Author

Thomas M. Leurgans

Observed names: Leurgans, T.M., Leurgans, Thomas, T M Leurgans, T. Leurgans, TM Leurgans, Thomas Leurgans, Thomas M Leurgans

Institution: University of Southern Denmark

Observed institutions: University of Southern Denmark, Maastricht University, Centre for Individualised Medicine in Arterial Diseases

ORCID: 0000-0001-6912-3699

Observed ORCID: 0000-0001-6912-3699

OpenAlex ID: A5086365673

Early impairment of skeletal muscle endothelial glycocalyx barrier properties in diet-induced obesity in mice

2014 · Bart J. M. Eskens, Thomas M. Leurgans, et al. · Physiological Reports · 33

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Elastin Organization in Pig and Cardiovascular Disease Patients' Pericardial Resistance Arteries

2015 · Maria Bloksgaard, Thomas M. Leurgans, et al. · Journal of Vascular Research · 23

Imaging and modeling of acute pressure-induced changes of collagen and elastin microarchitectures in pig and human resistance arteries

2017 · Maria Bloksgaard, Thomas M. Leurgans, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 21

Endothelin‐1 shifts the mediator of bradykinin‐induced relaxation from NO to H2O2in resistance arteries from patients with cardiovascular disease

2016 · Thomas M Leurgans, Maria Bloksgaard, et al. · British Journal of Pharmacology · 18

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25Years of endothelin research: the next generation

2014 · Noriaki Emoto, Nicolas Vignon-Zellweger, et al. · Life Sciences · 11

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The angiotensin AT2-receptor agonist compound 21 is an antagonist for the thromboxane TP-receptor – Implications for preclinical studies and future clinical use

2023 · Maise H. Fredgart, Thomas M. Leurgans, et al. · Peptides · 5

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Relaxing Responses to Hydrogen Peroxide and Nitric Oxide in Human Pericardial Resistance Arteries Stimulated with Endothelin‐1

2017 · Thomas M. Leurgans, Maria Bloksgaard, et al. · Basic & Clinical Pharmacology & Toxicology · 4

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Abstract P143: The Angiotensin AT2 Receptor Agonist Compound 21 Is a Low Affinity Thromboxane A2 Receptor Antagonist

2015 · Ulrike M Steckelings, Maise Fredgart, et al. · Hypertension · 4

Conference Calendar

2015 · Maria Bloksgaard, Thomas M. Leurgans, et al. · Journal of Vascular Research · 2

Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascu

2016 · V Garcia-Martinez, C Lopez Sanchez, et al. · Cardiovascular Research · 1

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PP.14.22

2015 · M. Fredgart, T. Leurgans, et al. · Journal of Hypertension · 1

P178Responses to endothelium-dependent vasodilators and insulin in patient pericardial resistance arteries

2014 · TM Leurgans, LM Rasmussen, et al. · Cardiovascular Research · 1

P239Human resistance artery relaxing responses to an angiotensin AT2 receptor agonist depend on the type of contractile stimulus

2014 · M H Fredgart, T M Leurgans, et al. · Cardiovascular Research · 1

Inverse relationship between the media-to-lumen ratio and smooth muscle contractile function in resistance arteries from patients with residual cardiovascular disease

2018 · Bloksgaard, Maria ; id_orcid 0000-0002-4474-9553, Möller, Sören; id_orcid 0000-0003-0858-4269, et al. · University of Southern Denmark Research Portal (University of Southern Denmark)

Combined use of β-Blockers and Inhibitors of the Renin-Angiotensin System Decreases the Stiffness of Resistance Arteries from Cardiothoracic Surgery Patients

2017 · Bloksgaard, Maria ; id_orcid 0000-0002-4474-9553, Leurgans, Thomas, et al. · University of Southern Denmark Research Portal (University of Southern Denmark)

Determinants of the Maximal contractile Reactivity of Pericardial Resistance Arteries from Cardio-Thoracic Surgery Patients

2017 · Maria Bloksgaard, Jo G. R. De Mey, et al. · University of Southern Denmark Research Portal (University of Southern Denmark)

Combined chronic treatment with β-blocker and inhibitor of the renin-angiotensin system decreases human resistance artery stiffness in hypertensive patients

2017 · Maria Bloksgaard, Thomas Leurgans, et al. · University of Southern Denmark Research Portal (University of Southern Denmark)

Contractile agonist-dependent relaxing responses in pericardial resistance arteries from patients with cardiovascular disease

2017 · Thomas Leurgans · University of Southern Denmark Research Portal (University of Southern Denmark)

Effects of nitric oxide and hydrogen peroxide in resistance arteries from CVD patients depend on vasoconstrictor conditions

2015 · Thomas Leurgans, Lars Melholt Rasmussen, et al. · University of Southern Denmark Research Portal (University of Southern Denmark)

Endothelin-1 shifts the mediator of bradykinin-induced contractions from NO to H2O2 in resistance arteries from cardiovascular disease patients

2015 · Leurgans, Thomas, Rasmussen, Lars Melholt, et al. · University of Southern Denmark Research Portal (University of Southern Denmark)

In cardiovascular disease patients’ pericardial resistance arteries, the roles of H2O2 and endothelium-derived relaxing factors in bradykinin-induced relaxations depend on the contractile stimulus

2015 · Thomas Leurgans, Maria Bloksgaard, et al. · University of Southern Denmark Research Portal (University of Southern Denmark)

Contributions of H2O2 and endothelium-derived relaxing factors in cardiovascular disease patients' pericardial resistance arteries depend on the contractile stimulus

2015 · Leurgans, Thomas, Hansen, Maria Lyck, et al. · University of Southern Denmark Research Portal (University of Southern Denmark)

Supplementary Material for: Elastin Organization in Pig and Cardiovascular Disease Patients' Pericardial Resistance Arteries

2015 · Bloksgaard, M., Leurgans, T.M., et al. · Figshare

Patients' pericardial resistance artery responses to bradykinin and insulin involve hydrogen peroxide

2014 · Leurgans, Thomas, Rasmussen, Lars Melholt, et al. · University of Southern Denmark Research Portal (University of Southern Denmark)

Pericardial resistance arteries show biaxial mechanics and pressure dependent microarchitecture of the extracellular matrix

2014 · Maria Bloksgaard, Thomas Leurgans, et al. · University of Southern Denmark Research Portal (University of Southern Denmark)

Works count: 36

Citation count: 125

H-index: 5

I10-index: 5