Author

Douglas J. Kornbrust

Observed names: D J Kornbrust, D KORNBRUST, D Kornbrust, D. J. Kornbrust, D. Kornbrust, D.J. Kornbrust, DOUGLAS J. KORNBRUST, DOUGLAS KORNBRUST, Doug J. Kornbrust, Doug Kornbrust, Douglas J Kornbrust, Douglas Kornbrust, Kornbrust, D. J.

Observed institutions: Merck & Co., Inc., Rahway, NJ, USA (United States), RTI International, The University of Texas at Tyler, Ionis Pharmaceuticals (United States), University of Rochester Medicine, National Jewish Health, National Institute of Environmental Health Sciences, Geron (United States), Sierra BioMedical (United States), University of Rochester

OpenAlex ID: A5084958659

Relative susceptibility of microsomes from lung, heart, liver, kidney, brain and testes to lipid peroxidation: Correlation with vitamin E content

1980 · Douglas J. Kornbrust, Richard D. Mavis · Lipids · 410

Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA

2007 · Jeremy D. Heidel, Zhongping Yu, et al. · Proceedings of the National Academy of Sciences · 391

First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder

2009 · Sancy A Leachman, Robyn P Hickerson, et al. · Molecular Therapy · 266

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Pharmacokinetic properties of several novel oligonucleotide analogs in mice.

1996 · S T Crooke, M J Graham, et al. · Journal of Pharmacology and Experimental Therapeutics · 230

Activation of the Alternative Pathway of Complement by a Phosphorothioate Oligonucleotide: Potential Mechanism of Action

1997 · Scott P. Henry, Patricia C. Giclas, et al. · Journal of Pharmacology and Experimental Therapeutics · 207

Preclinical evaluation of lovastatin

1988 · James S. MacDonald, Ronald J. Gerson, et al. · The American Journal of Cardiology · 199

An ICAM-1 Antisense Oligonucleotide Prevents and Reverses Dextran Sulfate Sodium-Induced Colitis in Mice

1997 · C. Frank Bennett, Doug Kornbrust, et al. · Journal of Pharmacology and Experimental Therapeutics · 188

Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide

2002 · Scott P Henry, Greg Beattie, et al. · International Immunopharmacology · 156

Animal safety and toxicology of simvastatin and related hydroxy-methylglutaryl-coenzyme a reductase inhibitors

1989 · Ronald J. Gerson, James S. Macdonald, et al. · The American Journal of Medicine · 136

Microsomal lipid peroxidation. I. Characterization of the role of iron and NADPH.

1980 · D J Kornbrust, R D Mavis · PubMed · 135

Testing of 24 food, drug, cosmetic, and fabric dyes in the in vitro and the in vivo/in vitro rat hepatocyte primary culture DNA repair assays

1985 · Douglas Kornbrust, Thomas Barfknecht · Environmental Mutagenesis · 128

Inhibition of Coagulation by a Phosphorothioate Oligonucleotide

1997 · SCOTT P. HENRY, WILLIAM NOVOTNY, et al. · Antisense and Nucleic Acid Drug Development · 122

Evaluation of the toxicity of ISIS 2302, a phosphorothioate oligonucleotide, in a four-week study in cynomolgus monkeys

1997 · Scott P. Henry, Henry Bolte, et al. · Toxicology · 118

Assessing unintended hybridization-induced biological effects of oligonucleotides

2012 · Morten Lindow, Hans-Peter Vornlocher, et al. · Nature Biotechnology · 112

Evaluation of the Toxicity of ISIS 2302, a Phosphorothioate Oligonucleotide, in a 4-Week Study in CD-1 Mice

1997 · SCOTT P. HENRY, JACK TAYLOR, et al. · Antisense and Nucleic Acid Drug Development · 102

Toxicity of the HMG-coenzyme A reductase inhibitor, lovastatin, to rabbits.

1989 · D J Kornbrust, J S MacDonald, et al. · Journal of Pharmacology and Experimental Therapeutics · 96

Toxicological and Pharmacokinetic Properties of QPI-1007, a Chemically Modified Synthetic siRNA Targeting Caspase 2 mRNA, Following Intravitreal Injection

2014 · Elisabeth C.R. Solano, Douglas J. Kornbrust, et al. · Nucleic Acid Therapeutics · 93

Toxicological and Pharmacokinetic Properties of Chemically Modified siRNAs Targeting p53 RNA Following Intravenous Administration

2012 · James D. Thompson, Douglas J. Kornbrust, et al. · Nucleic Acid Therapeutics · 85

The effect of paraquat on microsomal lipid peroxidation in vitro and in vivo

1980 · Douglas J. Kornbrust, Richard D. Mavis · Toxicology and Applied Pharmacology · 75

Oligodeoxynucleotide Studies in Primates: Antisense and Immune Stimulatory Indications

2003 · Cindy A. Farman, Doug J. Kornbrust · Toxicologic Pathology · 72

Pharmacokinetics of a potential human cytomegalovirus therapeutic, a phosphorothioate oligonucleotide, after intravitreal injection in the rabbit.

1997 · J M Leeds, S P Henry, et al. · PubMed · 71

The role of glutathione and cytochrome P-450 in the metabolism of methyl chloride

1983 · Douglas J. Kornbrust, James S. Bus · Toxicology and Applied Pharmacology · 62

Microsomal Lipid Peroxidation

1980 · DOUGLAS J. KORNBRUST, RICHARD D. MAVIS · Molecular Pharmacology · 58

Ocular biodistribution of bevasiranib following a single intravitreal injection to rabbit eyes.

2008 · Nadine S Dejneka, Shanhong Wan, et al. · PubMed Central · 53

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Comparison of 7 azo dyes and their azo reduction products in the rat and hamster hepatocyte primary culture/DNA-repair assays

1984 · Douglas J. Kornbrust, Thomas R. Barfknecht · Mutation Research/Genetic Toxicology · 52

Works count: 71

Citation count: 4,397

H-index: 35

I10-index: 49