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Author

Christian Zierhut

Observed names: C. Zierhut, Zierhut, Christian
Observed institutions: University of Vienna, Royal Marsden NHS Foundation Trust, Institute of Cancer Research, Breast Cancer Now, Cancer Research UK, Max Perutz Labs, Institute of Cancer Research, Rockefeller University
ORCID: 0000-0003-3501-603X
Observed ORCID: 0000-0003-3501-603X
OpenAlex ID: A5081345913
Survivin Reads Phosphorylated Histone H3 Threonine 3 to Activate the Mitotic Kinase Aurora B
2010 · Alexander E. Kelly, Cristina Ghenoiu, et al. · Science · 474
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
2019 · Christian Zierhut, Norihiro Yamaguchi, et al. · Cell · 406
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Structural basis for the inhibition of cGAS by nucleosomes
2020 · Tomoya Kujirai, Christian Zierhut, et al. · Science · 242
Break dosage, cell cycle stage and DNA replication influence DNA double strand break response
2008 · Christian Zierhut, John F X Diffley · The EMBO Journal · 234
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VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair
2016 · Johannes van den Boom, Markus Wolf, et al. · Molecular Cell · 112
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Nucleosomal regulation of chromatin composition and nuclear assembly revealed by histone depletion
2014 · Christian Zierhut, Christopher Jenness, et al. · Nature Structural & Molecular Biology · 100
Regulation and Consequences of cGAS Activation by Self-DNA
2020 · Christian Zierhut, Hironori Funabiki · Trends in Cell Biology · 92
Mnd1 Is Required for Meiotic Interhomolog Repair
2004 · Christian Zierhut, Marc Berlinger, et al. · Current Biology · 90
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Vaccinia E5 is a major inhibitor of the DNA sensor cGAS
2023 · Ning Yang, Yi Wang, et al. · Nature Communications · 50
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Nucleosome functions in spindle assembly and nuclear envelope formation
2015 · Christian Zierhut, Hironori Funabiki · BioEssays · 25
Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair
2023 · Christian Zierhut · DNA repair · 17
A microscopy reporter for cGAMP reveals rare cGAS activation following DNA damage, and a lack of correlation with micronuclear cGAS enrichment
2024 · Vivianne Lebrec, Negar Afshar, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 12
Effects of oncolytic immunotherapy with RP1 (vusolimogene oderparepvec) on immune cells mediate responsiveness to anti-PD-1 via STING-mediated interferon signaling
2026 · Victoria Roulstone, Joan Kyula, et al. · Journal for ImmunoTherapy of Cancer · 5
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Nucleosome-Dependent Pathways That Control Mitotic Progression
2017 · Hironori Funabiki, Christopher Jenness, et al. · Cold Spring Harbor Symposia on Quantitative Biology · 5
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Mitotic errors as triggers of cell death and inflammation
2026 · Dario Rizzotto, Christian Zierhut, et al. · Nature Cell Biology · 3
A versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability
2026 · Vivianne Lebrec, Alexandra Kanellou, et al. · Nature Cell Biology · 2
p53 and Innate Immune Signaling in Development and Cancer: Insights from a Hematologic Model of Genome Instability
2023 · Christian Zierhut · Cancer Research · 2
Measuring cGAMP production in living single cells using a dedicated FRET reporter v1
2026 · Vivianne Lebrec, Christian Zierhut · 1
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Images and code for Lebrec et al. Nature Cell Biology 2026
2026 · Lebrec, Vivianne, Zierhut, Christian · Zenodo (CERN European Organization for Nuclear Research) · 1
Mitotic lethality prevents inflammation
2025 · Christian Zierhut, Andreas Villunger · Nature Cell Biology · 1
TMEM33 deletion potentiates anti-tumor CD8 + T cell immunity
2026 · Matthew T Jackson, Tianming Zhao, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Radiation-dependent Nucleic Acid Sensing, and Its Possible Impact on Radiotherapy
2025 · Robert J. Pickering, Christian Zierhut · The Cancer Journal
DNA damage and chromosomal instability
2024 · Christian Zierhut · Methods in cell biology
Human cGAS-nucleosome complex
2020 · T. Kujirai, C. Zierhut, et al. · Worldwide Protein Data Bank
The involvement of single-stranded DNA, replication protein A, and the DNA double-strand break dose in the damage checkpoint of Saccharomyces cerevisiae
2007 · Christian Zierhut · UCL Discovery (University College London)
Works count: 25
Citation count: 1,874
H-index: 12
I10-index: 12
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