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Author

Qing Cheng

Observed names: Cheng, Qing, Q Cheng, Q. Cheng
ORCID: 0000-0002-3170-9333
Observed ORCID: 0000-0002-3170-9333
OpenAlex ID: A5085491395
A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems
2016 · Éva Dóka, Irina Pader, et al. · Science Advances · 328
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The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1
2023 · Dorian M. Cheff, Chuying Huang, et al. · Redox Biology · 255
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
2018 · William C. Stafford, Xiaoxiao Peng, et al. · Science Translational Medicine · 240
Crystal Structure and Catalysis of the Selenoprotein Thioredoxin Reductase 1
2008 · Qing Cheng, Tatyana Sandalova, et al. · Journal of Biological Chemistry · 228
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Control of protein function through oxidation and reduction of persulfidated states
2020 · É. Dóka, T. Ida, et al. · Science Advances · 211
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Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors
2010 · Oliver Rackham, Anne-Marie J. Shearwood, et al. · Free Radical Biology and Medicine · 121
Direct Observation of Methylmercury and Auranofin Binding to Selenocysteine in Thioredoxin Reductase
2020 · Ingrid J. Pickering, Qing Cheng, et al. · Inorganic Chemistry · 80
Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depleted Escherichia coli Host Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation
2017 · Qing Cheng, Elias S.J. Arnér · Journal of Biological Chemistry · 78
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Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans
2011 · Jörgen Stenvall, Juan Carlos Fierro-González, et al. · Proceedings of the National Academy of Sciences · 77
The Selenium-independent Inherent Pro-oxidant NADPH Oxidase Activity of Mammalian Thioredoxin Reductase and Its Selenium-dependent Direct Peroxidase Activities
2010 · Qing Cheng, William E. Antholine, et al. · Journal of Biological Chemistry · 70
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System-wide identification and prioritization of enzyme substrates by thermal analysis
2021 · Amir Ata Saei, Christian M. Beusch, et al. · Nature Communications · 67
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Bicarbonate is essential for protein-tyrosine phosphatase 1B (PTP1B) oxidation and cellular signaling through EGF-triggered phosphorylation cascades
2019 · Markus Dagnell, Qing Cheng, et al. · Journal of Biological Chemistry · 65
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Side-by-side comparison of recombinant human glutathione peroxidases identifies overlapping substrate specificities for soluble hydroperoxides
2023 · Maria Schwarz, Alina Löser, et al. · Redox Biology · 59
Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin
2021 · Pierre Sabatier, Christian M. Beusch, et al. · Redox Biology · 56
Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities
2016 · Jianqiang Xu, Qing Cheng, et al. · Free Radical Biology and Medicine · 56
Selective cellular probes for mammalian thioredoxin reductase TrxR1: Rational design of RX1, a modular 1,2-thiaselenane redox probe
2022 · Lukas Zeisel, Jan G. Felber, et al. · Chem · 48
The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death
2015 · J Xu, S E Eriksson, et al. · Cell Death and Disease · 48
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Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure
2017 · Markus Dagnell, Paul E. Pace, et al. · Journal of Biological Chemistry · 46
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Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases
2022 · Radosveta Gencheva, Qing Cheng, et al. · Free Radical Biology and Medicine · 44
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Prolonged antigen‐exposure with carbohydrate particle based vaccination prevents allergic immune responses in sensitized mice
2009 · S. Thunberg, T. Neimert‐Andersson, et al. · Allergy · 43
Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay
2011 · Stefanie Prast-Nielsen, Thomas S. Dexheimer, et al. · Free Radical Biology and Medicine · 42
Tagging recombinant proteins with a Sel-tag for purification, labeling with electrophilic compounds or radiolabeling with 11C
2006 · Qing Cheng, Sharon Stone-Elander, et al. · Nature Protocols · 40
Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4
2023 · Dorian M. Cheff, Qing Cheng, et al. · Redox Biology · 39
Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy
2017 · Alexei P. Kudin, Gregor Baron, et al. · Free Radical Biology and Medicine · 39
Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry
2018 · Ilaria Silvestri, Haining Lyu, et al. · ACS Chemical Biology · 38
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Works count: 84
Citation count: 2,980
H-index: 30
I10-index: 48
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