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Derek K. O’Flaherty

Observed names: D. K. O'Flaherty, D.K. OFlaherty, Derek K O'Flaherty, Derek K O’Flaherty, Derek K. O'Flaherty, Derek K. O′Flaherty, Derek O'Flaherty, Derek O’Flaherty, O'Flaherty, Derek, O'Flaherty, Derek K
Observed institutions: Howard Hughes Medical Institute, Harvard University, Alnylam Pharmaceuticals (United States), Massachusetts General Hospital, Center for Computational and Integrative Biology, Massachusetts General Hospital, Concordia University, University of Guelph
ORCID: 0000-0003-3693-6380
Observed ORCID: 0000-0003-3693-6380
OpenAlex ID: A5083198657
Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides
2017 · Li Li, Noam Prywes, et al. · Journal of the American Chemical Society · 180
Copying of Mixed-Sequence RNA Templates inside Model Protocells
2018 · Derek K. O’Flaherty, Neha P. Kamat, et al. · Journal of the American Chemical Society · 92
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Template‐Directed Copying of RNA by Non‐enzymatic Ligation
2020 · Lijun Zhou, Derek K. O'Flaherty, et al. · Angewandte Chemie International Edition · 74
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A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides
2020 · Seohyun Chris Kim, Lijun Zhou, et al. · Journal of the American Chemical Society · 63
Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3′-NP-DNA up to 25 Nucleotides Long Inside Model Protocells
2019 · Derek K. O’Flaherty, Lijun Zhou, et al. · Journal of the American Chemical Society · 54
The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis
2021 · Seohyun Chris Kim, Derek K. O’Flaherty, et al. · Journal of the American Chemical Society · 53
Thermally Driven Membrane Phase Transitions Enable Content Reshuffling in Primitive Cells
2021 · Roger Rubio-Sánchez, Derek K. O’Flaherty, et al. · Journal of the American Chemical Society · 51
Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA
2018 · Seohyun Chris Kim, Derek K. O’Flaherty, et al. · Proceedings of the National Academy of Sciences · 50
Non-enzymatic primer extension with strand displacement
2019 · Lijun Zhou, Seohyun Chris Kim, et al. · eLife · 47
Assembly of a Ribozyme Ligase from Short Oligomers by Nonenzymatic Ligation
2020 · Lijun Zhou, Derek K. O’Flaherty, et al. · Journal of the American Chemical Society · 43
Steady‐State Kinetic Analysis of DNA Polymerase Single‐Nucleotide Incorporation Products
2014 · Derek K. O'Flaherty, F. Peter Guengerich · Current Protocols in Nucleic Acid Chemistry · 27
Differential stability and dynamics of DNA-based and RNA-based coacervates affect non-enzymatic RNA chemistry
2025 · Karina K. Nakashima, Fatma Zohra Mihoubi, et al. · Nature Communications · 25
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A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension
2017 · Constantin Giurgiu, Li Li, et al. · Journal of the American Chemical Society · 25
Prebiotically Plausible “Patching” of RNA Backbone Cleavage through a 3′–5′ Pyrophosphate Linkage
2019 · Tom H. Wright, Constantin Giurgiu, et al. · Journal of the American Chemical Society · 24
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siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs
2021 · Masaaki Akabane-Nakata, Namrata D Erande, et al. · Nucleic Acids Research · 20
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O4-Alkyl-2′-deoxythymidine cross-linked DNA to probe recognition and repair by O6-alkylguanine DNA alkyltransferases
2012 · Francis P. McManus, Derek K. O'Flaherty, et al. · Organic & Biomolecular Chemistry · 18
Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides
2021 · Mikołaj J. Janicki, Corinna L. Kufner, et al. · The Journal of Physical Chemistry Letters · 17
Template‐Directed Copying of RNA by Non‐enzymatic Ligation
2020 · Lijun Zhou, Derek K. O'Flaherty, et al. · Angewandte Chemie · 16
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DNA polymerase activity on synthetic N3′→P5′ phosphoramidate DNA templates
2019 · Victor S Lelyveld, Derek K O’Flaherty, et al. · Nucleic Acids Research · 16
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A Fluorescent G‐Quadruplex Sensor for Chemical RNA Copying
2018 · Constantin Giurgiu, Tom H. Wright, et al. · Angewandte Chemie International Edition · 14
A Robust Strategy for Introducing Amino‐Modifiers in Nucleic Acids: Enabling Novel Amino Tandem Oligonucleotide Synthesis in DNA and RNA
2025 · Jagandeep S. Saraya, Nicholas G. Horton, et al. · Chemistry - A European Journal · 13
Synthesis, Characterization, and Repair of a Flexible O6‐2′‐Deoxyguanosine‐alkylene‐O6‐2′‐deoxyguanosine Intrastrand Cross‐Link
2015 · Derek K. O'Flaherty, Christopher J. Wilds · Chemistry - A European Journal · 12
Aqueous Compatible Post‐Synthetic On‐Column Conjugation of Nucleic Acids Using Amino‐Modifiers
2024 · Jagandeep S. Saraya, Scott R. Sammons, et al. · ChemBioChem · 11
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Lesion orientation of O 4 -alkylthymidine influences replication by human DNA polymerase η
2016 · D. K. O'Flaherty, A. Patra, et al. · Chemical Science · 11
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A Versatile Disulfide‐Containing Solid‐Support Strategy for 3′‐Modifiers in Oligonucleotides: Introducing Modular Tandem Oligonucleotide Synthesis
2025 · Jagandeep S. Saraya, Nicholas G. Horton, et al. · Chemistry - An Asian Journal · 9
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Works count: 79
Citation count: 1,054
H-index: 17
I10-index: 24
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