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Nicola Giacchè

Observed names: Giacchè N, Giacchè, Nicola, N. Giacche, N. Giacchè, Nicola Giacche, Nicola Giacche', Nicola Giacchè, Nicola Giacche’, Nicola Giacché
Observed institution: University of Perugia
ORCID: 0000-0002-4810-3960
Observed ORCID: 0000-0002-4810-3960
OpenAlex ID: A5083066932
De novo NAD+ synthesis enhances mitochondrial function and improves health
2018 · Elena Katsyuba, Adrienne Mottis, et al. · Nature · 430
Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication
2022 · Marco Gargaro, Giulia Scalisi, et al. · Immunity · 123
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Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure–Activity Relationship, X-ray Crystal Structure, and Anticancer Activity
2017 · Sébastien Moniot, Mariantonietta Forgione, et al. · Journal of Medicinal Chemistry · 108
Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy
2015 · Marsha Pellegrino, Francesca Mancini, et al. · Cancer Research · 48
α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis
2018 · Roberto Pellicciari, Paride Liscio, et al. · Journal of Medicinal Chemistry · 45
Design, synthesis and biological evaluation of novel bicyclo[1.1.1]pentane-based ω-acidic amino acids as glutamate receptors ligands
2008 · Rosanna Filosa, M. Carmela Fulco, et al. · Bioorganic & Medicinal Chemistry · 44
Probing the Binding Site of Bile Acids in TGR5
2013 · Antonio Macchiarulo, Antimo Gioiello, et al. · ACS Medicinal Chemistry Letters · 41
Bulky 1,4-benzoxazine derivatives with antifungal activity
2009 · Renata Fringuelli, Nicola Giacchè, et al. · Bioorganic & Medicinal Chemistry · 38
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies
2022 · Mariagrazia Rullo, Marco Cipolloni, et al. · Journal of Medicinal Chemistry · 36
Concepts and Molecular Aspects in the Polypharmacology of PARP‐1 Inhibitors
2015 · Daniela Passeri, Emidio Camaioni, et al. · ChemMedChem · 33
Targeting the Conformational Transitions of MDM2 and MDMX: Insights into Dissimilarities and Similarities of p53 Recognition
2008 · Antonio Macchiarulo, Nicola Giacchè, et al. · Journal of Chemical Information and Modeling · 29
Computational studies for the elucidation of the enantiomer elution order of amino acids in chiral ligand-exchange chromatography
2010 · Benedetto Natalini, Nicola Giacchè, et al. · Journal of Chromatography A · 20
Expanding the horizon of chemotherapeutic targets: From MDM2 to MDMX (MDM4)
2011 · Antonio Macchiarulo, Nicola Giacchè, et al. · MedChemComm · 16
Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids
2010 · Benedetto Natalini, Roccaldo Sardella, et al. · Analytical and Bioanalytical Chemistry · 15
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization
2024 · Gabriella La Spada, Daniela Valeria Miniero, et al. · European Journal of Medicinal Chemistry · 13
Targeting the conformational transitions of MDM2 and MDMX: Insights into key residues affecting p53 recognition
2009 · Andrea Carotti, Antonio Macchiarulo, et al. · Proteins Structure Function and Bioinformatics · 13
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Oxime and Oxime Ether Derivatives of 1,4‐Benzothiazine Related to Oxiconazole
2007 · Lara Milanese, Nicola Giacchè, et al. · ChemMedChem · 13
Innovations and Emerging Therapies to Combat Renal Cell Damage: NAD + As a Drug Target
2021 · Carlos L. Manrique-Caballero, John A. Kellum, et al. · Antioxidants and Redox Signaling · 10
Structural Basis of Human Dimeric α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025
2022 · Michele Cianci, Nicola Giacchè, et al. · Frontiers in Molecular Biosciences · 8
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Alternative strategies for targeting mouse double minute 2 activity with small molecules: novel patents on the horizon?
2011 · Antonio Macchiarulo, Nicola Giacchè, et al. · Expert Opinion on Therapeutic Patents · 7
Tryptophan pathway profiling in multiple sclerosis patients treated with ocrelizumab
2025 · Carolina Ricci, Matteo Pivetta, et al. · Frontiers in Immunology · 5
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3-O-Methyltolcapone and Its Lipophilic Analogues Are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity
2023 · Thanalai Poonsiri, Davide Dell’Accantera, et al. · International Journal of Molecular Sciences · 4
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3-O-methyltolcapone and Its Lipophilic Analogues are Potent Inhibitors of Transthyretin Amyloidogenesis with High Permeability and Low Toxicity
2023 · Thanalai Poonsiri, Davide dell’Accantera, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
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Use of an o-Benzyl-(S)-Serine Containing Eluent for the Efficient Ligand-Exchange Chromatography-Based Enantioseparation of Constrained Glutamate Receptor Ligands
2014 · Federica Ianni, Roccaldo Sardella, et al. · Analytical Letters · 3
Ligand-exchange enantioresolution of dihydroisoxazole amino acid derivatives acting as glutamatergic modulators
2012 · Roccaldo Sardella, Federica Ianni, et al. · 1
Works count: 41
Citation count: 1,105
H-index: 14
I10-index: 18
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