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Iain R. Tough

Observed names: I R Tough, I. R. Tough, I.R Tough, I.R. Tough, IAIN R. TOUGH, IR Tough, Iain R Tough, Iain Tough, Iain R. Tough, Tough, Iain R, Tough, Iain R.
ORCID: 0000-0002-4829-9369
Observed ORCID: 0000-0002-4829-9369
OpenAlex ID: A5079964496
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons
2015 · Masoud Ghamari-Langroudi, Gregory J. Digby, et al. · Nature · 190
The Melanocortin-4 Receptor Is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-like Peptide 1 In Vivo
2014 · Brandon L. Panaro, Iain R. Tough, et al. · Cell Metabolism · 179
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Peptide YY Is Critical for Acylethanolamine Receptor Gpr119-Induced Activation of Gastrointestinal Mucosal Responses
2010 · Helen M. Cox, Iain R. Tough, et al. · Cell Metabolism · 116
Endogenous peptide YY and neuropeptide Y inhibit colonic ion transport, contractility and transit differentially via Y 1 and Y 2 receptors
2011 · IR Tough, S Forbes, et al. · British Journal of Pharmacology · 74
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Neuropeptide Y, Y 1 , Y 2 and Y 4 receptors mediate Y agonist responses in isolated human colon mucosa
2002 · Helen M Cox, Iain R Tough · British Journal of Pharmacology · 66
Properties of cholinergic and non‐cholinergic submucosal neurons along the mouse colon
2013 · Jaime Pei Pei Foong, Iain R. Tough, et al. · The Journal of Physiology · 63
Functional consequences of neuropeptide Y Y2 receptor knockout and Y2 antagonism in mouse and human colonic tissues
2003 · Niall P Hyland, Frida Sjöberg, et al. · British Journal of Pharmacology · 53
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L ‐arginine promotes gut hormone release and reduces food intake in rodents
2016 · A. Alamshah, A. K. McGavigan, et al. · Diabetes Obesity and Metabolism · 47
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Multiple Y receptors mediate pancreatic polypeptide responses in mouse colon mucosa
2001 · Helen M. Cox, Emma L. Pollock, et al. · Peptides · 44
The extracellular matrix glycoprotein tenascin‐X regulates peripheral sensory and motor neurones
2018 · Rubina Aktar, Madusha Peiris, et al. · The Journal of Physiology · 43
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Role of the C Terminus in Neuropeptide Y Y Receptor Desensitization and Internalization
2004 · Nicholas D. Holliday, Chi-Wing Lam, et al. · Molecular Pharmacology · 41
Y4 Receptors Mediate the Inhibitory Responses of Pancreatic Polypeptide in Human and Mouse Colon Mucosa
2006 · Iain R. Tough, Nicholas D. Holliday, et al. · Journal of Pharmacology and Experimental Therapeutics · 40
Endogenous PYY and GLP ‐1 mediate l ‐glutamine responses in intestinal mucosa
2013 · S Joshi, I R Tough, et al. · British Journal of Pharmacology · 38
Signaling of free fatty acid receptors 2 and 3 differs in colonic mucosa following selective agonism or coagonism by luminal propionate
2018 · Iain R. Tough, Sarah Forbes, et al. · Neurogastroenterology & Motility · 37
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Selective inhibition of neuropeptide Y Y1 receptors by BIBP3226 in rat and human epithelial preparations
1996 · Iain R. Tough, Helen M. Cox · European Journal of Pharmacology · 32
Calcitonin gene‐related peptide receptors in human gastrointestinal epithelia
1994 · H.M. Cox, I.R. Tough · British Journal of Pharmacology · 30
Functional characterization of receptors with affinity for PYY, NPY, [Leu31, Pro34]NPY and PP in a human colonic epithelial cell line
1995 · H.M. Cox, I.R Tough · British Journal of Pharmacology · 29
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Dual and selective antagonism of neurokinin NK1 and NK2 receptor-mediated responses in human colon mucosa
2003 · Iain R. Tough, Christine A. Lewis, et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 27
Pharmacological characterisation of neurokinin receptors mediating anion secretion in rat descending colon mucosa
1993 · Helen M. Cox, Iain R. Tough, et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 26
Highly Selective Y4 Receptor Antagonist Binds in an Allosteric Binding Pocket
2021 · Corinna Schüß, Oanh Vu, et al. · Journal of Medicinal Chemistry · 25
Growth of the maternal intestine during reproduction
2025 · Tomotsune Ameku, Anna Laddach, et al. · Cell · 24
Bidirectional GPR119 Agonism Requires Peptide YY and Glucose for Activity in Mouse and Human Colon Mucosa
2018 · Iain R Tough, Sarah Forbes, et al. · Endocrinology · 23
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Gastrointestinal hormonal responses on GPR119 activation in lean and diseased rodent models of type 2 diabetes
2014 · S Patel, O J Mace, et al. · International Journal of Obesity · 23
Synthetic G protein‐coupled bile acid receptor agonists and bile acids act via basolateral receptors in ileal and colonic mucosa
2020 · Iain R. Tough, Thue W. Schwartz, et al. · Neurogastroenterology & Motility · 22
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Agonism of free fatty acid receptors 1 and 4 generates peptide YY‐mediated inhibitory responses in mouse colon
2017 · Runisha Moodaley, David M Smith, et al. · British Journal of Pharmacology · 22
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Works count: 56
Citation count: 1,491
H-index: 23
I10-index: 36
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