Get started
Author

Alexis Digman

ORCID: 0000-0002-9308-464X
Observed ORCID: 0000-0002-9308-464X
OpenAlex ID: A5080416312
Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms
2020 · Ivan Nyarko-Danquah, Edward Pajarillo, et al. · Molecules · 120
PDF
Mechanisms of manganese-induced neurotoxicity and the pursuit of neurotherapeutic strategies
2022 · Edward Pajarillo, Ivan Nyarko-Danquah, et al. · Frontiers in Pharmacology · 65
PDF
The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction
2023 · Edward Pajarillo, Sanghoon Kim, et al. · Journal of Biological Chemistry · 56
PDF
Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity
2021 · Edward Pajarillo, Alexis Digman, et al. · Journal of Biological Chemistry · 41
Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation
2022 · Edward Pajarillo, Ivan Nyarko‐Danquah, et al. · Glia · 24
Manganese-induced reactive oxygen species activate IκB kinase to upregulate YY1 and impair glutamate transporter EAAT2 function in human astrocytes in vitro
2021 · Asha Rizor, Edward Pajarillo, et al. · NeuroToxicology · 21
Deletion of RE1‐silencing transcription factor in striatal astrocytes exacerbates manganese‐induced neurotoxicity in mice
2022 · Edward Pajarillo, Mark Demayo, et al. · Glia · 18
Dopaminergic REST/NRSF is protective against manganese-induced neurotoxicity in mice
2024 · Edward Pajarillo, Sanghoon Kim, et al. · Journal of Biological Chemistry · 16
Tamoxifen induces protection against manganese toxicity by REST upregulation via the ER-α/Wnt/β-catenin pathway in neuronal cells
2025 · Alexis Digman, Edward Pajarillo, et al. · Journal of Biological Chemistry · 7
Role of dopaminergic RE1-silencing transcription factor (REST) in manganese-induced behavioral deficits and dysregulating dopaminergic and serotonergic neurotransmission in mice
2025 · Sanghoon Kim, Edward Pajarillo, et al. · NeuroToxicology · 7
PDF
Microglial Sp1 induced LRRK2 upregulation in response to manganese exposure, and 17β-estradiol afforded protection against this manganese toxicity
2024 · Ivan Nyarko-Danquah, Edward Pajarillo, et al. · NeuroToxicology · 5
PDF
CAD (Cath. a-Differentiated) Cells Produce Dopamine along with Dopamine-Synthesizing Enzymes
2025 · Sanghoon Kim, Edward Pajarillo, et al. · Neurochemical Research · 3
PDF
Dopaminergic REST is implicated in the tamoxifen-induced neuroprotection against manganese toxicity in female mice
2025 · Edward Pajarillo, Alexis Digman, et al. · Frontiers in Pharmacology · 2
PDF
Tamoxifen attenuates manganese-induced dysregulation of neuronal REST via the genomic ER-α mechanism
2025 · Alexis Digman, Edward Pajarillo, et al. · Frontiers in Molecular Neuroscience · 1
PDF
Tamoxifen induces partial neuroprotection against manganese toxicity in the dopaminergic REST-deleted male mice
2025 · Alexis Digman, Edward Pajarillo, et al. · NeuroToxicology
PDF
Role of Glial Cells in Neurodegenerative Diseases and Metals-Induced Neurotoxicity
2025 · Edward Pajarillo, Ivan Nyarko-Danquah, et al. · Elsevier eBooks
Works count: 16
Citation count: 386
H-index: 8
I10-index: 8
Year
Topic
Type