2021 · Chao Guo, Yanying Fan, et al. · Journal for ImmunoTherapy of Cancer · 4
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Works count: 39
Citation count: 1,787
H-index: 14
I10-index: 17
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