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Thomas Botton

CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing
2016 · Eric Talevich, A. Hunter Shain, et al. · PLoS Computational Biology · 2,130
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Kinase fusions are frequent in Spitz tumours and spitzoid melanomas
2014 · Thomas Wiesner, Jie He, et al. · Nature Communications · 660
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Metformin inhibits melanoma development through autophagy and apoptosis mechanisms
2011 · T Tomic, T Botton, et al. · Cell Death and Disease · 315
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Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway
2015 · A Hunter Shain, Maria Garrido, et al. · Nature Genetics · 289
Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance
2016 · Michaël Cerezo, Abdelali Lehraiki, et al. · Cancer Cell · 273
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Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny
2011 · Y Cheli, S Guiliano, et al. · Oncogene · 249
Activating MET kinase rearrangements in melanoma and Spitz tumours
2015 · Iwei Yeh, Thomas Botton, et al. · Nature Communications · 173
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NTRK3 kinase fusions in Spitz tumours
2016 · Iwei Yeh, Meng Kian Tee, et al. · The Journal of Pathology · 158
Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation
2018 · Hanlin Zeng, Aparna Jorapur, et al. · Cancer Cell · 150
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Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy
2013 · Thomas Botton, Iwei Yeh, et al. · Pigment Cell & Melanoma Research · 147
Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses
2019 · Thomas Botton, Eric Talevich, et al. · Cell Reports · 113
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Clinical activity of the MEK inhibitor trametinib in metastatic melanoma containing BRAF kinase fusion
2015 · Alexander M. Menzies, Iwei Yeh, et al. · Pigment Cell & Melanoma Research · 85
In Vitro and In Vivo Anti-Melanoma Effects of Ciglitazone
2009 · Thomas Botton, Alexandre Puissant, et al. · Journal of Investigative Dermatology · 68
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Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth
2010 · T Botton, A Puissant, et al. · Cell Death and Differentiation · 46
Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance
2016 · Michaël Cerezo, Abdelali Lehraiki, et al. · Cancer Cell · 42
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Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies
2021 · Emilie Jaune, Elisa Cavazza, et al. · Cell Death and Disease · 35
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Rac1 Dynamics in the Human Opportunistic Fungal Pathogen Candida albicans
2010 · Romain Vauchelles, Danièle Stalder, et al. · PLoS ONE · 22
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Vitiligo auto‐immune response upon oxidative stress‐related mitochondrial DNA release opens up new therapeutic strategies
2024 · Ana C. B. Sant'Anna‐Silva, Thomas Botton, et al. · Clinical and Translational Medicine · 19
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Melanoma BRAF Fusions—Letter
2014 · Thomas Botton, Iwei Yeh, et al. · Clinical Cancer Research · 9
Hybrid Capture-Based Tumor Sequencing and Copy Number Analysis to Confirm Origin of Metachronous Metastases in BRCA1-Mutant Cholangiocarcinoma Harboring a Novel YWHAZ-BRAF Fusion
2018 · Huat C. Lim, Meagan Montesion, et al. · The Oncologist · 5
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Comment on ‘Testing for BRAF fusions in patients with advanced BRAF/NRAS/KIT wild-type melanomas permits to identify patients who could benefit of anti-MEK targeted therapy’
2019 · Thomas Botton, Thierry Passeron, et al. · Journal of Clinical Pathology · 2
Abstract 2968: Exome sequencing of desmoplastic melanoma reveals recurrent NFKBIE promoter mutations and diverse MAPK/PI3K pathway activating mutations
2015 · Alan H. Shain, Maria Garrido, et al. · Cancer Research · 2
Design, Synthesis and Biological Evaluation of Novel Anticancer Amidinourea Analogues via Unexpected 1,3,5‐Triazin‐2‐one Ring Opening
2023 · Oleksandr Grytsai, Nedra Hamouda‐Tekaya, et al. · ChemMedChem · 1
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Dual targeting of GPX4 and TXNRD1 triggers eradication of AML cells through induction of apoptosis and ferroptosis
2026 · Cécile Favreau, Maxence Bourgoin, et al. · Experimental Hematology and Oncology
MELK controls tumor metabolism to promote resistance to melanoma therapy
2025 · Ana Carolina B. Sant’Anna-Silva, Patricia Abbe, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Works count: 35
Citation count: 4,993
H-index: 18
I10-index: 18
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