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Pierre Springuel

Observed name: P. Springuel
ORCID: 0009-0008-3295-3953
Observed ORCID: 0009-0008-3295-3953
OpenAlex ID: A5091918453
A quality-by-design approach to improve process understanding and optimise the production and quality of CAR-T cells in automated stirred-tank bioreactors
2024 · Tiffany Hood, Fern Slingsby, et al. · Frontiers in Immunology · 18
Establishing a scalable perfusion strategy for the manufacture of CAR ‐T cells in stirred‐tank bioreactors using a quality‐by‐design approach
2025 · Tiffany Hood, Pierre Springuel, et al. · Bioengineering & Translational Medicine · 9
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Optimising and adapting perfusion feeds in serum-free medium to intensify CAR-T cell expansion in stirred-tank bioreactors
2025 · Pierre Springuel, Tiffany Hood, et al. · Frontiers in Bioengineering and Biotechnology · 7
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Merosin deficient congenital muscular dystrophy type 1A: An international workshop on the road to therapy 15-17 November 2019, Maastricht, the Netherlands
2021 · Hubert J.M. Smeets, Bram Verbrugge, et al. · Neuromuscular Disorders · 7
Impact of Serum/Xeno‐Free Medium and Cytokine Supplementation on CAR‐T Cell Therapy Manufacturing in Stirred Tank Bioreactors
2025 · Pedro Silva Couto, Dale J. Stibbs, et al. · Biotechnology Journal · 6
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Impact of physical and chemical parameters on spinoculation for chimeric antigen receptor T cell manufacturing using a quality-by-design approach
2026 · Pedro Silva Couto, Dale J. Stibbs, et al. · Molecular Therapy Advances · 2
Perfusion-powered production of over 100 CAR-T doses in a 2-litre stirred-tank bioreactor with automated product harvest, wash and concentration
2025 · P. Springuel, F. Slingsby, et al. · Cytotherapy · 2
Sergio Sismondo (2018) Ghost-Managed Medicine: Big Pharma’s invisible hands. Manchester: Mattering Press. 231 pages. eISBN: 97809955277782
2019 · Jessica Mesman, Dawn Goodwin, et al. · Science & Technology Studies · 2
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Optimising Car-t Cell Expansion Via Mathematical Modeling of Two Distinct Perfusion Bioreactors
2025 · J. Egan, N. Marí-Buyé, et al. · Cytotherapy · 1
Process Development for Scalable Allogeneic Car-t Manufacturing in Stirred-tank Bioreactors: Perfusion Optimisation, Multi-litre Scale-up and Automated Harvesting
2024 · P. Springuel, T. Hood, et al. · Cytotherapy · 1
Assessment of a Novel All-in-one Bioreactor for Intensified Autologous Car-t Cell Manufacturing
2026 · P. Springuel, J. Silva, et al. · Cytotherapy
Ai-powered Prediction of Car-t Cell Expansion in Real-time Using Online Data of Dissolved Oxygen and Gas Flow Rates
2026 · J. Egan, P. Springuel, et al. · Cytotherapy
Perfusion-enabled Car-t Manufacturing in Stirred-tank Bioreactors Achieving 100+ Doses Per Batch
2026 · R. Ladi, P. Springuel, et al. · Cytotherapy
Scalable CAR-T production in a 2-litre perfusion stirred-tank bioreactor with automated harvesting and scale-down model characterisation
2026 · Pierre Springuel, Pedro Silva Couto, et al. · Frontiers in Bioengineering and Biotechnology
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Evaluation of Physical and Molecular Parameters on Transduction in Chimeric Antigen Receptor T-cell (car-t) Manufacturing
2025 · S. McLean, P.S. Couto, et al. · Cytotherapy
Development of a Serum-free Production Workflow for Car T-cell Therapies in Stirred Tank Bioreactors
2025 · P. Silva Couto, P. Springuel, et al. · Cytotherapy
Maximizing CAR-T cell yields: scalable solutions with perfusion and stirred-tank bioreactors
2025 · Julia Hengst, Qasim Rafiq, et al. · Cell and Gene Therapy Insights
Scalable Manufacturing of Car-t Cells Using a Non-viral Approach and a Transposon-transposase System
2024 · P. Silva Couto, D. Stibbs, et al. · Cytotherapy
Expanding T-cells to High Cell Concentrations in a Microfluidic Perfused Device
2024 · J. Aranda-Hernandez, O. Derevianko, et al. · Cytotherapy
Process Development and Manufacturing: OPTIMISING PERFUSION PARAMETERS USING QUALITY BY DESIGN FOR THE INTENSIFIED PRODUCTION OF CAR T CELLS IN A SINGLE-USE AUTOMATED STIRRED-TANK BIOREACTOR
2023 · P. Springuel, T. Hood, et al. · Cytotherapy
Process Development and Manufacturing: IMPACT OF XENO-FREE AND SERUM FREE MEDIUM FORMULATIONS FOR CAR-T CELL MANUFACTURING
2023 · P. Silva Couto, P. Springuel, et al. · Cytotherapy
Book review: Sergio Sismondo (2018) Ghost-Managed Medicine: Big Pharma’s invisible hands. Manchester: Mattering Press.
2019 · Jessica Mesman, Dawn Goodwin, et al. · Lancaster EPrints (Lancaster University)
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Works count: 22
Citation count: 55
H-index: 5
I10-index: 1
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