Get started
Author

Christoffer Bundgaard

Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator
2014 · Kenji Maeda, Haruhiko Sugino, et al. · Journal of Pharmacology and Experimental Therapeutics · 382
Pharmacological Effects of Lu AA21004: A Novel Multimodal Compound for the Treatment of Major Depressive Disorder
2011 · A. Mørk, A. Pehrson, et al. · Journal of Pharmacology and Experimental Therapeutics · 285
DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo
2018 · Karen J. Thompson, Elham Khajehali, et al. · ACS Pharmacology & Translational Science · 201
PDF
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
2022 · Irena Loryan, Andreas Reichel, et al. · Pharmaceutical Research · 158
PDF
Brexpiprazole II: Antipsychotic-Like and Procognitive Effects of a Novel Serotonin-Dopamine Activity Modulator
2014 · Kenji Maeda, Linda Lerdrup, et al. · Journal of Pharmacology and Experimental Therapeutics · 137
Structure−Activity Relationship Study of First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101)
2010 · Mette N. Erichsen, Tri H. V. Huynh, et al. · Journal of Medicinal Chemistry · 124
From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease
2021 · Alastair J.H. Brown, Sophie J. Bradley, et al. · Cell · 104
Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of d-Serine in the Forebrain
2016 · Hagit Sason, Jean Marie Billard, et al. · Cerebral Cortex · 74
Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist
2017 · Anders A. Jensen, John D. McCorvy, et al. · Journal of Pharmacology and Experimental Therapeutics · 67
A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons
2017 · Sharon A. Swanger, Katie M. Vance, et al. · ACS Chemical Neuroscience · 65
A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)
2015 · Harriet Hammer, Benjamin M. Bader, et al. · Molecular Pharmacology · 64
Antipsychotic-Like Effect of Retigabine [N-(2-Amino-4-(fluorobenzylamino)-phenyl)carbamic Acid Ester], a KCNQ Potassium Channel Opener, via Modulation of Mesolimbic Dopaminergic Neurotransmission
2008 · Florence Sotty, Trine Damgaard, et al. · Journal of Pharmacology and Experimental Therapeutics · 61
Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats
2011 · John P. Redrobe, Lisbeth Elster, et al. · Psychopharmacology · 60
Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors
2011 · Jan Kehler, Andreas Ritzen, et al. · Bioorganic & Medicinal Chemistry Letters · 55
The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin
2013 · Tenna Juul Schrøder, Søren Christensen, et al. · Bioorganic & Medicinal Chemistry Letters · 54
Species Comparison of In Vivo P-Glycoprotein-Mediated Brain Efflux Using mdr1a-Deficient Rats and Mice
2011 · Christoffer Bundgaard, Christian Jes Nyberg Jensen, et al. · Drug Metabolism and Disposition · 54
In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: potential relevance to cognitive deficits in schizophrenia
2014 · John P. Redrobe, Morten Jørgensen, et al. · Psychopharmacology · 46
P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood–brain barrier in vivo
2015 · Christoffer Bundgaard, Elin Eneberg, et al. · Neuropharmacology · 42
Mechanistic model of acute autoinhibitory feedback action after administration of SSRIs in rats: Application to escitalopram-induced effects on brain serotonin levels
2006 · Christoffer Bundgaard, Frank Larsen, et al. · European Journal of Pharmaceutical Sciences · 41
The synthesis and SAR of 2-arylsulfanylphenyl-1-oxyalkylamino acids as GlyT-1 inhibitors
2006 · Garrick Smith, Gitte Mikkelsen, et al. · Bioorganic & Medicinal Chemistry Letters · 41
Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods
2016 · Klaus Gjervig Jensen, Anne-Marie Jacobsen, et al. · Drug Metabolism and Disposition · 40
The 5-HT6 receptor antagonist idalopirdine potentiates the effects of acetylcholinesterase inhibition on neuronal network oscillations and extracellular acetylcholine levels in the rat dorsal hippocampus
2016 · Kjartan F. Herrik, Arne Mørk, et al. · Neuropharmacology · 39
PDF
Discovery of Phosphoric Acid Mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070): A Phosphonooxymethylene Prodrug of a Potent and Selective hA2AReceptor Antagonist
2011 · Anette G. Sams, Gitte K. Mikkelsen, et al. · Journal of Medicinal Chemistry · 39
De novo design of miniproteins targeting GPCRs
2026 · Edin Muratspahić, David Feldman, et al. · Nature · 38
Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats
2017 · Morten Laursen, Lilliana Beck, et al. · British Journal of Pharmacology · 38
Works count: 117
Citation count: 3,390
H-index: 32
I10-index: 72
Year
Topic
Type