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Ruichao Shen

Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced β cell dysfunction in isolated pancreatic islets
2006 · Chen-Yu Zhang, Laura E. Parton, et al. · Cell Metabolism · 333
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Synthesis of Enamides Related to the Salicylate Antitumor Macrolides Using Copper-Mediated Vinylic Substitution
2000 · Ruichao Shen, John A. Porco · Organic Letters · 228
Lobatamide C: Total Synthesis, Stereochemical Assignment, Preparation of Simplified Analogues, and V-ATPase Inhibition Studies
2003 · Ruichao Shen, Cheng Ting Lin, et al. · Journal of the American Chemical Society · 162
Copper-Mediated Synthesis of N -Acyl Vinylogous Carbamic Acids and Derivatives: Synthesis of the Antibiotic CJ-15,801
2003 · Chong Han, Ruichao Shen, et al. · Organic Letters · 131
Total Synthesis and Stereochemical Assignment of the Salicylate Antitumor Macrolide Lobatamide C
2002 · Ruichao Shen, Cheng Ting Lin, et al. · Journal of the American Chemical Society · 104
Optimization of a Natural Product-Based Class of γ-Secretase Modulators
2012 · Jed L. Hubbs, Nathan O. Fuller, et al. · Journal of Medicinal Chemistry · 46
Synthesis and V-ATPase Inhibition of Simplified Lobatamide Analogues
2002 · Ruichao Shen, Cheng Ting Lin, et al. · Organic Letters · 40
Synthesis of Photoactivatable Acyclic Analogues of the Lobatamides
2005 · Ruichao Shen, Takao Inoue, et al. · The Journal of Organic Chemistry · 37
The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo
2024 · Michael H. J. Rhodin, Archie C. Reyes, et al. · Nature Communications · 36
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Modulation of Gamma-Secretase for the Treatment of Alzheimer's Disease
2012 · Barbara Tate, Timothy D. McKee, et al. · International Journal of Alzheimer s Disease · 26
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Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models
2013 · Robyn M Loureiro, Jo Ann Dumin, et al. · Alzheimer s Research & Therapy · 24
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Studies of the Stereochemistry of [2+2]-Photocycloaddition Reactions of 2-Cyclohexenones with Olefins
2007 · Ruichao Shen, E. J. Corey · Organic Letters · 19
Characterization of EDP-305, a Highly Potent and Selective Farnesoid X Receptor Agonist, for the Treatment of Non-alcoholic Steatohepatitis
2019 · Mary Chau, Yang Li, et al. · International Journal of Gastroenterology · 16
The identification of novel 5′-amino gemcitabine analogs as potent RRM1 inhibitors
2014 · Marc A. Labroli, Michael P. Dwyer, et al. · Bioorganic & Medicinal Chemistry · 11
Minimization of drug–drug interaction risk and candidate selection in a natural product-based class of gamma-secretase modulators
2015 · Jed L. Hubbs, Nathan O. Fuller, et al. · Bioorganic & Medicinal Chemistry Letters · 9
Molecular Basis for Antiviral Action of EDP‐235: A Potent and Selective SARS‐CoV‐2 3CLpro Inhibitor for the Treatment of Covid 19
2022 · Anand Balakrishnan, Archie Reyes, et al. · The FASEB Journal · 8
Optimization of a Kilogram-Scale Synthesis of a Potent Cycloartenol Triterpenoid-Derived γ-Secretase Modulator
2014 · Nathan O. Fuller, Jed L. Hubbs, et al. · Organic Process Research & Development · 8
Syntheses of 5′-amino-2′,5′-dideoxy-2′,2′-difluorocytidine derivatives as novel anticancer nucleoside analogs
2013 · Marc A. Labroli, Michael P. Dwyer, et al. · Tetrahedron Letters · 8
Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment
2026 · Jun Yang, Ruichao Shen, et al. · Nature Chemical Biology · 5
Multikilogram-Scale Production of Cycloartenol Triterpenoid Glycosides as Synthetic Intermediates for a γ-Secretase Modulator
2014 · Ruichao Shen, Nathan O. Fuller, et al. · Organic Process Research & Development · 4
O1‐11‐01: Satori gamma‐secretase modulators are efficacious in wild‐type rodents following either acute or steady‐state dosing
2012 · Robyn Loureiro, Timothy McKee, et al. · Alzheimer s & Dementia · 1
Copper‐Mediated Synthesis of N‐Acyl Vinylogous Carbamic Acids and Derivatives: Synthesis of the Antibiotic CJ‐15,801.
2004 · Chong Han, Ruichao Shen, et al. · ChemInform · 1
CCDC 1817711: Experimental Crystal Structure Determination
2018 · Fuller, Nathan O., Hubbs, Jed L., et al. · The Cambridge Structural Database
CCDC 1817710: Experimental Crystal Structure Determination
2018 · Fuller, Nathan O., Hubbs, Jed L., et al. · The Cambridge Structural Database
Discovery and Development of the Natural Product Derivative SPI-1865 as a Gamma Secretase Modulator for Alzheimer’s Disease: Part I
2016 · Jed L. Hubbs, Nathan O. Fuller, et al. · ACS symposium series
Works count: 34
Citation count: 1,257
H-index: 13
I10-index: 14
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