Get started
Author

Ian K. Gurrell

Observed names: Gurrell, Ian, I. K. Gurrell, Ian Gurrell, Ian K Gurrell
OpenAlex ID: A5078769216
Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
2020 · M. Catarina Silva, Ghata A. Nandi, et al. · Nature Communications · 156
PDF
Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo
2019 · Darren J. Schofield, Lorraine Irving, et al. · Neurobiology of Disease · 119
Application of PBPK modelling in drug discovery and development at Pfizer
2011 · Hannah M Jones, Maurice Dickins, et al. · Xenobiotica · 96
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7
2017 · Nigel. A. Swain, Dave Batchelor, et al. · Journal of Medicinal Chemistry · 87
Antibody-oligonucleotide conjugate achieves CNS delivery in animal models for spinal muscular atrophy
2022 · Suzan M. Hammond, Frank Abendroth, et al. · JCI Insight · 66
PDF
Enhanced delivery of IL-1 receptor antagonist to the central nervous system as a novel anti–transferrin receptor-IL-1RA fusion reverses neuropathic mechanical hypersensitivity
2016 · Carl I. Webster, Jon Hatcher, et al. · Pain · 63
A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model
2018 · George Thom, Mei-Mei Tian, et al. · Journal of Cerebral Blood Flow & Metabolism · 47
Isolation of blood-brain barrier-crossing antibodies from a phage display library by competitive elution and their ability to penetrate the central nervous system
2017 · George Thom, Jon Hatcher, et al. · mAbs · 40
PDF
Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice
2023 · Rebecca Jarvis, Shu Fun Josephine Ng, et al. · Cell Reports Medicine · 39
Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels
2016 · Hannah M. Jones, Richard P. Butt, et al. · Clinical Pharmacokinetics · 37
Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity
2018 · Patrik Johansson, Karin Kaspersson, et al. · Journal of Medicinal Chemistry · 33
Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine
2020 · Caroline M Kopruszinski, Peter Thornton, et al. · Cephalalgia · 32
Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine
2024 · Caroline M Kopruszinski, John E Linley, et al. · Brain · 14
Case studies addressing human pharmacokinetic uncertainty using a combination of pharmacokinetic simulation and alternative first in human paradigms
2011 · Anthony Harrison, Iain Gardner, et al. · Xenobiotica · 13
N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors
2008 · Florian Wakenhut, Paul V. Fish, et al. · Bioorganic & Medicinal Chemistry Letters · 12
Translational PK/PD: a retrospective analysis of performance and impact from a drug portfolio
2025 · Rasmus Jansson-Löfmark, Markus Fridén, et al. · Drug Discovery Today · 10
Systemic antibody-oligonucleotide delivery to the central nervous system ameliorates mouse models of spinal muscular atrophy
2021 · Suzan M Hammond, Frank Abendroth, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 10
PDF
11. Orexin-1 Receptor Antagonists as Novel Smoking Cessation Agents
2018 · Paul Kenny, Theodore Kamenecka, et al. · Biological Psychiatry · 1
Effect of D158A mutation in human pancreatic GLK on regulation by liver GKRP and fructose phosphates
2000 · K. J. Brocklehurst, H. L. Vertigan, et al. · Biochemical Society Transactions
Works count: 23
Citation count: 875
H-index: 13
I10-index: 17
Year
Topic
Type