Product
Help
Pricing
About
Jobs
Log in
Get started
Author
Add to collection
Lee D. Fader
Observed names:
Fader, Lee D.,
L. D. FADER,
L. D. Fader,
L. Fader,
Lee D Fader,
Lee Fader
show all 6
Institutions:
Acuitas Therapeutics (Canada),
Society for Arts and Technology
Observed institutions:
ETH Zurich,
Boehringer Ingelheim (Canada),
Acuitas Therapeutics (Canada),
Society for Arts and Technology,
Boehringer Ingelheim (United States),
Laboratory of Organic Chemistry,
McGill University,
Concordia University
show all 8
ORCID:
0000-0001-6017-7885
Observed ORCID:
0000-0001-6017-7885
OpenAlex ID:
A5084055397
Works
72
Awards
3
Assessing Atropisomer Axial Chirality in Drug Discovery and Development
2011
·
Steven R. LaPlante
, Lee D. Fader
, et al.
·
Journal of Medicinal Chemistry
·
896
Revealing Atropisomer Axial Chirality in Drug Discovery
2011
·
Steven R. LaPlante
, Paul J. Edwards
, et al.
·
ChemMedChem
·
548
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1
2014
·
Lee D. Fader
, Eric Malenfant
, et al.
·
ACS Medicinal Chemistry Letters
·
177
Arylcyclopropanes: Properties, Synthesis and Use in Medicinal Chemistry
2010
·
Alexandre Gagnon
, Martin Duplessis
, et al.
·
Organic Preparations and Procedures International
·
133
Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein
2012
·
Christopher T. Lemke
, Steve Titolo
, et al.
·
Journal of Virology
·
126
PDF
Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly
2010
·
Lee D. Fader
, Richard Bethell
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
102
Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor
2014
·
Craig Fenwick
, Ma'an Amad
, et al.
·
Antimicrobial Agents and Chemotherapy
·
101
RP-3500: A Novel, Potent, and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors
2021
·
Anne Roulston
, Michal Zimmermann
, et al.
·
Molecular Cancer Therapeutics
·
93
Stereochemically Rich Pentaketides from Bis(isoxazolines): A General Strategy for Efficient Polyketide Synthesis
2004
·
Lee D. Fader
, Erick M. Carreira
·
Organic Letters
·
47
Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500)
2024
·
W. Cameron Black
, Abbas Abdoli
, et al.
·
Journal of Medicinal Chemistry
·
37
Total Synthesis of Bafilomycin A1
2012
·
Florian Kleinbeck
, Gabriela J. Fettes
, et al.
·
Chemistry - A European Journal
·
37
Stereoselective Synthesis of a Thymine Derivative of (S)-2-Hydroxy-4-(2-aminophenyl)butanoic Acid. A Novel Building Block for the Synthesis of Aromatic Peptidic Nucleic Acid Oligomers1
1997
·
Youla S. Tsantrizos
, Jacqueline F. Lunetta
, et al.
·
The Journal of Organic Chemistry
·
29
Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs
2016
·
Lee D. Fader
, Murray Bailey
, et al.
·
ACS Medicinal Chemistry Letters
·
27
Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV
2014
·
Lee D. Fader
, Rebekah Carson
, et al.
·
ACS Medicinal Chemistry Letters
·
22
Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: Structure–activity relationships (SAR) of the C3-phenyl moiety
2013
·
Lee D. Fader
, Serge Landry
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
20
Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: Addressing configurational instability through scaffold modification
2013
·
Lee D. Fader
, Serge Landry
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
17
Backbone Modifications of Aromatic Peptide Nucleic Acid (APNA) Monomers and Their Hybridization Properties with DNA and RNA
2001
·
Lee D. Fader
, Michael Boyd
, et al.
·
The Journal of Organic Chemistry
·
17
Monitoring Binding of HIV‐1 Capsid Assembly Inhibitors Using 19F Ligand‐and 15N Protein‐Based NMR and X‐ray Crystallography: Early Hit Validation of a Benzodiazepine Series
2013
·
Nathalie Goudreau
, René Coulombe
, et al.
·
ChemMedChem
·
14
PDF
Structural insight into the cGAS active site explains differences between therapeutically relevant species
2025
·
Alexander M. Skeldon
, Li Wang
, et al.
·
Communications Chemistry
·
13
Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity
2017
·
Kenneth Meyers
, Derek A. Cogan
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
13
Novel pyridone EP4 agonists featuring allylic alcohol ω-chains
2020
·
Stéphane Dorich
, Jennifer H. Cox
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
9
Synthesis of novel analogs of aromatic peptide nucleic acids (APNAs) with modified conformational and electrostatic properties
2004
·
Lee D Fader
, Eddie L Myers
, et al.
·
Tetrahedron
·
9
Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization
2024
·
Patrick Cyr
, Lee D. Fader
, et al.
·
ACS Medicinal Chemistry Letters
·
7
PDF
Discovery of Potent, Orally Bioavailable Inhibitors of Human Cytomegalovirus
2016
·
Lee Fader
, Martine Brault
, et al.
·
ACS Medicinal Chemistry Letters
·
7
Hybridization Properties of Aromatic Peptide Nucleic Acids: A Novel Class of Oligonucleotide Analogues
2001
·
Lee D. Fader
, Youla S. Tsantrizos
·
Organic Letters
·
7
Show more works
View as search
Works count:
72
Citation count:
2,518
H-index:
17
I10-index:
20
Year
Topic
Type
