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Natalie A. Dales

Observed names: Dales, Natalie A., N Dales, N. A. DALES, N. Dales, N.A. Dales, Natalie A Dales, Natalie Dales
Observed institutions: University of Wisconsin–Madison, University of Michigan, Novartis (United States), Odyssey Therapeutics (United States), ARIAD Pharmaceuticals (United States), Novartis Institutes for BioMedical Research, Takeda Oncology (United States)
ORCID: 0000-0002-2369-7221
Observed ORCID: 0000-0002-2369-7221
OpenAlex ID: A5082166501
ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis
2004 · Paul Towler, Bart Staker, et al. · Journal of Biological Chemistry · 711
SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice
2015 · James Palacino, Susanne E Swalley, et al. · Nature Chemical Biology · 433
Surfactant effects on protein structure examined by electrospray ionization mass spectrometry
1994 · R. R. Ogorzalek Loo, N. Dales, et al. · Protein Science · 189
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Substrate-Based Design of the First Class of Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Inhibitors
2002 · Natalie A. Dales, Alexandra E. Gould, et al. · Journal of the American Chemical Society · 183
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy
2023 · Simone Bonazzi, Eva d’Hennezel, et al. · Cell chemical biology · 170
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Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA)
2018 · Atwood K. Cheung, Brian Hurley, et al. · Journal of Medicinal Chemistry · 137
An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion
2022 · Caroline Gubser Keller, Youngah Shin, et al. · Nature Communications · 126
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A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction
2024 · Pamela Y. Ting, Sneha Borikar, et al. · Science · 104
Opportunities and Challenges in Developing Stearoyl-Coenzyme A Desaturase-1 Inhibitors as Novel Therapeutics for Human Disease
2013 · Zaihui Zhang, Natalie A. Dales, et al. · Journal of Medicinal Chemistry · 90
Enzymatic Characterization of the Pancreatic Islet-specific Glucose-6-Phosphatase-related Protein (IGRP)
2004 · Anthony J. Petrolonis, Qing Yang, et al. · Journal of Biological Chemistry · 57
The Effect of Detergents on Proteins Analyzed by Electrospray Ionization
2003 · Rachele R. Ogorzalek Loo, Natalie Dales, et al. · Humana Press eBooks · 57
Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands
2013 · Josef G. Meingassner, Heinrich Aschauer, et al. · Journal of Investigative Dermatology · 33
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Synthesis of (3R)-Amino-(2S)-Hydroxy Amino Acids for Inhibition of Methionine Aminopeptidase-1
1998 · Stacy J. Keding, Natalie A. Dales, et al. · Synthetic Communications · 31
Design and Synthesis of Unsymmetrical Peptidyl Urea Inhibitors of Aspartic Peptidases
2001 · Natalie A. Dales, Regine S. Bohacek, et al. · Organic Letters · 29
Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO)
2020 · Anup Patnaik, Laura Axford, et al. · Bioorganic & Medicinal Chemistry · 19
Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases
2013 · Shaoyi Sun, Zaihui Zhang, et al. · Bioorganic & Medicinal Chemistry Letters · 19
Use of Intramolecular 1,5-Sulfur–Oxygen and 1,5-Sulfur–Halogen Interactions in the Design of N -Methyl-5-aryl- N -(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 Splicing Modulators
2021 · Jake Axford, Moo Je Sung, et al. · Journal of Medicinal Chemistry · 18
Synthesis of large multideterminant peptide immunogens using a poly-proline beta-turn helix motif.
1993 · J D Fontenot, O J Finn, et al. · PubMed · 18
BET bromodomain inhibitors regulate keratinocyte plasticity
2021 · Gabi Schutzius, Christian Kolter, et al. · Nature Chemical Biology · 17
Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease
2024 · John Ryan Kerrigan, Noel M. Thomsen, et al. · Journal of Medicinal Chemistry · 15
Transformation of Peptides into Non-Peptides. Synthesis of Computer-Generated Enzyme Inhibitors: Computer-Assisted Drug Design
1997 · Daniel H. Rich, Regine S. Bohacek, et al. · CHIMIA International Journal for Chemistry · 14
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Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors
2014 · Shaoyi Sun, Zaihui Zhang, et al. · Bioorganic & Medicinal Chemistry · 13
Targeted Degradation of the Wiz Transcription Factor for Gamma Globin De-Repression
2023 · Pamela Y Ting, Sneha Borikar, et al. · Blood · 10
Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects
2013 · Shaoyi Sun, Zaihui Zhang, et al. · Bioorganic & Medicinal Chemistry Letters · 10
Erratum: Corrigendum: SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice
2016 · James Palacino, Susanne E Swalley, et al. · Nature Chemical Biology · 4
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Works count: 36
Citation count: 2,503
H-index: 18
I10-index: 24
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