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Koen Vandyck
Observed names:
K VANDYCK,
K. Vandyck,
Koen VanDyck
Institution:
Galapagos (Belgium)
Observed institutions:
Merck & Co., Inc., Rahway, NJ, USA (United States),
Uppsala University Hospital,
Janssen (Belgium),
University of Antwerp,
Vanderbilt University,
Ghent University,
SGS (Belgium),
Galapagos (Belgium)
show all 8
ORCID:
0000-0002-0923-8301
Observed ORCID:
0000-0002-0923-8301
OpenAlex ID:
A5087896942
Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: Results from two randomized, double-blind, placebo-controlled studies with single oral doses
2005
·
G HERMAN
, C STEVENS
, et al.
·
Clinical Pharmacology & Therapeutics
·
517
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir
2023
·
Dirk Jochmans
, Cheng Liu
, et al.
·
mBio
·
197
PDF
Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary Human Hepatocytes Infected with Hepatitis B Virus
2017
·
Jan Martin Berke
, Pascale Dehertogh
, et al.
·
Antimicrobial Agents and Chemotherapy
·
164
PDF
Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection
2021
·
Koen Vandyck
, Jerome Deval
·
Current Opinion in Virology
·
132
PDF
Novel Potent Capsid Assembly Modulators Regulate Multiple Steps of the Hepatitis B Virus Life Cycle
2018
·
Thomas Lahlali
, Jan Martin Berke
, et al.
·
Antimicrobial Agents and Chemotherapy
·
104
PDF
Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379
2020
·
Jan Martin Berke
, Pascale Dehertogh
, et al.
·
Antimicrobial Agents and Chemotherapy
·
78
Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)
2020
·
Xuan G. Luong
, Sarah K. Stevens
, et al.
·
PLoS ONE
·
76
Some new C2-symmetric bicyclo[2.2.1]heptadiene ligands: synthesis and catalytic activity in rhodium(I)-catalyzed asymmetric 1,4- and 1,2-additions
2007
·
Timothy Noël
, Koen Vandyck
, et al.
·
Tetrahedron
·
65
Rhodium-Catalyzed Asymmetric Conjugate Additions of Boronic Acids to Enones Using DIPHONANE: A Novel Chiral Bisphosphine Ligand
2005
·
Koen Vandyck
, Bavo Matthys
, et al.
·
Organic Letters
·
62
Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase
2009
·
Koen Vandyck
, Maxwell D. Cummings
, et al.
·
Journal of Medicinal Chemistry
·
61
1,5-Benzodiazepine inhibitors of HCV NS5B polymerase
2009
·
David McGowan
, Origène Nyanguile
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
60
2′-Deoxy-2′-spirocyclopropylcytidine Revisited: A New and Selective Inhibitor of the Hepatitis C Virus NS5B Polymerase
2010
·
Tim H. M. Jonckers
, Tse-I Lin
, et al.
·
Journal of Medicinal Chemistry
·
56
Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development
2021
·
Cheng Liu
, Sandro Boland
, et al.
·
Antiviral Research
·
55
Synthesis and Evaluation of N -Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV)
2018
·
Koen Vandyck
, Geert Rombouts
, et al.
·
Journal of Medicinal Chemistry
·
55
Nucleotide Prodrugs of 2′-Deoxy-2′-spirooxetane Ribonucleosides as Novel Inhibitors of the HCV NS5B Polymerase
2013
·
Tim H. M. Jonckers
, Koen Vandyck
, et al.
·
Journal of Medicinal Chemistry
·
48
Determination of the Absolute Configuration of Three as-Hydrindacene Compounds by Vibrational Circular Dichroism
2005
·
T. Kuppens
, K. Vandyck
, et al.
·
The Journal of Organic Chemistry
·
48
1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus
2010
·
Origène Nyanguile
, Benoit Devogelaere
, et al.
·
Journal of Virology
·
41
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model
2021
·
Koen Vandyck
, Rana Abdelnabi
, et al.
·
Biochemical and Biophysical Research Communications
·
40
PDF
d-Isomannide in synthesis: asymmetric Diels–Alder reactions with novel homochiral bis-imine Cu2+-catalysts
2002
·
Gert De Coster
, Koen Vandyck
, et al.
·
Tetrahedron Asymmetry
·
39
Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH
2024
·
Koen Vandyck
, David C. McGowan
, et al.
·
Journal of Medicinal Chemistry
·
38
Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry
2020
·
Zachary A. Gurard-Levin
, Cheng Liu
, et al.
·
Antiviral Research
·
35
PDF
A DFT conformational analysis and VCD study on methyl tetrahydrofuran-2-carboxylate
2006
·
Tom Kuppens
, Koen Vandyck
, et al.
·
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
·
35
Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library
2017
·
Ilane Hernandez-Morales
, Peggy Geluykens
, et al.
·
Antiviral Research
·
28
Chiral imidates as a new class of nitrogen-based chiral ligands: synthesis and catalytic activity in asymmetric aziridinations and diethylzinc additions
2009
·
Timothy Noël
, Koen Vandyck
, et al.
·
Tetrahedron
·
26
Practical Synthesis of (2′R)-2′-Deoxy-2′-C-methyluridine by Highly Diastereoselective Homogeneous Hydrogenation
2010
·
Sébastien Lemaire
, Ioannis Houpis
, et al.
·
The Journal of Organic Chemistry
·
21
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Works count:
44
Citation count:
2,149
H-index:
24
I10-index:
28
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