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Yukun Guan

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy
2020 · Mengze Lv, Meixia Chen, et al. · Cell Research · 1,040
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Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses
2018 · Chenguang Wang, Yukun Guan, et al. · Immunity · 869
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Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity
2011 · Huihui Chen, Hui Sun, et al. · Cell · 375
Mn2+ Directly Activates cGAS and Structural Analysis Suggests Mn2+ Induces a Noncanonical Catalytic Synthesis of 2′3′-cGAMP
2020 · Zhen Zhao, Zhixing Ma, et al. · Cell Reports · 332
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Manganese salts function as potent adjuvants
2021 · Rui Zhang, Chenguang Wang, et al. · Cellular and Molecular Immunology · 318
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MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner
2017 · Run Fang, Qifei Jiang, et al. · PLoS Pathogens · 211
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Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
2021 · Run Fang, Qifei Jiang, et al. · Immunity · 169
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Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models
2023 · Dechun Feng, Xiaogang Xiang, et al. · Journal of Clinical Investigation · 93
Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure
2022 · Jing Ma, Adrien Guillot, et al. · Journal of Clinical Investigation · 90
MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression
2023 · Yaojie Fu, Bryan Mackowiak, et al. · Gut · 86
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Ethanol and its Nonoxidative Metabolites Promote Acute Liver Injury by Inducing ER Stress, Adipocyte Death, and Lipolysis
2022 · Seol Hee Park, Wonhyo Seo, et al. · Cellular and Molecular Gastroenterology and Hepatology · 79
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IL-8+ neutrophils drive inexorable inflammation in severe alcohol-associated hepatitis
2024 · Yukun Guan, Brandon Peiffer, et al. · Journal of Clinical Investigation · 59
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E-Selectin-Dependent Inflammation and Lipolysis in Adipose Tissue Exacerbate Steatosis-to-NASH Progression via S100A8/9
2021 · Robim M. Rodrigues, Yong He, et al. · Cellular and Molecular Gastroenterology and Hepatology · 51
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Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-κB pathways with novel theanine derivatives
2014 · Guoying Zhang, Xinshan Ye, et al. · Oncotarget · 47
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Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners
2021 · Yeni Ait Ahmed, Yaojie Fu, et al. · Cellular and Molecular Immunology · 46
Inflammation in Alcohol-Associated Hepatitis: Pathogenesis and Therapeutic Targets
2024 · Dechun Feng, Seonghwan Hwang, et al. · Cellular and Molecular Gastroenterology and Hepatology · 44
NLRP6 self-assembles into a linear molecular platform following LPS binding and ATP stimulation
2020 · Fangwei Leng, Hang Yin, et al. · Scientific Reports · 38
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Acute depletion of BRG1 reveals its primary function as an activator of transcription
2024 · Gang Ren, Wai Lim Ku, et al. · Nature Communications · 30
Characterisation of macrophages in healthy and diseased livers in mice: identification of necrotic lesion-associated macrophages
2025 · Dechun Feng, Yukun Guan, et al. · eGastroenterology · 27
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Infiltrating macrophages replace Kupffer cells and play diverse roles in severe alcohol-associated hepatitis
2025 · Yang Wang, Yukun Guan, et al. · Cellular and Molecular Immunology · 23
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New therapeutic target for alcohol-associated hepatitis (AH): AH-associated IL-8+ neutrophils
2024 · Yukun Guan, Dechun Feng, et al. · eGastroenterology · 21
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Targeting adipose tissue to tackle NASH: SPARCL1 as an emerging player
2021 · Robim M. Rodrigues, Yukun Guan, et al. · Journal of Clinical Investigation · 19
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Hepatic CYP2B10 is highly induced by binge ethanol and contributes to acute‐on‐chronic alcohol‐induced liver injury
2022 · Bryan Mackowiak, Mingjiang Xu, et al. · Alcoholism Clinical and Experimental Research · 14
DMAP-based flexible polymer networks formed via Heck coupling as efficient heterogeneous organocatalysts
2016 · Wei Xu, Wu Xia, et al. · Reactive and Functional Polymers · 12
Adipocyte death promotes hepatic infiltration of S100A8+ macrophages and steatotic liver disease progression in mice
2025 · Yukun Guan, Yeonsoo Kim, et al. · Journal of Clinical Investigation · 11
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Works count: 48
Citation count: 4,152
H-index: 21
I10-index: 26
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