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Dean J. Derbyshire

Observed names: D. Derbyshire, D. J. Derbyshire, D.J. Derbyshire, Dean Derbyshire, Dean J Derbyshire, Derbyshire, Dean
Observed institutions: Linköping University, AstraZeneca (United Kingdom), MRC Laboratory of Molecular Biology, University of Cambridge, Medivir (Sweden), University of Florence
ORCID: 0000-0001-5688-1415
Observed ORCID: 0000-0001-5688-1415
OpenAlex ID: A5076805040
N-acetylgalactosamine on the putative insect receptor aminopeptidase N is recognised by a site on the domain III lectin-like fold of a Bacillus thuringiensis insecticidal toxin
1999 · Sarah L Burton, David J Ellar, et al. · Journal of Molecular Biology · 200
Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor
2002 · Dean J. Derbyshire, Balaku P. Basu, et al. · The EMBO Journal · 185
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X-ray Structure of Recombinant Ricin A-Chain at 1.8 Å Resolution
1994 · Simon A. Weston, Alec D. Tucker, et al. · Journal of Molecular Biology · 111
Structural implications for the transformation of the Bacillus thuringiensis δ-endotoxins from water-soluble to membrane-inserted forms
2001 · J. Li, D. J. Derbyshire, et al. · Biochemical Society Transactions · 70
Crystallization of theBacillus thuringiensistoxin Cry1Ac and its complex with the receptor ligandN-acetyl- D -galactosamine
2001 · Dean J. Derbyshire, David J. Ellar, et al. · Acta Crystallographica Section D Biological Crystallography · 61
NMR trial models: experiences with the colicin immunity protein Im7 and the p85α C-terminal SH2–peptide complex
2001 · Richard A. Pauptit, Caitríona A. Dennis, et al. · Acta Crystallographica Section D Biological Crystallography · 35
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Design and synthesis of potent macrocyclic renin inhibitors
2010 · Christian Sund, Oscar Belda, et al. · Bioorganic & Medicinal Chemistry Letters · 17
Discovery of USP7 small-molecule allosteric inhibitors
2020 · Olof Engström, Oscar Belda, et al. · Bioorganic & Medicinal Chemistry Letters · 14
Purification, crystallization and preliminary X-ray analysis of the BRCT domains of human 53BP1 bound to the p53 tumour suppressor
2002 · Dean J. Derbyshire, Balaku P. Basu, et al. · Acta Crystallographica Section D Biological Crystallography · 11
Transthyretin Binding Mode Dichotomy of Fluorescent trans-Stilbene Ligands
2023 · Afshan Begum, Jun Zhang, et al. · ACS Chemical Neuroscience · 10
Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates
2012 · Christian Sund, Oscar Belda, et al. · Bioorganic & Medicinal Chemistry Letters · 10
Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases
2009 · Johan Isaksson, Susanne Nyström, et al. · Journal of Medicinal Chemistry · 6
The N-Myc MB0-MBI region interacts specifically and dynamically with the N-lobe of Aurora kinase A
2026 · Johanna Hultman, Vivian Morad, et al. · Nature Communications · 4
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Binding of a Pyrene-Based Fluorescent Amyloid Ligand to Transthyretin: A Combined Crystallographic and Molecular Dynamics Study
2023 · Nghia Nguyen Thi Minh, Afshan Begum, et al. · The Journal of Physical Chemistry B · 3
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Dynamic networks connect the USP14 active site region with the proteasome interaction surface
2025 · Johannes Salomonsson, Linda Sjöstrand, et al. · Protein Science · 2
Antibacterial Design Based on the Structures of Gyrase-Inhibitor Complexes
1998 · Richard Pauptit, Simon Weston, et al. · Springer eBooks · 2
Lepidoptera-specific toxin Cry1Ac from Bacillus thuringiensis ssp. kurstaki HD-73
2012 · D.J. Derbyshire, J. Carroll, et al. · Worldwide Protein Data Bank · 1
Immunoconjugates as Anti-Cancer Agents
1998 · Richard Pauptit, Simon Weston, et al. · Springer eBooks · 1
Richard Alexander Pauptit 1954–2024
2024 · Caitriona Dennis, Dean Derbyshire, et al. · Acta Crystallographica Section F Structural Biology Communications
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Dynamic regions allosterically connect the USP14 active site with the proteasome interaction surface
2024 · Johannes Salomonsson, Linda Sjöstrand, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Cathepsin-K in complex with MIV-701
2019 · D.J. Derbyshire · Worldwide Protein Data Bank
Cathepsin-K in complex with fluoro-oxa-azabicyclo[3.3.0]octanyl containing inhibitor
2019 · D.J. Derbyshire · Worldwide Protein Data Bank
Cathepsin-K in complex with MIV-711
2019 · D.J. Derbyshire · Worldwide Protein Data Bank
Characterization of fragment hits interacting with MMP-12 reveals a dimerised adduct of a fragment hit in the active site
2013 · Helena Nordström, D.J. Derbyshire, et al.
BACE-1 in complex with HEA-type macrocyclic inhibitor, MV078571
2012 · J.D. Lindberg, D. Derbyshire · Worldwide Protein Data Bank
Works count: 38
Citation count: 743
H-index: 10
I10-index: 11
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