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Rune Kleppe

Observed names: Kleppe, Rune, R Kleppe, R. Kleppe, RUNE KLEPPE
Observed institutions: University of Leicester, University of Dundee, Masaryk University, Haukeland University Hospital, Central European Institute of Technology – Masaryk University, University of Bergen
ORCID: 0000-0002-6086-755X
Observed ORCID: 0000-0002-6086-755X
OpenAlex ID: A5081698578
The 14-3-3 proteins in regulation of cellular metabolism
2011 · Rune Kleppe, Aurora Martinez, et al. · Seminars in Cell and Developmental Biology · 152
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The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models
2024 · Hayley J. MacDonald, Rune Kleppe, et al. · Frontiers in Psychiatry · 129
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Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation
2022 · María Teresa Bueno-Carrasco, Jorge Cuéllar, et al. · Nature Communications · 111
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Regulation of tyrosine hydroxylase by stress‐activated protein kinases
2002 · Karen Toska, Rune Kleppe, et al. · Journal of Neurochemistry · 98
Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease
2016 · Kai Waløen, Rune Kleppe, et al. · Expert Opinion on Therapeutic Targets · 89
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Interaction of phosphorylated tyrosine hydroxylase with 14‐3‐3 proteins: evidence for a phosphoserine 40‐dependent association
2001 · Rune Kleppe, Karen Toska, et al. · Journal of Neurochemistry · 70
Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding
2008 · Ingeborg Winge, Jeffrey A. Mckinney, et al. · Biochemical Journal · 68
Does Isoform Diversity Explain Functional Differences in the 14-3-3Protein Family?
2006 · E. Kjarland, T. Keen, et al. · Current Pharmaceutical Biotechnology · 62
ADHD symptoms in neurometabolic diseases: Underlying mechanisms and clinical implications
2021 · Selina Cannon Homaei, Helene Barone, et al. · Neuroscience & Biobehavioral Reviews · 61
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Functional Studies of Tyrosine Hydroxylase Missense Variants Reveal Distinct Patterns of Molecular Defects in Dopa ‐Responsive Dystonia
2014 · Agnete Fossbakk, Rune Kleppe, et al. · Human Mutation · 55
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GADL1 is a multifunctional decarboxylase with tissue-specific roles in β-alanine and carnosine production
2020 · Elaheh Mahootchi, Selina Cannon Homaei, et al. · Science Advances · 48
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Three-way Interaction between 14-3-3 Proteins, the N-terminal Region of Tyrosine Hydroxylase, and Negatively Charged Membranes
2009 · Øyvind Halskau, Ming Ying, et al. · Journal of Biological Chemistry · 44
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Nostocyclopeptide-M1: A Potent, Nontoxic Inhibitor of the Hepatocyte Drug Transporters OATP1B3 and OATP1B1
2011 · Lars Herfindal, Lene Myhren, et al. · Molecular Pharmaceutics · 40
Increased microvascular permeability in mice lacking Epac1 (Rapgef3)
2016 · R. K. Kopperud, C. Brekke Rygh, et al. · Acta Physiologica · 39
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Exome chip analyses in adult attention deficit hyperactivity disorder
2016 · T Zayats, K K Jacobsen, et al. · Translational Psychiatry · 36
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Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription
2011 · S Huseby, G Gausdal, et al. · Cell Death and Disease · 35
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Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression
2015 · Ingeborg Winge, Knut Teigen, et al. · Neurochemistry International · 34
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Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis
2013 · G Gausdal, A Wergeland, et al. · Cell Death and Disease · 34
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Tyrosinemia Type 1 and symptoms of ADHD: Biochemical mechanisms and implications for treatment and prognosis
2019 · Helene Barone, Yngve T. Bliksrud, et al. · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · 32
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In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins
2017 · Yasaman Pakdaman, Monica Sanchez-Guixé, et al. · Bioscience Reports · 31
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Urea-induced Denaturation of Human Phenylalanine Hydroxylase
1999 · Rune Kleppe, Kathrin Uhlemann, et al. · Journal of Biological Chemistry · 30
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Personalized Medicine to Improve Treatment of Dopa-Responsive Dystonia—A Focus on Tyrosine Hydroxylase Deficiency
2021 · Gyrid Nygaard, Peter D. Szigetvari, et al. · Journal of Personalized Medicine · 29
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Epistatic and gene wide effects in YWHA and aromatic amino hydroxylase genes across ADHD and other common neuropsychiatric disorders: Association with YWHAE
2015 · Kaya K. Jacobsen, Rune Kleppe, et al. · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · 28
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Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules
2017 · Ana Jorge-Finnigan, Rune Kleppe, et al. · Journal of Biological Chemistry · 26
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The effects of phenylalanine and tyrosine levels on dopamine production in rat PC12 cells. Implications for treatment of phenylketonuria, tyrosinemia type 1 and comorbid neurodevelopmental disorders
2023 · Peter D. Szigetvari, Sudarshan Patil, et al. · Neurochemistry International · 23
Works count: 53
Citation count: 1,646
H-index: 24
I10-index: 35
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