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Alex H. Y. Chan

Observed names: Alex H Y Chan, Alex H.Y. Chan
ORCID: 0009-0006-7897-4560
Observed ORCID: 0009-0006-7897-4560
OpenAlex ID: A5087580329
Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight
2020 · Terence C. S. Ho, Alex H. Y. Chan, et al. · Journal of Medicinal Chemistry · 797
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Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity
2022 · Alex H. Y. Chan, Imam Fathoni, et al. · RSC Medicinal Chemistry · 30
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Prodrugs of pyrophosphates and bisphosphonates: disguising phosphorus oxyanions
2022 · Emma S. Rudge, Alex H. Y. Chan, et al. · RSC Medicinal Chemistry · 27
ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma
2024 · Yuting Lu, Jana Travnickova, et al. · Cell Reports · 21
Inhibition of Thiamine Diphosphate-Dependent Enzymes by Triazole-Based Thiamine Analogues
2023 · Alex H. Y. Chan, Terence C. S. Ho, et al. · ACS Medicinal Chemistry Letters · 20
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Design of thiamine analogues for inhibition of thiamine diphosphate (ThDP)-dependent enzymes: Systematic investigation through Scaffold-Hopping and C2-Functionalisation
2023 · Alex H.Y. Chan, Terence C.S. Ho, et al. · Bioorganic Chemistry · 17
Furan-based inhibitors of pyruvate dehydrogenase: SAR study, biochemical evaluation and computational analysis
2023 · Alex H. Y. Chan, Terence C. S. Ho, et al. · Organic & Biomolecular Chemistry · 15
Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase
2023 · Alex H.Y. Chan, Terence C.S. Ho, et al. · Bioorganic & Medicinal Chemistry Letters · 10
Synthesis of pyrrothiamine, a novel thiamine analogue, and evaluation of derivatives as potent and selective inhibitors of pyruvate dehydrogenase
2022 · Alex H. Y. Chan, Terence C. S. Ho, et al. · Organic & Biomolecular Chemistry · 10
Evaluation of ketoclomazone and its analogues as inhibitors of 1-deoxy- d -xylulose 5-phosphate synthases and other thiamine diphosphate (ThDP)-dependent enzymes
2024 · Alex H. Y. Chan, Terence C. S. Ho, et al. · RSC Medicinal Chemistry · 9
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Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes
2023 · Alex H. Y. Chan, Terence C. S. Ho, et al. · Organic & Biomolecular Chemistry · 8
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Identification and characterization of thiamine analogs with antiplasmodial activity
2024 · Imam Fathoni, Terence C. S. Ho, et al. · Antimicrobial Agents and Chemotherapy · 6
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ALDH1A3-acetaldehyde metabolism potentiates transcriptional heterogeneity in melanoma
2024 · Yuting Lu, Jana Travnickova, et al. · Cell Reports · 5
Triazole-Based Thiamine Analogues as Inhibitors of Thiamine Pyrophosphate-Dependent Enzymes: 1,3-Dicarboxylate for Metal Binding
2024 · Terence C. S. Ho, Alex H. Y. Chan, et al. · ACS Omega · 3
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Discovery and SAR Studies of Viral Processivity Factor 8 (PF-8) Inhibitors as Anti-Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Agents
2026 · Života Selaković, Marie-Sophie Schulze, et al. · Journal of Medicinal Chemistry
Plasmodium thiamine pyrophosphokinase is essential for sporozoite formation and activation of an antiplasmodial thiamine analogue
2026 · Imam Fathoni, Ümit Y. Kina, et al. · Proceedings of the National Academy of Sciences
Analogues of N3-Pyridyl Thiamine: Biochemical Evaluation, Computational Analysis, and Anti-plasmodial Activity
2026 · Terence C S Ho, Alex H Y Chan, et al. · ChemRxiv
Analogues of N3-Pyridyl Thiamine: Biochemical Evaluation, Computational Analysis, and Anti-plasmodial Activity
2026 · Terence C S Ho, Alex H Y Chan, et al. · ChemRxiv
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Correction: Thiamine analogues as inhibitors of pyruvate dehydrogenase and discovery of a thiamine analogue with non-thiamine related antiplasmodial activity
2022 · Alex H. Y. Chan, Imam Fathoni, et al. · RSC Medicinal Chemistry
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Works count: 19
Citation count: 978
H-index: 9
I10-index: 9
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