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James M. Trevillyan

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.
1988 · C E Rudd, J M Trevillyan, et al. · Proceedings of the National Academy of Sciences · 686
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.
1989 · E K Barber, J D Dasgupta, et al. · Proceedings of the National Academy of Sciences · 449
PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice
2002 · Bradley A. Zinker, Cristina M. Rondinone, et al. · Proceedings of the National Academy of Sciences · 416
Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
2003 · Bruce G. Szczepankiewicz, Gang Liu, et al. · Journal of the American Chemical Society · 232
Reduction of Protein Tyrosine Phosphatase 1B Increases Insulin-Dependent Signaling in ob/ob Mice
2003 · Rebecca J. Gum, Lori L. Gaede, et al. · Diabetes · 201
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Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line
2002 · Wiweka Kaszubska, H.Douglas Falls, et al. · Molecular and Cellular Endocrinology · 190
T cell activation induces a noncoding RNA transcript sensitive to inhibition by immunosuppressant drugs and encoded by the proto-oncogene, BIC
2002 · Deanna Haasch, Yung-Wu Chen, et al. · Cellular Immunology · 189
Fragment Screening and Assembly: A Highly Efficient Approach to a Selective and Cell Active Protein Tyrosine Phosphatase 1B Inhibitor
2003 · Gang Liu, Zhili Xin, et al. · Journal of Medicinal Chemistry · 165
Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity
2006 · Bruce G. Szczepankiewicz, Christi Kosogof, et al. · Journal of Medicinal Chemistry · 163
Protein Tyrosine Phosphatase 1B Reduction Regulates Adiposity and Expression of Genes Involved in Lipogenesis
2002 · Cristina M. Rondinone, James M. Trevillyan, et al. · Diabetes · 158
A Dominant-negative p38 MAPK Mutant and Novel Selective Inhibitors of p38 MAPK Reduce Insulin-stimulated Glucose Uptake in 3T3-L1 Adipocytes without Affecting GLUT4 Translocation
2002 · Romel Somwar, Sandra Koterski, et al. · Journal of Biological Chemistry · 135
Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin‐mediated angioedema
2007 · R M Fryer, J Segreti, et al. · British Journal of Pharmacology · 128
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3,5-Bis(trifluoromethyl)pyrazoles: A Novel Class of NFAT Transcription Factor Regulator
2000 · Stevan W. Djuric, Nwe Y. BaMaung, et al. · Journal of Medicinal Chemistry · 120
Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands
2003 · Gang Liu, Zhili Xin, et al. · Journal of Medicinal Chemistry · 109
Potent Inhibition of NFAT Activation and T Cell Cytokine Production by Novel Low Molecular Weight Pyrazole Compounds
2001 · James M. Trevillyan, X. Grace Chiou, et al. · Journal of Biological Chemistry · 103
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Differential inhibition of T cell receptor signal transduction and early activation events by a selective inhibitor of protein-tyrosine kinase.
1990 · J M Trevillyan, Y Lu, et al. · The Journal of Immunology · 101
Discovery and Structure−Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors
2007 · Zhonghua Pei, Xiaofeng Li, et al. · Journal of Medicinal Chemistry · 93
Insulin- and phorbol ester-stimulated phosphorylation of ribosomal protein S6.
1985 · J M Trevillyan, O Perisic, et al. · Journal of Biological Chemistry · 88
CD28-induced T cell activation. Evidence for a protein-tyrosine kinase signal transduction pathway
1992 · Y Lu, A Granelli-Piperno, et al. · The Journal of Immunology · 86
Isoxazole carboxylic acids as protein tyrosine phosphatase 1B (PTP1B) inhibitors
2004 · Hongyu Zhao, Gang Liu, et al. · Bioorganic & Medicinal Chemistry Letters · 84
Zotarolimus, a Novel Sirolimus Analogue With Potent Anti-proliferative Activity on Coronary Smooth Muscle Cells and Reduced Potential for Systemic Immunosuppression
2007 · Yung-Wu Chen, Morey L Smith, et al. · Journal of Cardiovascular Pharmacology · 83
Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors
2006 · Hongyu Zhao, Michael D. Serby, et al. · Journal of Medicinal Chemistry · 77
Tumor-promoting phorbol esters stimulate the phosphorylation of ribosomal protein S6 in quiescent Reuber H35 hepatoma cells.
1984 · J M Trevillyan, R K Kulkarni, et al. · Journal of Biological Chemistry · 76
Control of cyclic adenosine 3',5'-monophosphate levels by depolarizing agents in fungi
1979 · J M Trevillyan, M L Pall · Journal of Bacteriology · 73
c-Jun N-terminal kinase pathways in diabetes
2008 · Ruojing Yang, James M. Trevillyan · The International Journal of Biochemistry & Cell Biology · 69
Works count: 87
Citation count: 5,775
H-index: 40
I10-index: 66
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