Author

Edward L.Y. Chen

Observed names: Edward L Y Chen, Edward L. Chen, Edward L. Y. Chen, Edward L.Y. Chen (20982441)

Institutions: University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sunnybrook Hospital, Sunnybrook Research Institute

Observed institutions: Mount Sinai Hospital, Sunnybrook Health Science Centre, University of Toronto, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Sunnybrook Hospital, Sunnybrook Research Institute

ORCID: 0000-0001-7197-2243

Observed ORCID: 0000-0001-7197-2243

OpenAlex ID: A5076180718

Single-cell atlas of the human brain vasculature across development, adulthood and disease

2024 · Thomas Wälchli, Moheb Ghobrial, et al. · Nature · 179

RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors

2019 · Edward L. Y. Chen, Patrycja K. Thompson, et al. · Nature Immunology · 93

Generation and molecular recognition of melanoma-associated antigen-specific human γδ T cells

2018 · Patricia M. Benveniste, Sobhan Roy, et al. · Science Immunology · 77

HEB is required for the specification of fetal IL-17-producing γδ T cells

2017 · Tracy S. H. In, Ashton Trotman-Grant, et al. · Nature Communications · 65

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Gamma delta T-cell differentiation and effector function programming, TCR signal strength, when and how much?

2015 · Payam Zarin, Edward L.Y. Chen, et al. · Cellular Immunology · 50

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

2023 · Dzana Dervovic, Ahmad A. Malik, et al. · Nature Communications · 45

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NOTCH1 signaling establishes the medullary thymic epithelial cell progenitor pool during mouse fetal development

2020 · Jie Li, Julie Gordon, et al. · Development · 31

Ontogenic timing, T cell receptor signal strength, and Notch signaling direct γδ T cell functional differentiation in vivo

2021 · Edward L.Y. Chen, Christina R. Lee, et al. · Cell Reports · 27

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Generation and function of progenitor T cells from StemRegenin-1–expanded CD34+ human hematopoietic progenitor cells

2019 · Jastaranpreet Singh, Edward L. Y. Chen, et al. · Blood Advances · 24

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Peroxisome Proliferator-Activated Receptor–δ Supports the Metabolic Requirements of Cell Growth in TCRβ-Selected Thymocytes and Peripheral CD4+ T Cells

2018 · Fei Linda Zhao, Jeeyoon Jennifer Ahn, et al. · The Journal of Immunology · 19

Segmentation aware probabilistic phenotyping of single-cell spatial protein expression data

2025 · Yuju Lee, Edward L. Y. Chen, et al. · Nature Communications · 13

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Cutting Edge: TCR-β Selection Is Required at the CD4+CD8+ Stage of Human T Cell Development

2021 · Edward L Y Chen, Patrick M Brauer, et al. · The Journal of Immunology · 7

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T Cell Development: From T-Lineage Specification to Intrathymic Maturation

2025 · Mahdieh Golzari-Sorkheh, Kogulan Yoganathan, et al. · Advances in experimental medicine and biology · 6

T-Cell Development: From T-Lineage Specification to Intrathymic Maturation

2019 · Kogulan Yoganathan, Edward L. Y. Chen, et al. · Springer eBooks · 6

CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment

2025 · Douglas C. Chung, Noor Shakfa, et al. · Cancer Immunology Research · 5

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Realization of the T Lineage Program Involves GATA-3 Induction of Bcl11b and Repression of Cdkn2b Expression

2022 · Patrycja K Thompson, Edward L Y Chen, et al. · The Journal of Immunology · 5

Author Correction: In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

2023 · Dzana Dervovic, Ahmad A. Malik, et al. · Nature Communications · 4

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Abstract PR007: Integrated spatial proteomics of human PDAC uncovers an expanded tumour-immune-stroma spectrum with genomic associations

2026 · Noor Shakfa, Ferris Nowlan, et al. · Cancer Research

Supplementary Figure S4 from CD103+CD56+ ILCs Are Associated with an Altered CD8+ T-cell Profile within the Tumor Microenvironment