Author

Deepani W. Poramba‐Liyanage

Observed names: D.W.L. Poramba Liyanage, Deepani W. Poramba-Liyanage, Deepani W Poramba-Liyanage, Deepani W. Poramba-Liyanage, Deepani W.L. Poramba Liyanage, Deepani W.L. Poramba-Liyanage, Poramba Liyanage, D. W. L., Poramba Liyanage, D.W.L., Poramba Liyanage, Deepani, Poramba Liyanage, Deepani W. L., Poramba-Liyanage, D.W., Poramba-Liyanage, Deepani W.

Institutions: Utrecht University, The Netherlands Cancer Institute

Observed institutions: Radboud University Nijmegen, Utrecht University, The Netherlands Cancer Institute, Radboud Institute for Molecular Life Sciences

ORCID: 0000-0003-3717-4787

Observed ORCID: 0000-0003-3717-4787

OpenAlex ID: A5091799602

Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration

2022 · Frances C. Bach, Deepani W. Poramba-Liyanage, et al. · Frontiers in Cell and Developmental Biology · 61

Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism

2018 · Tibor van Welsem, Tessy Korthout, et al. · Nucleic Acids Research · 33

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Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1

2016 · Hanneke Vlaming, Thom M Molenaar, et al. · eLife · 31

NuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells

2018 · Susan L. Kloet, Ino D. Karemaker, et al. · Nature Communications · 27

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Recommendations for intervertebral disc notochordal cell investigation: From isolation to characterization

2023 · Rebecca J. Williams, Lisanne T. Laagland, et al. · JOR Spine · 26

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Decoding the chromatin proteome of a single genomic locus by DNA sequencing

2018 · Tessy Korthout, Deepani W. Poramba-Liyanage, et al. · PLoS Biology · 19

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Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes

2020 · Deepani W. Poramba-Liyanage, Tessy Korthout, et al. · Genome Research · 12

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Isolation and tracing of matrix-producing notochordal and chondrocyte cells using ACAN-2A-mScarlet reporter human iPSC lines

2024 · Xiaole Tong, Deepani W. Poramba-Liyanage, et al. · Science Advances · 8

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Hyperosmolar expansion medium improves nucleus pulposus cell phenotype

2022 · Lisanne T. Laagland, Frances C. Bach, et al. · JOR Spine · 8

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Disc-Derived Induced Pluripotent Stem Cells and Environmental Cues for Nucleus Pulposus Regeneration

2025 · Lisanne T. Laagland, Deepani W.L. Poramba Liyanage, et al. · Tissue Engineering Part A · 5

Epi-ID: Systematic and Direct Screening for Chromatin Regulators in Yeast by Barcode-ChIP-Seq

2019 · Deepani W. Poramba-Liyanage, Tessy Korthout, et al. · Methods in molecular biology · 3

A bioactive hydrogel harnessing the regenerative potential of notochordal cells serves as instructive cell carrier for nucleus pulposus repair

2025 · Lisanne T. Laagland, Elias Salzer, et al. · Biomaterials · 2

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Single-cell multi-omics defines H3K27me3 remodelling in intervertebral disc degeneration with implications for regenerative intervention

2026 · Deepani W. Poramba-Liyanage, Xiaole Tong, et al. · Bone Research

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CRISPR activation reveals SOX5/6/9 as key transcriptional regulators directing iPSC-derived cells toward a notochordal lineage

2026 · Xiaole Tong, Marieke Visscher, et al. · Stem Cell Reports

Single-cell multi-omics defines H3K27me3 remodelling in intervertebral disc degeneration with implications for regenerative intervention

2026 · Poramba-Liyanage, Deepani W., Tong, Xiaole, et al. · White Rose Research Online (University of Leeds, The University of Sheffield, University of York)

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Single-cell multi-omics defines H3K27me3 remodelling in intervertebral disc degeneration with implications for regenerative intervention

2026 · Poramba-Liyanage, Deepani W., Tong, Xiaole, et al. · Zenodo (CERN European Organization for Nuclear Research)

Advancing stem cell-based technologies for intervertebral disc regeneration: Exploring biology-driven cues to improve iPSCs differentiation toward notochordal-like cells

2025 · Tong, Xiaole, Locomotion - Surgery (CA), et al. · Utrecht University Repository (Utrecht University)

Breaking the Vicious Circle of Nucleus Pulposus Degeneration: Exploring Advanced Treatment Options for Lower Back Pain

2025 · Laagland, Lisanne Theresia, Locomotion - Surgery (CA), et al. · Utrecht University Repository (Utrecht University)

CRISPR Activation Interrogation of iPSC-Based Notochordal Lineage Reveals the Functional Significance of the SOX Genes in Disc Regeneration

2025 · Xiaole Tong, Marieke Visscher, et al. · SSRN Electronic Journal

Prediction of Damage in SLE Using Unbiased Analysis of Large Datasets

2020 · Eric F. Morand, D.W.L. Poramba Liyanage, et al. · Arthritis & Rheumatism

Author response: Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1