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Akifumi Kushiyama

AMP-activated Protein Kinase Activation Increases Phosphorylation of Glycogen Synthase Kinase 3β and Thereby Reduces cAMP-responsive Element Transcriptional Activity and Phosphoenolpyruvate Carboxykinase C Gene Expression in the Liver
2008 · Nanao Horike, Hideyuki Sakoda, et al. · Journal of Biological Chemistry · 199
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Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis
2016 · Akifumi Kushiyama, Yusuke Nakatsu, et al. · Mediators of Inflammation · 189
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Oxidative stress induces insulin resistance by activating the nuclear factor-?B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase
2004 · T. Ogihara, T. Asano, et al. · Diabetologia · 153
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Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and Atherosclerosis Development
2011 · Akifumi Kushiyama, Hirofumi Okubo, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 131
Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus
2015 · Shirong Qiang, Yusuke Nakatsu, et al. · Diabetology & Metabolic Syndrome · 116
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Lactobacillus caseistrain Shirota protects against nonalcoholic steatohepatitis development in a rodent model
2013 · Hirofumi Okubo, Hideyuki Sakoda, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 111
Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages
2018 · Hiroki Yamazaki, Akifumi Kushiyama, et al. · Mediators of Inflammation · 92
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Linking uric acid metabolism to diabetic complications
2014 · Akifumi Kushiyama, Kentaro Tanaka, et al. · World Journal of Diabetes · 92
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The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice
2017 · Yusuke Nakatsu, Hiroki Kokubo, et al. · International Journal of Molecular Sciences · 91
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The xanthine oxidase inhibitor febuxostat suppresses development of nonalcoholic steatohepatitis in a rodent model
2015 · Yusuke Nakatsu, Yasuyuki Seno, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 91
Role of Phosphatidylinositol 3-Kinase Activation on Insulin Action and Its Alteration in Diabetic Conditions
2007 · Tomoichiro Asano, Midori Fujishiro, et al. · Biological and Pharmaceutical Bulletin · 89
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Adipocyte-macrophage interaction may mediate LPS-induced low-grade inflammation: Potential link with metabolic complications
2011 · Hideo Nakarai, Akiko Yamashita, et al. · Innate Immunity · 81
Gut Microbiota as a Therapeutic Target for Metabolic Disorders
2017 · Hirofumi Okubo, Yusuke Nakatsu, et al. · Current Medicinal Chemistry · 79
Peptidyl-prolyl Cis/Trans Isomerase NIMA-interacting 1 Associates with Insulin Receptor Substrate-1 and Enhances Insulin Actions and Adipogenesis
2011 · Yusuke Nakatsu, Hideyuki Sakoda, et al. · Journal of Biological Chemistry · 69
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Resistin-like Molecule β Activates MAPKs, Suppresses Insulin Signaling in Hepatocytes, and Induces Diabetes, Hyperlipidemia, and Fatty Liver in Transgenic Mice on a High Fat Diet
2005 · Akifumi Kushiyama, Nobuhiro Shojima, et al. · Journal of Biological Chemistry · 66
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DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation
2015 · Takanori Shinjo, Yusuke Nakatsu, et al. · American Journal of Physiology-Endocrinology and Metabolism · 60
Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice
2019 · Masa-Ki Inoue, Yasuka Matsunaga, et al. · Diabetology & Metabolic Syndrome · 59
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Role of hepatic AMPK activation in glucose metabolism and dexamethasone-induced regulation of AMPK expression
2006 · Amelia Y.I. Viana, Hideyuki Sakoda, et al. · Diabetes Research and Clinical Practice · 53
Physiological and Pathogenic Roles of Prolyl Isomerase Pin1 in Metabolic Regulations via Multiple Signal Transduction Pathway Modulations
2016 · Yusuke Nakatsu, Yasuka Matsunaga, et al. · International Journal of Molecular Sciences · 50
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Protection from diet-induced obesity and insulin resistance in mice lacking CCL19-CCR7 signaling
2015 · Tomomi Sano, Misaki Iwashita, et al. · Obesity · 49
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Carnosic Acid and Carnosol Activate AMPK, Suppress Expressions of Gluconeogenic and Lipogenic Genes, and Inhibit Proliferation of HepG2 Cells
2021 · Shun Hasei, Takeshi Yamamotoya, et al. · International Journal of Molecular Sciences · 47
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Serum concentrations of resistin-like molecules β and γ are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow
2005 · N. Shojima, T. Ogihara, et al. · Diabetologia · 46
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Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice
2019 · Yu Mizuno, Takeshi Yamamotoya, et al. · International Journal of Molecular Sciences · 44
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Prolyl isomerase Pin1 in metabolic reprogramming of cancer cells
2019 · Yusuke Nakatsu, Takeshi Yamamotoya, et al. · Cancer Letters · 43
Prolyl Isomerase Pin1 Negatively Regulates AMP-activated Protein Kinase (AMPK) by Associating with the CBS Domain in the γ Subunit
2015 · Yusuke Nakatsu, Misaki Iwashita, et al. · Journal of Biological Chemistry · 43
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Works count: 138
Citation count: 3,593
H-index: 36
I10-index: 80
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