Author

Amit M. Shah

Observed names: A SHAH, Amit Shah

Observed institutions: University of Minnesota, University of Leeds, Genomatica (United States), University of New Mexico, Lund University, Aarhus University, Yale University

ORCID: 0000-0002-6623-8228

Observed ORCID: 0000-0002-6623-8228

OpenAlex ID: A5090226373

Comparison of Naturally Occurring Vitamin K-Dependent Proteins: Correlation of Amino Acid Sequences and Membrane Binding Properties Suggests a Membrane Contact Site

1997 · John F. McDonald, Amit M. Shah, et al. · Biochemistry · 102

Visualization of enzyme-catalyzed reactions using pH indicators: rapid screening of hydrolase libraries and estimation of the enantioselectivity

1999 · Francisco Morı́s-Varas, Amit Shah, et al. · Bioorganic & Medicinal Chemistry · 79

Vitamin K-dependent proteins

2000 · Gary L. Nelsestuen, Amit M. Shah, et al. · Vitamins and hormones · 68

Y265H Mutator Mutant of DNA Polymerase β

2001 · Amit M. Shah, Shu-Xia Li, et al. · Journal of Biological Chemistry · 58

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

2009 · Frank Ruebsam, Douglas E. Murphy, et al. · Bioorganic & Medicinal Chemistry Letters · 44

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7′-substitution of benzothiadiazine

2008 · Yuefen Zhou, Stephen E. Webber, et al. · Bioorganic & Medicinal Chemistry Letters · 42

Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation

2004 · Thomas Doundoulakis, Alan X. Xiang, et al. · Bioorganic & Medicinal Chemistry Letters · 41

Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase

2007 · Ricardo Lira, Alan X. Xiang, et al. · Bioorganic & Medicinal Chemistry Letters · 40

Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

2008 · Frank Ruebsam, Stephen E. Webber, et al. · Bioorganic & Medicinal Chemistry Letters · 37

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments

2008 · Lian-Sheng Li, Yuefen Zhou, et al. · Bioorganic & Medicinal Chemistry Letters · 35

Variants of DNA Polymerase β Extend Mispaired DNA Due to Increased Affinity for Nucleotide Substrate

2003 · Amit M. Shah, Mausumi Maitra, et al. · Biochemistry · 32

Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase

2008 · Sun Hee Kim, Martin T. Tran, et al. · Bioorganic & Medicinal Chemistry Letters · 31

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents

2008 · Yuefen Zhou, Lian-Sheng Li, et al. · Bioorganic & Medicinal Chemistry Letters · 30

5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

2008 · Frank Ruebsam, Chinh V. Tran, et al. · Bioorganic & Medicinal Chemistry Letters · 29

Enhancing the Activity of Protein C by Mutagenesis To Improve the Membrane-Binding Site: Studies Related to Proline-10

1997 · Lei Shen, Amit M. Shah, et al. · Biochemistry · 28

4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase

2008 · David A. Ellis, Julie K. Blazel, et al. · Bioorganic & Medicinal Chemistry Letters · 27

A DNA Polymerase β Mutator Mutant with Reduced Nucleotide Discrimination and Increased Protein Stability,

2001 · Amit M. Shah, Danyal A. Conn, et al. · Biochemistry · 25

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents

2008 · Peter S. Dragovich, Julie K. Blazel, et al. · Bioorganic & Medicinal Chemistry Letters · 23

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties

2008 · Maria V. Sergeeva, Yuefen Zhou, et al. · Bioorganic & Medicinal Chemistry Letters · 22

Manipulation of the membrane binding site of vitamin K-dependent proteins: Enhanced biological function of human factor VII

1998 · Amit M. Shah, Walter Kisiel, et al. · Proceedings of the National Academy of Sciences · 22

Enhancement of Human Protein C Function by Site-directed Mutagenesis of the γ-Carboxyglutamic Acid Domain

1998 · Lei Shen, Amit M. Shah, et al. · Journal of Biological Chemistry · 20

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Auslander-Reiten theory in quasi-abelian and Krull-Schmidt categories

2019 · Amit Shah · Journal of Pure and Applied Algebra · 17

Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

2008 · Frank Ruebsam, Zhongxiang Sun, et al. · Bioorganic & Medicinal Chemistry Letters · 17

5,5′- and 6,6′-Dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

2009 · David A. Ellis, Julie K. Blazel, et al. · Bioorganic & Medicinal Chemistry Letters · 15

Ionic Properties of Membrane Association by Vitamin K-Dependent Proteins: The Case for Univalency

1997 · John F. McDonald, Thomas C. Evans,, et al. · Biochemistry · 10

Works count: 31

Citation count: 914

H-index: 20

I10-index: 25