Author

Tatsuo Akaki

Institution: Japan Tobacco (Japan)

Observed institutions: Japan Tobacco (United States), Japan Tobacco (Japan), Kindai University, The University of Osaka

ORCID: 0000-0002-8341-641X

Observed ORCID: 0000-0002-8341-641X

OpenAlex ID: A5089059548

Generation and Cycloaddition of Polymer-Supported Azomethine Ylide via a 1,2-Silatropic Shift of α-Silylimines: Traceless Synthesis of Pyrrolidine Derivatives

2002 · Mitsuo Komatsu, Hirofumi Okada, et al. · Organic Letters · 43

Generation and cycloaddition of polymer-supported azomethine ylide by utilizing the characteristics of silicon: a facile route to pyrrolidines and pyrroles from α-silylimines bound to resin

2003 · Hirofumi Okada, Tatsuo Akaki, et al. · Tetrahedron · 21

Fragment-based lead discovery to identify novel inhibitors that target the ATP binding site of pyruvate dehydrogenase kinases

2021 · Tatsuo Akaki, Yuki Bessho, et al. · Bioorganic & Medicinal Chemistry · 18

Antiviral Activity and Resistance Profile of the Novel HIV-1 Non-Catalytic Site Integrase Inhibitor JTP-0157602

2022 · Yoshitsugu Ohata, Mitsunori Tomonaga, et al. · Journal of Virology · 14

The discovery of 3,3-dimethyl-1,2,3,4-tetrahydroquinoxaline-1-carboxamides as AMPD2 inhibitors with a novel mechanism of action

2022 · Yuki Kitao, Tadataka Saito, et al. · Bioorganic & Medicinal Chemistry Letters · 10

Structure-based drug design of novel and highly potent pyruvate dehydrogenase kinase inhibitors

2021 · Yuki Bessho, Tatsuo Akaki, et al. · Bioorganic & Medicinal Chemistry · 9

Fragment-Based Discovery of Novel VE-PTP Inhibitors Using Orthogonal Biophysical Techniques

2023 · Wataru Asano, Kenji Yamanaka, et al. · Biochemistry · 6

Fragment Molecular Orbital Based Affinity Prediction toward Pyruvate Dehydrogenase Kinases: Insights into the Charge Transfer in Hydrogen Bond Networks

2023 · Tatsuo Akaki, Shinya Nakamura, et al. · Chemical and Pharmaceutical Bulletin · 5

System truncation accelerates binding affinity calculations with the fragment molecular orbital method: A benchmark study

2022 · Shinya Nakamura, Tatsuo Akaki, et al. · Journal of Computational Chemistry · 5

Identification of AMPD2 allosteric inhibitors with novel mechanism of action by fragment merging approach

2026 · Kenji Yamanaka, Toru Uhara, et al. · SLAS DISCOVERY

The Discovery of 3,3-Dimethyl-1,2, 3,4-Tetrahydroquinoxaline-1-Carboxamide As AMPD2 Inhibitors With a Novel Mechanism of Action

2022 · Yuki Kitao, Tadataka Saito, et al. · SSRN Electronic Journal

Works count: 11

Citation count: 131

H-index: 6

I10-index: 5