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James Thomas Topham

Observed names: J. T. Topham, J. Topham, James T Topham, James T. Topham, James T. Topham (3385211), James Topham, Topham, James T.
Observed institutions: BC Cancer Agency, University of British Columbia, Hospital for Sick Children, Vancouver General Hospital, Canada's Michael Smith Genome Sciences Centre, Pancreas Centre (Canada)
ORCID: 0009-0001-6601-8807
Observed ORCID: 0009-0001-6601-8807
OpenAlex ID: A5081831776
Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution
2020 · Michelle Chan-Seng-Yue, Jaeseung C. Kim, et al. · Nature Genetics · 666
Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia
2019 · Paul C. McDonald, Shawn C. Chafe, et al. · Gastroenterology · 221
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Altered Gene Expression along the Glycolysis–Cholesterol Synthesis Axis Is Associated with Outcome in Pancreatic Cancer
2019 · Joanna M. Karasinska, James T. Topham, et al. · Clinical Cancer Research · 211
The CCTG PA.7 phase II trial of gemcitabine and nab-paclitaxel with or without durvalumab and tremelimumab as initial therapy in metastatic pancreatic ductal adenocarcinoma
2022 · Daniel J. Renouf, Jonathan M. Loree, et al. · Nature Communications · 156
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NRG1 Gene Fusions Are Recurrent, Clinically Actionable Gene Rearrangements in KRAS Wild-Type Pancreatic Ductal Adenocarcinoma
2019 · Martin R. Jones, Laura M. Williamson, et al. · Clinical Cancer Research · 156
Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration
2019 · Hye-Jung E. Chun, Pascal D. Johann, et al. · Cell Reports · 118
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Genome and Transcriptome Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Solid Tumors
2020 · Alexandra Pender, Emma Titmuss, et al. · Clinical Cancer Research · 90
Clinical and genomic characterisation of mismatch repair deficient pancreatic adenocarcinoma
2020 · Robert C Grant, Robert Denroche, et al. · Gut · 71
Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti–Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer
2022 · James T. Topham, Chris J. O'Callaghan, et al. · Journal of Clinical Oncology · 69
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Subtype-Discordant Pancreatic Ductal Adenocarcinoma Tumors Show Intermediate Clinical and Molecular Characteristics
2020 · James T. Topham, Joanna M. Karasinska, et al. · Clinical Cancer Research · 54
MicroRNA Expression-Based Model Indicates Event-Free Survival in Pediatric Acute Myeloid Leukemia
2017 · Emilia L. Lim, Diane L. Trinh, et al. · Journal of Clinical Oncology · 54
Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma
2022 · James T. Topham, Erica S. Tsang, et al. · Nature Communications · 41
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Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?
2020 · Erica S. Tsang, James T. Topham, et al. · Clinical Cancer Research · 36
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Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration
2023 · Erica S. Tsang, Veronika Csizmok, et al. · npj Precision Oncology · 29
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Endogenous Retrovirus Transcript Levels Are Associated with Immunogenic Signatures in Multiple Metastatic Cancer Types
2020 · James T. Topham, Emma Titmuss, et al. · Molecular Cancer Therapeutics · 24
Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles
2024 · Hassan A. Ali, Joanna M. Karasinska, et al. · Cancer & Metabolism · 23
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Uncovering Clinically Relevant Gene Fusions with Integrated Genomic and Transcriptomic Profiling of Metastatic Cancers
2020 · Erica S. Tsang, Cameron J. Grisdale, et al. · Clinical Cancer Research · 23
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Feasibility and value of genomic profiling in cancer of unknown primary: real-world evidence from prospective profiling study
2023 · Ryan W Huey, Aakash Tushar Shah, et al. · JNCI Journal of the National Cancer Institute · 22
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Plasma versus Tissue Tumor Mutational Burden as Biomarkers of Durvalumab plus Tremelimumab Response in Patients with Metastatic Colorectal Cancer in the CO.26 Trial
2024 · Jonathan M. Loree, Emma Titmuss, et al. · Clinical Cancer Research · 20
Author Correction: Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution
2020 · Michelle Chan-Seng-Yue, Jaeseung C. Kim, et al. · Nature Genetics · 20
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Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis
2025 · Paul C. McDonald, James T. Topham, et al. · Communications Biology · 16
A Deep Learning Approach for the Identification of the Molecular Subtypes of Pancreatic Ductal Adenocarcinoma Based on Whole Slide Pathology Images
2024 · Pouya Ahmadvand, Hossein Farahani, et al. · American Journal Of Pathology · 15
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Circulating tumor DNA: toward evolving the clinical paradigm of pancreatic ductal adenocarcinoma
2023 · James T. Topham, Daniel J. Renouf, et al. · Therapeutic Advances in Medical Oncology · 15
Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions
2024 · Adam R. Wolfe, Tiantian Cui, et al. · Science Advances · 14
Tumor infiltrating neutrophils and gland formation predict overall survival and molecular subgroups in pancreatic ductal adenocarcinoma
2020 · Julia R. Naso, James T. Topham, et al. · Cancer Medicine · 13
Works count: 165
Citation count: 2,286
H-index: 20
I10-index: 27
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