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Deepak Gurbani

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations
2015 · John C. Hunter, Anuj Manandhar, et al. · Molecular Cancer Research · 804
TiO2nanoparticles induce oxidative DNA damage and apoptosis in human liver cells
2011 · Ritesh K Shukla, Ashutosh Kumar, et al. · Nanotoxicology · 246
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
2014 · John C. Hunter, Deepak Gurbani, et al. · Proceedings of the National Academy of Sciences · 245
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Pharmacological targeting of the pseudokinase Her3
2014 · Ting Xie, Sang Min Lim, et al. · Nature Chemical Biology · 204
MicroRNA-218 functions as a tumor suppressor in lung cancer by targeting IL-6/STAT3 and negatively correlates with poor prognosis
2017 · Yan Yang, Lili Ding, et al. · Molecular Cancer · 150
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Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease
2017 · Juliane Totzke, Deepak Gurbani, et al. · Cell chemical biology · 144
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Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine
2016 · Wayne Harshbarger, Sudershan Gondi, et al. · Journal of Biological Chemistry · 91
Discovery of Type II Inhibitors of TGFβ-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2)
2014 · Li Tan, Tyzoon Nomanbhoy, et al. · Journal of Medicinal Chemistry · 74
Polycyclic aromatic hydrocarbons and their quinones modulate the metabolic profile and induce DNA damage in human alveolar and bronchiolar cells
2013 · Deepak Gurbani, Santosh Kumar Bharti, et al. · International Journal of Hygiene and Environmental Health · 73
Development of small molecules targeting the pseudokinase Her3
2015 · Sang Min Lim, Ting Xie, et al. · Bioorganic & Medicinal Chemistry Letters · 68
Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome
2019 · Suman Rao, Deepak Gurbani, et al. · Cell chemical biology · 67
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In silico studies with human DNA topoisomerase-II alpha to unravel the mechanism of in vitro genotoxicity of benzene and its metabolites
2008 · Alok Kumar Pandey, Deepak Gurbani, et al. · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 43
Mechanism of Inhibition of the ATPase Domain of Human Topoisomerase IIα by 1,4-Benzoquinone, 1,2-Naphthoquinone, 1,4-Naphthoquinone, and 9,10-Phenanthroquinone
2012 · Deepak Gurbani, Vandna Kukshal, et al. · Toxicological Sciences · 42
Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine
2020 · Guangyan Du, Suman Rao, et al. · Journal of Medicinal Chemistry · 39
A highly selective inhibitor of interleukin-1 receptor–associated kinases 1/4 (IRAK-1/4) delineates the distinct signaling roles of IRAK-1/4 and the TAK1 kinase
2019 · Scott A. Scarneo, Philip F. Hughes, et al. · Journal of Biological Chemistry · 33
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Structure-guided development of covalent TAK1 inhibitors
2016 · Li Tan, Deepak Gurbani, et al. · Bioorganic & Medicinal Chemistry · 33
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1
2023 · Wenchao Lu, Yao Liu, et al. · Journal of Medicinal Chemistry · 32
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Structure and Characterization of a Covalent Inhibitor of Src Kinase
2020 · Deepak Gurbani, Guangyan Du, et al. · Frontiers in Molecular Biosciences · 31
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Structural basis of the atypical activation mechanism of KRASV14I
2019 · Asim K. Bera, Jia Lu, et al. · Journal of Biological Chemistry · 31
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C60-Fullerene Binds with the ATP Binding Domain of Human DNA Topoiosmerase II Alpha
2011 · Lokesh Baweja, Deepak Gurbani, et al. · Journal of Biomedical Nanotechnology · 30
In-Vivo Efficacy of Compliant 3D Nano-Composite in Critical-Size Bone Defect Repair: a Six Month Preclinical Study in Rabbit
2013 · Nitin Sagar, Alok K. Pandey, et al. · PLoS ONE · 23
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Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors
2016 · Li Tan, Deepak Gurbani, et al. · Bioorganic & Medicinal Chemistry · 22
Interaction of C60 Fullerene with the Proteins Involved in DNA Mismatch Repair Pathway
2011 · Shishir Kumar Gupta, Lokesh Baweja, et al. · Journal of Biomedical Nanotechnology · 21
The nonreceptor tyrosine kinase SRMS inhibits autophagy and promotes tumor growth by phosphorylating the scaffolding protein FKBP51
2021 · Jung Mi Park, Seung Wook Yang, et al. · PLoS Biology · 13
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Structural dataset for the fast-exchanging KRAS G13D
2015 · Jia Lu, John Hunter, et al. · Data in Brief · 6
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Works count: 58
Citation count: 2,570
H-index: 22
I10-index: 24
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