Author

Robert J. Sims

Observed names: R J Sims III, R. J. Sims, R. Sims, R. Sims III, Robert J Sims, Robert J Sims III, Robert J Sims Iii, Robert J. Sims III, Robert J. Sims Iii, Robert Sims, Robert J. Sims, Sims RJ, Sims Robert J., Sims, Robert Joseph

Observed institutions: Rutgers, The State University of New Jersey, Howard Hughes Medical Institute, WuXi AppTec (China), NYU Langone Health, Constellation Pharmaceuticals (United States), University of Medicine and Dentistry of New Jersey, New York University, The University of Texas at Austin

OpenAlex ID: A5077841984

Targeting MYC dependence in cancer by inhibiting BET bromodomains

2011 · Jennifer A. Mertz, Andrew R. Conery, et al. · Proceedings of the National Academy of Sciences · 1,118

Elongation by RNA polymerase II: the short and long of it

2004 · Robert J. Sims, Rimma Belotserkovskaya, et al. · Genes & Development · 709

PDF

Histone lysine methylation: a signature for chromatin function

2003 · Robert J. Sims, Kenichi Nishioka, et al. · Trends in Genetics · 691

Recognition of Trimethylated Histone H3 Lysine 4 Facilitates the Recruitment of Transcription Postinitiation Factors and Pre-mRNA Splicing

2007 · Robert J. Sims, Scott Millhouse, et al. · Molecular Cell · 581

PDF

Bromodomains: a new target class for drug development

2019 · Andrea G. Cochran, Andrew R. Conery, et al. · Nature Reviews Drug Discovery · 440

Human but Not Yeast CHD1 Binds Directly and Selectively to Histone H3 Methylated at Lysine 4 via Its Tandem Chromodomains

2005 · Robert J. Sims, Chi-Fu Chen, et al. · Journal of Biological Chemistry · 423

BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain

2012 · Ballachanda N. Devaiah, Brian A. Lewis, et al. · Proceedings of the National Academy of Sciences · 379

PDF

L3MBTL1, a Histone-Methylation-Dependent Chromatin Lock

2007 · Patrick Trojer, Guohong Li, et al. · Cell · 343

Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

2002 · Paul D. Gottlieb, Stephanie A. Pierce, et al. · Nature Genetics · 320

Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex

2006 · Mark A Brown, Robert J Sims, et al. · Molecular Cancer · 314

PDF

Is there a code embedded in proteins that is based on post-translational modifications?

2008 · Robert J. Sims, Danny Reinberg · Nature Reviews Molecular Cell Biology · 289

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

2007 · Ashley E Sims, Elizabeth Spiteri, et al. · Nature Structural & Molecular Biology · 275

Histone H3 Lys 4 methylation: caught in a bind?

2006 · Robert J. Sims, Danny Reinberg · Genes & Development · 239

de FACTo Nucleosome Dynamics

2006 · Danny Reinberg, Robert J. Sims · Journal of Biological Chemistry · 238

The C-Terminal Domain of RNA Polymerase II Is Modified by Site-Specific Methylation

2011 · Robert J. Sims, Luis Alejandro Rojas, et al. · Science · 228

Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials

2016 · Brian K. Albrecht, Victor S. Gehling, et al. · Journal of Medicinal Chemistry · 218

Recent highlights of RNA-polymerase-II-mediated transcription

2004 · Robert J Sims, Subhrangsu S Mandal, et al. · Current Opinion in Cell Biology · 194

ATR-Mediated Phosphorylation of FANCI Regulates Dormant Origin Firing in Response to Replication Stress

2015 · Yu-Hung Chen, Mathew J.K. Jones, et al. · Molecular Cell · 160

PDF

Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma

2016 · Andrew R Conery, Richard C Centore, et al. · eLife · 125

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

2016 · Alexander M. Taylor, Alexandre Côté, et al. · ACS Medicinal Chemistry Letters · 119

Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors

2013 · Victor S. Gehling, Michael C. Hewitt, et al. · ACS Medicinal Chemistry Letters · 105

m-Bop, a Repressor Protein Essential for Cardiogenesis, Interacts with skNAC, a Heart- and Muscle-specific Transcription Factor

2002 · Robert J. Sims, Elizabeth K. Weihe, et al. · Journal of Biological Chemistry · 98

Targeting epigenetic regulators for cancer therapy

2014 · Susan Wee, Dash Dhanak, et al. · Annals of the New York Academy of Sciences · 81

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition

2016 · Srimoyee Ghosh, Alexander Taylor, et al. · Journal of Biological Chemistry · 80

PDF

Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor

2020 · Jonathan E. Wilson, Gaurav Patel, et al. · ACS Medicinal Chemistry Letters · 78

Works count: 102

Citation count: 8,573

H-index: 33

I10-index: 46