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Todd Holyoak

Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection
2008 · Sarah M. Sullivan, Todd Holyoak · Proceedings of the National Academy of Sciences · 167
The Min Oscillator Uses MinD-Dependent Conformational Changes in MinE to Spatially Regulate Cytokinesis
2011 · Kyung-Tae Park, Wei Wu, et al. · Cell · 163
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Determination of the structure of the MinD–ATP complex reveals the orientation of MinD on the membrane and the relative location of the binding sites for MinE and MinC
2011 · Wei Wu, Kyung‐Tae Park, et al. · Molecular Microbiology · 114
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2.4 Å Resolution Crystal Structure of the Prototypical Hormone-Processing Protease Kex2 in Complex with an Ala-Lys-Arg Boronic Acid Inhibitor ,
2003 · Todd Holyoak, Mark A. Wilson, et al. · Biochemistry · 81
Differentiating a Ligand's Chemical Requirements for Allosteric Interactions from Those for Protein Binding. Phenylalanine Inhibition of Pyruvate Kinase ,
2006 · Rachel Williams, Todd Holyoak, et al. · Biochemistry · 79
Structural Insights into the Mechanism of PEPCK Catalysis,
2006 · Todd Holyoak, Sarah M. Sullivan, et al. · Biochemistry · 76
Active-Site Gating Regulates Substrate Selectivity in a Chymotrypsin-Like Serine Protease
2009 · Troy A. Johnson, Jiazhou Qiu, et al. · Journal of Molecular Biology · 74
Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith–Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity
2014 · David R. Adams, Hongjie Yuan, et al. · Molecular Genetics and Metabolism · 65
Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella
2017 · Ulrich Eckhard, Hina Bandukwala, et al. · Nature Communications · 60
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Structures of Rat Cytosolic PEPCK: Insight into the Mechanism of Phosphorylation and Decarboxylation of Oxaloacetic Acid,
2007 · Sarah M. Sullivan, Todd Holyoak · Biochemistry · 54
Malonate: a versatile cryoprotectant and stabilizing solution for salt-grown macromolecular crystals
2003 · Todd Holyoak, Timothy D. Fenn, et al. · Acta Crystallographica Section D Biological Crystallography · 50
Structural Insights into the Mechanism of Phosphoenolpyruvate Carboxykinase Catalysis
2009 · Gerald M. Carlson, Todd Holyoak · Journal of Biological Chemistry · 47
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Structural Basis for Differences in Substrate Selectivity in Kex2 and Furin Protein Convertases,
2004 · Todd Holyoak, Charles A. Kettner, et al. · Biochemistry · 46
The Ω-Loop Lid Domain of Phosphoenolpyruvate Carboxykinase Is Essential for Catalytic Function
2012 · Troy A. Johnson, Todd Holyoak · Biochemistry · 40
Energetic Coupling between an Oxidizable Cysteine and the Phosphorylatable N-Terminus of Human Liver Pyruvate Kinase
2012 · Todd Holyoak, Bing Zhang, et al. · Biochemistry · 37
Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition
2008 · Rose Mary Stiffin, Sarah M. Sullivan, et al. · Biochemistry · 36
Inhibition and Allosteric Regulation of Monomeric Phosphoenolpyruvate Carboxykinase by 3-Mercaptopicolinic Acid
2015 · Marc D. Balan, Matthew J. Mcleod, et al. · Biochemistry · 32
Energetic Coupling between an Oxidizable Cysteine and the Phosphorylatable N-Terminus of Human Liver Pyruvate Kinase
2013 · Aron Fenton, Todd Holyoak, et al. · Biophysical Journal · 32
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Increasing the Conformational Entropy of the Ω-Loop Lid Domain in Phosphoenolpyruvate Carboxykinase Impairs Catalysis and Decreases Catalytic Fidelity,
2010 · Troy A. Johnson, Todd Holyoak · Biochemistry · 32
Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease
2020 · Zhiming Wang, Jeremy Rahkola, et al. · Nature Communications · 30
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Utilization of Substrate Intrinsic Binding Energy for Conformational Change and Catalytic Function in Phosphoenolpyruvate Carboxykinase
2015 · Troy A. Johnson, Matthew J. Mcleod, et al. · Biochemistry · 27
A structural perspective on the temperature dependent activity of enzymes
2025 · Matthew J. McLeod, Sarah A.E. Barwell, et al. · Structure · 26
A Putative Alzheimer's Disease Risk Allele in PCK1 Influences Brain Atrophy in Multiple Sclerosis
2010 · Zongqi Xia, Lori B. Chibnik, et al. · PLoS ONE · 24
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Effect of a Y265F Mutant on the Transamination-Based Cycloserine Inactivation of Alanine Racemase,
2005 · Timothy D. Fenn, Todd Holyoak, et al. · Biochemistry · 24
Differential P 1 arginine and lysine recognition in the prototypical proprotein convertase Kex2
2007 · Joshua L. Wheatley, Todd Holyoak · Proceedings of the National Academy of Sciences · 23
Works count: 142
Citation count: 1,677
H-index: 24
I10-index: 35
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