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Amir Faisal
Observed names:
A Faisal,
A. Faisal,
AMIR FAISAL,
Amir FAISAL,
Faisal, Amir
Institution:
Lahore University of Management Sciences
Observed institutions:
Royal Marsden NHS Foundation Trust,
Institute of Cancer Research,
Lahore University of Management Sciences,
Cancer Research UK,
NeuroSearch (Denmark),
University of Technology Malaysia,
Kitasato University,
Friedrich Miescher Institute
show all 8
ORCID:
0000-0002-7376-8286
Observed ORCID:
0000-0002-7376-8286
OpenAlex ID:
A5087031667
Works
142
Awards
1
The regulated assembly of a PKCɛ complex controls the completion of cytokinesis
2008
·
Adrian T. Saurin
, Joanne Durgan
, et al.
·
Nature Cell Biology
·
134
Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns
2012
·
A S Moore
, A Faisal
, et al.
·
Leukemia
·
121
Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA
2002
·
Malgorzata KISIELOW
, Sandra KLEINER
, et al.
·
Biochemical Journal
·
95
The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes MYCN -Amplified Neuroblastoma In Vivo
2011
·
Amir Faisal
, Lynsey Vaughan
, et al.
·
Molecular Cancer Therapeutics
·
91
PDF
Imidazo[4,5-b]pyridine Derivatives As Inhibitors of Aurora Kinases: Lead Optimization Studies toward the Identification of an Orally Bioavailable Preclinical Development Candidate
2010
·
Vassilios Bavetsias
, Jonathan M. Large
, et al.
·
Journal of Medicinal Chemistry
·
88
Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3,2-c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)
2013
·
Sébastien Naud
, Isaac M. Westwood
, et al.
·
Journal of Medicinal Chemistry
·
83
p66 Inhibits Pro-survival Epidermal Growth Factor Receptor/ERK Signaling during Severe Oxidative Stress in Mouse Renal Proximal Tubule Cells
2008
·
Istvan Arany
, Amir Faisal
, et al.
·
Journal of Biological Chemistry
·
82
Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-b]pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells
2013
·
Vassilios Bavetsias
, Amir Faisal
, et al.
·
Journal of Medicinal Chemistry
·
79
PDF
Optimization of Imidazo[4,5-b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia
2012
·
Vassilios Bavetsias
, Simon Crumpler
, et al.
·
Journal of Medicinal Chemistry
·
77
PDF
Hydrothermal synthesis of carbon nanodots from bovine gelatin and PHM3 microalgae strain for anticancer and bioimaging applications
2019
·
Mishal Amjad
, Maheen Iqbal
, et al.
·
Nanoscale Advances
·
66
PDF
Colon specific enzyme responsive oligoester crosslinked dextran nanoparticles for controlled release of 5-fluorouracil
2020
·
Mehwish Abid
, Muhammad Naveed
, et al.
·
International Journal of Pharmaceutics
·
65
p66SHC-mediated mitochondrial dysfunction in renal proximal tubule cells during oxidative injury
2010
·
Istvan Arany
, Amir Faisal
, et al.
·
American Journal of Physiology-Renal Physiology
·
58
The Scaffold MyD88 Acts to Couple Protein Kinase Cϵ to Toll-like Receptors
2008
·
Amir Faisal
, Adrian Saurin
, et al.
·
Journal of Biological Chemistry
·
52
PDF
Synthesis and evaluation of novel α-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance
2019
·
Sharon Riaz
, Maheen Iqbal
, et al.
·
Bioorganic Chemistry
·
50
Cisplatin induces apoptosis through the ERK–p66shc pathway in renal proximal tubule cells
2010
·
Jeb S. Clark
, Amir Faisal
, et al.
·
Cancer Letters
·
47
Serine/Threonine Phosphorylation of ShcA
2002
·
Amir Faisal
, Mahmoud El-Shemerly
, et al.
·
Journal of Biological Chemistry
·
47
PDF
Spontaneous NETosis in diabetes: A role of hyperglycemia mediated ROS and autophagy
2023
·
Anam Farhan
, Ghulam Hassan
, et al.
·
Frontiers in Medicine
·
46
High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
2019
·
Simon J. Anderhub
, Grace Wing-Yan Mak
, et al.
·
Molecular Cancer Therapeutics
·
45
A Cancer-associated Aurora A Mutant Is Mislocalized and Misregulated Due to Loss of Interaction with TPX2
2009
·
Rachel Ann Bibby
, Chan Tang
, et al.
·
Journal of Biological Chemistry
·
44
PDF
Combined 3D-QSAR, molecular docking and dynamics simulations studies to model and design TTK inhibitors
2022
·
Noureen Ashraf
, Asnuzilawati Asari
, et al.
·
Frontiers in Chemistry
·
41
Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4- d ]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N 2-(2-Ethoxy-4-(4-methyl-4 H -1,2,4-triazol-3-yl)phenyl)-6-methyl- N 8-neopentylpyrido[3,4- d ]pyrimidine-2,8-diamine (BOS172722)
2018
·
Hannah L. Woodward
, Paolo Innocenti
, et al.
·
Journal of Medicinal Chemistry
·
40
Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis
2016
·
Mark D. Gurden
, Simon J. Anderhub
, et al.
·
Oncotarget
·
39
PDF
Protein kinases, from B to C
2007
·
A.J. Cameron
, M. De Rycker
, et al.
·
Biochemical Society Transactions
·
38
Synthesis and evaluation of modified chalcone based p53 stabilizing agents
2017
·
Sunniya Iftikhar
, Sardraz Khan
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
37
Reduction-Sensitive Dextran–Paclitaxel Polymer–Drug Conjugate: Synthesis, Self-Assembly into Nanoparticles, and In Vitro Anticancer Efficacy
2021
·
Sidra Kanwal
, Muhammad Naveed
, et al.
·
Bioconjugate Chemistry
·
36
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Works count:
142
Citation count:
2,295
H-index:
30
I10-index:
52
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