Get started
Author

Emanuele Gabellieri

Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies
2019 · Heiko Kroth, Felix Oden, et al. · European Journal of Nuclear Medicine and Molecular Imaging · 223
PDF
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain
2016 · Margherita Brindisi, Samuele Maramai, et al. · Journal of Medicinal Chemistry · 85
PDF
Mimicking the Intramolecular Hydrogen Bond: Synthesis, Biological Evaluation, and Molecular Modeling of Benzoxazines and Quinazolines as Potential Antimalarial Agents
2012 · Sandra Gemma, Caterina Camodeca, et al. · Journal of Medicinal Chemistry · 62
Conformational Flexibility in the Peripheral Site of Torpedo californica Acetylcholinesterase Revealed by the Complex Structure with a Bifunctional Inhibitor
2006 · Jacques Ph. Colletier, Benoît Sanson, et al. · Journal of the American Chemical Society · 56
BACE1 inhibitors: A head group scan on a series of amides
2013 · Thomas J. Woltering, Wolfgang Wostl, et al. · Bioorganic & Medicinal Chemistry Letters · 53
Discovery of Huperzine A−Tacrine Hybrids as Potent Inhibitors of Human Cholinesterases Targeting Their Midgorge Recognition Sites
2006 · Sandra Gemma, Emanuele Gabellieri, et al. · Journal of Medicinal Chemistry · 50
Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues
2010 · Sandra Gemma, Emanuele Gabellieri, et al. · The Journal of Organic Chemistry · 48
Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials
2009 · Sandra Gemma, Francesc Martí, et al. · Tetrahedron Letters · 26
An Efficient Approach to Chiral C8/C9-Piperazino-Substituted 1,4-Benzodiazepin-2-ones as Peptidomimetic Scaffolds
2008 · Stefania Butini, Emanuele Gabellieri, et al. · The Journal of Organic Chemistry · 26
PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer’s Disease and Other Tauopathies
2021 · Heiko Kroth, Felix Oden, et al. · Journal of Medicinal Chemistry · 20
A stereoselective approach to peptidomimetic BACE1 inhibitors
2013 · Stefania Butini, Emanuele Gabellieri, et al. · European Journal of Medicinal Chemistry · 17
Novel peptidomimetics as BACE-1 inhibitors: Synthesis, molecular modeling, and biological studies
2012 · Stefania Butini, Emanuele Gabellieri, et al. · Bioorganic & Medicinal Chemistry Letters · 15
Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core
2021 · Heiko Kroth, Felix Oden, et al. · Bioorganic & Medicinal Chemistry · 9
Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c’]dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer’s disease and other tauopathies
2020 · Emanuele Gabellieri, Francesca Capotosti, et al. · European Journal of Medicinal Chemistry · 8
Elimination of tau tangles and soluble aggregates with the small molecule ACI‐16664 prevents neurodegeneration in vivo
2026 · Nicolas Preitner, Véronique Dehlinger, et al. · Alzheimer s & Dementia
O5‐06‐03: Small Molecules Targeting Tau Aggregation Decrease Tau Pathology and Neuroinflammation in Vivo
2019 · Francesca Capotosti, Sreenivasachary Nampally, et al. · Alzheimer s & Dementia
Works count: 16
Citation count: 698
H-index: 12
I10-index: 12
Year
Topic
Type