Author

Jon H. Come

Observed names: Come, Jon H., J H Come, J. COME, J. Come, J. H. COME, Jon Come, Jon Come (20983001)

Institution: Tango Therapeutics (United States)

Observed institutions: Broad Institute, Scripps Research Institute, National Institutes of Health, Pennsylvania State University, Harvard University, Tango Therapeutics (United States), National Institute of Allergy and Infectious Diseases, Janssen Research & Development (United States), Rocky Mountain Laboratories, Vertex Pharmaceuticals (United States), Massachusetts Institute of Technology

ORCID: 0009-0006-8463-4247

Observed ORCID: 0009-0006-8463-4247

OpenAlex ID: A5094260107

Cell-free formation of protease-resistant prion protein

1994 · David A. Kocisko, Jon H. Come, et al. · Nature · 898

A kinetic model for amyloid formation in the prion diseases: importance of seeding.

1993 · J H Come, P E Fraser, et al. · Proceedings of the National Academy of Sciences · 402

A Three-Hybrid Approach to Scanning the Proteome for Targets of Small Molecule Kinase Inhibitors

2004 · Frank Becker, Krishna Murthi, et al. · Chemistry & Biology · 139

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Small-Molecule Immunostimulants. Synthesis and Activity of 7,8-Disubstituted Guanosines and Structurally Related Compounds

1994 · Allen B. Reitz, Michael G. Goodman, et al. · Journal of Medicinal Chemistry · 55

Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS)

2018 · Jon H. Come, Philip N. Collier, et al. · Journal of Medicinal Chemistry · 51

Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3-Kinase γ

2015 · Philip N. Collier, David Messersmith, et al. · Journal of Medicinal Chemistry · 35

Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones

2007 · Upul K. Bandarage, Tiansheng Wang, et al. · Bioorganic & Medicinal Chemistry Letters · 34

Novel thiol-based TACE inhibitors: Rational design, synthesis, and SAR of thiol-containing aryl sulfonamides

2007 · B. Govinda Rao, Upul K. Bandarage, et al. · Bioorganic & Medicinal Chemistry Letters · 33

Mechanistic and preparative studies of the intramolecular photocyclization of methylated 2-(4-pentenyl)tropones

1989 · Ken S. Feldman, Jon H. Come, et al. · The Journal of Organic Chemistry · 33

ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors

2018 · Upul K. Bandarage, Jingrong Cao, et al. · Bioorganic & Medicinal Chemistry Letters · 32

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2

2009 · Mark W. Ledeboer, Albert C. Pierce, et al. · Bioorganic & Medicinal Chemistry Letters · 28

Predisposition of prion protein homozygotes to Creutzfeldt-Jakob disease can be explained by a nucleation-dependent polymerization mechanism

1994 · Jon H. Come, Peter T. Lansbury · Journal of the American Chemical Society · 28

4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: Potent and selective p70S6 kinase inhibitors

2009 · Upul Bandarage, Brian Hare, et al. · Bioorganic & Medicinal Chemistry Letters · 26

Synthesis of eight-membered carbocycles via intramolecular [6.pi. + 2.pi.] photocycloaddition of alkenyl tropones

1986 · Ken S. Feldman, Jon H. Come, et al. · Journal of the American Chemical Society · 26

Discovery of Novel, Orally Bioavailable Pyrimidine Ether-Based Inhibitors of ELOVL1

2021 · Michael J. Boyd, Philip N. Collier, et al. · Journal of Medicinal Chemistry · 19

Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1

2021 · Jon H. Come, Timothy J. Senter, et al. · Journal of Medicinal Chemistry · 17

Discovery of a Novel Series of Potent and Selective Alkynylthiazole-Derived PI3Kγ Inhibitors

2020 · Upul K. Bandarage, Alex M. Aronov, et al. · ACS Medicinal Chemistry Letters · 16

Large-scale combination screens reveal small-molecule sensitization of antibiotic-resistant gram-negative ESKAPE pathogens

2025 · Megan W. Tse, Meilin Zhu, et al. · Proceedings of the National Academy of Sciences · 15

ROCK inhibitors 4: Structure-activity relationship studies of 7-azaindole-based rho kinase (ROCK) inhibitors

2020 · Upul K. Bandarage, John Court, et al. · Bioorganic & Medicinal Chemistry Letters · 12

Convenient synthesis of N-(4-(2-aminopyridin-4-yl)thiazol-2-yl)-2-phenylacetamides

2006 · Upul K. Bandarage, Jon H. Come, et al. · Tetrahedron Letters · 9

LIG1 Is a Synthetic Lethal Target in BRCA1 Mutant Cancers

2025 · Lauren Catherine M. Martires, Leanne G. Ahronian, et al. · Molecular Cancer Therapeutics · 8

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A convenient synthesis of 7-allyl-8-substituted guanosines

1991 · J. Come, L. Burr, et al. · Tetrahedron Letters · 8

Guanosine Derivatives as Immunostimulants. Discovery of Loxoribine

1994 · Robert Chen, Michael G. Goodman, et al. · Nucleosides and Nucleotides · 5

792 TNG917: a potent and orally active inhibitor of euchromatic histone lysine methyltransferases (EHMT1/2) for the treatment of immune-cold tumors

2024 · Alvin Lu, Brian Haines, et al. · Journal for ImmunoTherapy of Cancer · 1

HPTN 069/ACTG A5305: phase II study of maraviroc-containing regimens for HIV PrEP in US women; Postive impact of a randomized controlled trial of the Uthando Lwethu ("Our Love") intervention on rates of couples HIV testing in rural South Africa

2016 · Adam J. Ericsen, Michael Lauck, et al. · 1

Works count: 77

Citation count: 1,935

H-index: 16

I10-index: 19