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Thomas K. H. Chang

Observed names: Chang, Thomas Kwok Hung, T Chang, T K Chang, T K H Chang, T. Chang, T. K. H. Chang, T.K.H. Chang, Thomas Chang, Thomas H. Chang, Thomas K Chang, Thomas K H Chang, Thomas K. H Chang, Thomas K.H Chang, Thomas K.H. Chang, Thomas KH Chang
Observed institutions: Boston University, National Institutes of Health, Albert Einstein College of Medicine, Harvard University, University of British Columbia, University of Calgary, National Institute of Environmental Health Sciences, Dana-Farber Cancer Institute
ORCID: 0000-0003-2167-5165
Observed ORCID: 0000-0003-2167-5165
OpenAlex ID: A5080120427
Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes.
1993 · T K Chang, G F Weber, et al. · PubMed · 548
Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: Regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes
1995 · Arleen B. Rifkind, Charis Lee, et al. · Archives of Biochemistry and Biophysics · 251
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Evaluation of Triacetyloleandomycin, α-Nasymphthoflavone and Diethyldithiocarbamate as Selective Chemical Probes for Inhibition of Human Cytochromes P450
1994 · T.K.H. Chang, F.J. Gonzalez, et al. · Archives of Biochemistry and Biophysics · 251
Human cytochrome P4502B6: interindividual hepatic expression, substrate specificity, and role in procarcinogen activation.
1997 · E L Code, C L Crespi, et al. · PubMed · 245
Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines.
1997 · T K Chang, L Yu, et al. · PubMed · 195
Contribution of CYP2C9, CYP2A6, and CYP2B6 to Valproic Acid Metabolism in Hepatic Microsomes from Individuals with the CYP2C9*1/*1 Genotype
2006 · T. K. L. Kiang, P. C. Ho, et al. · Toxicological Sciences · 160
Experimental Tumor Therapy in Mice Using the Cyclophosphamide-Activating Cytochrome P450 2B1 Gene
1994 · Ming X. Wei, Takashi Tamiya, et al. · Human Gene Therapy · 154
Oxidative Stress as a Mechanism of Valproic Acid-Associated Hepatotoxicity
2006 · Thomas K. H. Chang, Frank S. Abbott · Drug Metabolism Reviews · 150
Valproic Acid I: Time Course of Lipid Peroxidation Biomarkers, Liver Toxicity, and Valproic Acid Metabolite Levels in Rats
2005 · Vincent Tong, Xiao Wei Teng, et al. · Toxicological Sciences · 149
Valproic Acid II: Effects on Oxidative Stress, Mitochondrial Membrane Potential, and Cytotoxicity in Glutathione-Depleted Rat Hepatocytes
2005 · Vincent Tong, Xiao Wei Teng, et al. · Toxicological Sciences · 147
Differential Inhibition and Inactivation of Human CYP1 Enzymes bytrans-Resveratrol: Evidence for Mechanism-Based Inactivation of CYP1A2
2001 · Thomas K.H. Chang, Jie Chen, et al. · Journal of Pharmacology and Experimental Therapeutics · 144
Synthetic Drugs and Natural Products as Modulators of Constitutive Androstane Receptor (Car) and Pregnane X Receptor (PXR)
2006 · Thomas K. H. Chang, David J. Waxman · Drug Metabolism Reviews · 143
Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359allele as low-Kmcatalysts of cyclophosphamide and ifosfamide activation
1997 · Thomas K.H Chang, Li Yu, et al. · Pharmacogenetics · 132
Pharmacogenetics
2001 · Mary H.H. Ensom, Thomas K.H. Chang, et al. · Clinical Pharmacokinetics · 119
Activation of Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) by Herbal Medicines
2009 · Thomas K. H. Chang · The AAPS Journal · 107
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Constitutive Androstane Receptor and Pregnane X Receptor Gene Expression in Human Liver: Interindividual Variability and Correlation with CYP2B6 mRNA Levels
2003 · Thomas K.H. Chang, Stelvio M. Bandiera, et al. · Drug Metabolism and Disposition · 101
Influence of CYP2C9 genotypes on the formation of a hepatotoxic metabolite of valproic acid in human liver microsomes
2003 · P C Ho, F S Abbott, et al. · The Pharmacogenomics Journal · 99
Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation
2016 · Aditya Garg, Angela Zhao, et al. · Journal of Pharmacology and Experimental Therapeutics · 82
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Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: Identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1
2005 · Thomas K.H. Chang, Jie Chen, et al. · Toxicology and Applied Pharmacology · 80
Hormonal Regulation of Liver Cytochrome P450 Enzymes
2015 · David J. Waxman, Thomas K. H. Chang · Springer eBooks · 79
Real-Time Polymerase Chain Reaction Analysis of CYP1B1 Gene Expression in Human Liver
2003 · T. K. H. Chang · Toxicological Sciences · 78
In Vitro Effect of Standardized Ginseng Extracts and Individual Ginsenosides on the Catalytic Activity of Human CYP1A1, CYP1A2, and CYP1B1
2002 · Thomas K.H. Chang, Jie Chen, et al. · Drug Metabolism and Disposition · 75
Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1
2000 · Thomas K.H. Chang, Wendy B.K. Lee, et al. · Canadian Journal of Physiology and Pharmacology · 73
Dose-dependent protection of cardiac function by propofol during ischemia and early reperfusion in rats: effects on 15-F 2t -isoprostane formation
2003 · Zhengyuan Xia, David V Godin, et al. · Canadian Journal of Physiology and Pharmacology · 71
Comparison of polychlorinated dibenzodioxin levels with hepatic mixed‐function oxidase induction in great blue herons
1990 · G. D. Bellward, R. J. Norstrom, et al. · Journal of Toxicology and Environmental Health · 71
Works count: 158
Citation count: 5,810
H-index: 40
I10-index: 97
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