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Masashi Mima

Observed name: M. Mima
ORCID: 0000-0003-2336-9129
Observed ORCID: 0000-0003-2336-9129
OpenAlex ID: A5076467277
Lead Identification of 8-(Methylamino)-2-oxo-1,2-dihydroquinoline Derivatives as DNA Gyrase Inhibitors: Hit-to-Lead Generation Involving Thermodynamic Evaluation
2020 · Fumihito Ushiyama, Hideaki Amada, et al. · ACS Omega · 72
Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity
2020 · Yousuke Yamada, Hajime Takashima, et al. · Journal of Medicinal Chemistry · 34
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Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532
2020 · Fumihito Ushiyama, Hajime Takashima, et al. · Bioorganic & Medicinal Chemistry · 31
Discovery of Aryloxyphenyl–Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
2022 · Tomoki Takeuchi, Masato Hayashi, et al. · Journal of Medicinal Chemistry · 27
Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide–Pentapeptide Hybrid Scaffold
2023 · Tomoki Takeuchi, Yusaku Nomura, et al. · Journal of Medicinal Chemistry · 23
Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors
2020 · Fumihito Ushiyama, Hideaki Amada, et al. · Bioorganic & Medicinal Chemistry · 22
Unique structure of ozoralizumab, a trivalent anti-TNFα NANOBODY® compound, offers the potential advantage of mitigating the risk of immune complex-induced inflammation
2023 · Masanao Kyuuma, Ayaka Kaku, et al. · Frontiers in Immunology · 21
Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor
2022 · Yudai Imai, Daisuke Wakasugi, et al. · Bioorganic & Medicinal Chemistry Letters · 12
Structural design of the anti-TNFα therapeutic NANOBODY® compound, ozoralizumab, to support its potent and sustained clinical efficacy
2024 · Masashi Mima, Chiemi Mishima-Tsumagari, et al. · Biochemical and Biophysical Research Communications · 11
Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation
2023 · Rie Nishikawa-Shimono, Motoi Kuwabara, et al. · Bioorganic & Medicinal Chemistry Letters · 11
Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor
2023 · Yudai Imai, Ryo Suzuki, et al. · Bioorganic & Medicinal Chemistry · 7
Crystal structure of E.coli DNA gyrase B in complex with 2-oxo-1,2-dihydroquinoline derivative
2019 · M. Mima, F. Ushiyama · Worldwide Protein Data Bank · 4
Crystallization and preliminary X-ray crystallographic analysis of Ca2+-free primary Ca2+-sensor of Na+/Ca2+exchanger
2008 · Masashi Mima, Chika Kawai, et al. · Acta Crystallographica Section F Structural Biology and Crystallization Communications · 3
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Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors
2026 · Masashi Mima, Chiemi Mishima-Tsumagari, et al. · Acta Crystallographica Section F Structural Biology Communications
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Cryo-EM elucidates the interaction mechanism of ozoralizumab, a humanized anti-TNFα NANOBODY® compound
2026 · Masashi Mima, Kyohei Sato, et al. · Biochemical and Biophysical Research Communications
Cryo-EM structure of the TNF-alpha-Ozoralizumab (OZR)-HSA complex
2025 · Y. Tanaka, K. Sato, et al. · Worldwide Protein Data Bank
Cryo-EM structure of TNF-alpha in complex with two anti-TNF-alpha nanobodies, TNF30, derived from the TNF-alpha inhibitor Ozoralizumab (OZR)
2025 · Y. Tanaka, K. Sato, et al. · Worldwide Protein Data Bank
Crystal structure of E.coli DNA gyrase B in complex with 6-fluoro-8-(methylamino)-2-oxo-1,2-dihydroquinoline derivative
2020 · M. Mima, F. Ushiyama · Worldwide Protein Data Bank
Crystallization and preliminary X-ray analysis of Ca2+-free primary Ca2+-sensor of Na+/Ca2+exchanger
2008 · K. Tomoo, M. Mima, et al. · Acta Crystallographica Section A Foundations of Crystallography
Works count: 24
Citation count: 279
H-index: 10
I10-index: 10
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